Research Projects Ongoing
Title: Nebraska Bioterrorism Plan
Funding agency: HRSA
Project period: 09/01/04-08/31/05
Principal Investigator: Steven H. Hinrichs,
Tony Sambol
Purpose: Establish enhanced capability for
response to biological events of state and national concern.
Title: FY 04 Homeland Security Grant
Program (SHSP)
Funding agency: NEMA
Project period: 12/01/04-5/31/06
Principal Investigator: Steven H. Hinrichs
Purpose: Contribute to state-wide emergency
preparedness through leveraging the resources of the University of Nebraska.
Title: National Electronic Disease
Surveillance System
Funding agency: DHHS
Project Period: 2/1/05-12/31/06
Principal Investigator: Steven H. Hinrichs
Purpose: Provide contract services for
administration of state NEDSS program.
Title: FY 2005 Department of Homeland
Security - LETPP
Funding agency: NEMA
Project Period: 4/1/2005-3/31/07
Principal Investigator: Steven H. Hinrichs
Purpose: Protect critical infrastructure
for use in response to emergencies.
Title: Department of Homeland Security SHSG
Funding agency: NEMA
Project Period: 4/1/05-3/31/07
Principal Investigator: Steven H. Hinrichs
Purpose: Improve communications within UNS
system.
Title: New Therapeutic Strategies for
Antibiotic Resistant Select Agents
Funding agency: DoD
Project Period: 5/15/05-11/14/06
Principal Investigator: Steven H. Hinrichs
Purpose: Develop novel strategy for
treatment of antibiotic resistant organism.
Title: Bioterrorism Laboratory Services
Agreement, CT, Focus Area D
Funding agency: HRSA
Project Period: 9/1/05-9/30/06
Principal Investigator: Steven H. Hinrichs
Purpose: Develop level II chemical terrorism laboratory capability.
Title: Bioterrorism Laboratory Services
Agreement, BT Focus Area C
Funding agency: HRSA
Project Period: 9/1/05-9/30/06
Principal Investigator: Steven H. Hinrichs
Purpose: Improve preparedness for
Bioterrorism-related events in Nebraska.
Title: Proteomic Approach to Identification
of Proteins for Evaluation in New Diagnostic Tests
Funding agency: AFIP
Project Period: 8/15/05-2/15/06
Principal Investigator: Steven H. Hinrichs
Purpose: Explore protein-based methods for
identification of select agents.
Title: Neurotoxin Mitigation
Funding agency: US Army
Project Period: 10/21/05-11/21/06
Principal Investigator: Steven H. Hinrichs
Purpose: Develop novel approaches for
treatment of exposure to organophosphate poisons.
Title: Neurotoxin Mitigation
Funding agency: US Army
Project Period: 10/21-05-11/21/06
Principal Investigator: Oksana Loughridge
Secondary Investigator: Steven H. Hinrichs
Purpose: Identify markers of exposure to
organophosphate poisons.
Title: Nebraska Bioterrorism Plan, Focus
Area D, Laboratory Capacity, Chemical Agents
Funding agency’s name: State of Nebraska CDC
Cooperative Agreement
Total project period: 08/31/03-08/31/05 –
renewed through 9/30/06
Principal Investigator: Steven H. Hinrichs,
M.D.
Purpose: This project extends the
capability of NPHL to detect chemical agents.
Title: Bioterrorism Laboratory Services
Agreement
Funding agency’s name: State of Nebraska CDC
Cooperative Agreement
Total project period: 07/01/02-06/30/05
Principal Investigator: Steven H. Hinrichs,
M.D.
Purpose: This grant provides basic
operational support for the NPHL Bioterrorism program.
Title: “Gene and protein therapy for
poisoning by organophosporus agents”
Funding agency’s name: U.S. Army
Total project period: 09/01/01 – 08/31/05
Principal Investigator: Oksana Lockridge,
Ph.D.
Co-Investigator: Steven H. Hinrichs, M.D.
Purpose: The goal of this project is to
determine the feasibility of replacing AChE activity using mutant (knockout)
mice
Title: Nebraska Center for Rural
Biosecurity
Funding agency:
CDC
Project period: 07/04 - 06/05
Funding Amount: $931,901
Principal Investigator: Steven H. Hinrichs
Purpose: Establish a coordinated program
for electronic registration of health care workforce and data exchange
between laboratories.
Title: Nebraska High Performance Wireless
Research and Education Network
Funding agency: NRI
Project period: 07/2004-07/2006
Funding amount: $345,357
Principal Investigator: Hesham Ali
Co-Investigator: Steven H. Hinrichs
Purpose: Develop new approaches for
monitoring of quality and safety in the medical setting.
Title: Mid-America Alliance
Funding agency’s name: State of Nebraska
Total project period: 08/30/04-08/31/05
renewed through 9/30/06
Principal Investigator: Steven H. Hinrichs,
M.D.
Purpose: The goal of this project is to
establish a framework for mutual aid between states in the Midwest to
address public health events that do not initiate a governor declared
emergency.
Title: Critical Reagents Program
Funding agency’s name: US Army Space and
Missile Defense Command
Total project period: 08/25/04-08/24/05
Principal Investigator: Steven H. Hinrichs,
M.D.
Purpose: The purpose of this project is to
develop new diagnostic approaches and reagents for the identification of
biological weapons of concern to the US military.
Title: Nebraska Center for Rural
Biosecurity
Funding agency’s name: DHHS/CDC Cooperative
Agreement
Total project period: 08/01/04-07/31/05
Principal Investigator: Steven H. Hinrichs,
M.D.
Purpose: Establish a coordinated program
for electronic registration of health care workforce and data exchange
between laboratories.
Research Projects Recently Completed
Title: Nonclassical functions of
acetylcholinesterase
Funding agency’s name: NIH
Total project period: 04/01/00-03/31/04
Principal Investigator: Oskana Lockridge,
Ph.D.
Co-Investigator: Steven H.
Hinrichs, M.D.
Purpose: This grant established the
importance of butyl cholinesterase as a second enzyme capable of maintaining
life function in a knockout animal.
Title: Molecular characterization and
pathogenesis of Francisella tularensis
Funding agency’s name: UNL/UNMC Vice
Chancellors for Research
Total project period: 04/01/00-03/31/04
Co-Principal Investigator: Mike Meagher,
Ph.D. / Steven H. Hinrichs, M.D.
Co-Investigator: Peter C.
Iwen, Ph.D.
Purpose: As a Select
Agent Registered facility, this work involves the molecular characterization
of F. tularensis for the isolation of pathogenesis genes and for the
development of vaccine candidates.
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Fey, Paul D, Wickert RS, Rupp ME,
Safranek TJ, Hinrichs SH. Prevalence of Non-0157:H7 Shiga
toxin-producing Escherichia coli in diarrheal stool samples from
Nebraska. Emerging Infectious Diseases 6:530-33, Sept-Oct 2000.
Fey PD, Safranek TJ, Rupp ME, Dunne EF,
Ribot E, Iwen PC, Bradford PA, Angulo FJ, Hinrichs SH.
Ceftriaxone-resistant Salmonella infection acquired by a child from
cattle. The New England Journal of Medicine 342 (17):1242-49, 2000.
Henry T, Iwen PC, Hinrichs SH.
Identification of Aspergillus species using internal transcribed
spacer regions 1 and 2. Journal of Clinical Microbiology,
38(4):1510-1515, April 2000.
Olsen, RJ, Hinrichs SH.
Phosphorylation of the EWS IQ domain regulates transcriptional activity
of the EWS/ATF1 and EWS/FL11 fusion proteins. Oncogene 20(14):1756-64
March, 2001.
Mazlo J, Stanfield RL, Wilson IA,
Hinrichs SH, Stezowski JJ. Preliminary X-ray diffraction studies of
the transcriptional inhibitory antibody Fab41.4. Acta Crystallogr D
Biol Crystallogr 57, 462-464, 2001.
Olsen, RJ, Hinrichs SH.
Phosphorylation of the EWS IQ domain regulates transcriptional activity
of the EWS/ATF1 and EWS/FL11 fusion proteins. Oncogene 20(14): 1756-64
March, 2001
Carattoli A, Tosini F, Giles WP, Rupp
ME, Hinrichs SH, Angulo FJ, Barrett TJ, Fey PD. Characterization
of plasmids carrying CMY-2 from expanded-spectrum
cephalosporin-resistant Salmonella strains isolated in the United
States between 1996 and 1998. Antimicrob Agents Chemother
46(5):1269-1272, 2002..
Iwen PC, Hinrichs SH, Rupp ME.
Utilization of the internal transcribed spacer regions as molecular
targets to detect and identify human fungal pathogens. Medical
Mycology, 40(1):87-109, 2002.
Olsen RJ, Tarantolo SR, Hinichs SH.
Molecular approaches to sarcoma therapy. Sarcoma 6(1):27-42, March,
2002.
Liang MH, Geisbert T, Yao Y, Hinrichs
SH, Giam CZ. Human T-lymphotropic virus type 1 oncoprotein tax
promotes S-phase entry but blocks mitosis. J Virol. Apr; (8):4022-33,
2002.
Duysen EG, Stribley JA, Fry DL,
Hinrichs SH, Lockridge O. Rescue of acetylcholinesterase knockout
mouse by feeding a liquid diet; phenotype of the adult
acetylcholinesterase deficient mouse. Brain Res Dev Brain Res,
137(1):43-54 July, 2002.
Fey PD, Said-Salim B, Rupp ME,
Hinrichs SH, Boxrud DJ, Davis CC, Kreiswirth BN, Schlievert PM.
Comparative molecular analysis of community-or hospital-acquired
Methicillin-resistant Staphylococcus aureus. Antimicrob Agents &
Chemo, 47(1):196-202, January, 2003.
Stickle DF, McKenzie DA, Landmark JD,
Pirruccello SJ, Post GA, Iwen PC, Thompson RD, Hinrichs SH.
Effects of sterilizing gamma irradiation on bloodspot newborn screening
tests and on whole blood cyclosporine and tacrolimus measurements. Am J
Clin Pathol,119(2):292- Feb, 2003.
Tarkin IS, Henry TJ, Fey PI, Iwen PC,
Hinrichs SH. PCR rapidly detects methicillin resistant
staphylococci periprosthetic infection. Clin Orthop. (414):89-94, Sep,
2003.
Stickle DF, Birch NC, Pirruccello SJ,
Hinrichs SH. Urine specimen integrity monitoring using the Vitros
creatinine assay. Clin Chem Acta. 334(1-2):253-5, Aug, 2003.
Bastola DR, Out HH, Doukas S, Sayood K,
Hinrichs SH, Iwen P. Utilization of the relative complexity
measure to construct a phylogenetic tree for fungi. Mycol Res ,
107(0):1-10, 2003.
Olsen RJ, Mazlo J, Koepsell SA,
McKeithan TW, Hinrichs SH. Minimal structural elements of
inhibitory anti-ATF1/CREB single-chain antibody fragment (scFv41.4).
Hybrid Hybridomics, 22(2):65-77, April, 2003.
Birch NC, Stickle DF, Young A, Medina P,
Hinrichs SH. Evaluation of urine specimen integrity in a public
health STD screening program. Am J Clin Pathol, 119(4):516-21, April,
2003.
Mohamed AM, Bastola DR, Morlock GP,
Cooksey RC, Hinrichs SH. Temperature-mediated heteroduplex
analysis for detection of pncA mutations associated with prrazinamide
resistance and differentiation between Mycobacterium tuberculosis and
Mycobacterium bovis by denaturing high-performance liquid
chromatography. J Clin Microbiol, 42(3): 1016-23, March, 2004.
Iwen PC, Freifeld AG, Bruening TA,
Hinrichs SH. Use of a Panfungal PCR assay for detection of fungal
pathogens in a commercial blood culture system. J Clin Microbiol
42(5): 2292-3, May 2204.
Samrakandi MM, Zhang C, Zhang M,
Nietfeldt J, Kim J, Iwen PC, Olson ME, Fey PD, Duhamel GE, Hinrichs
SH, Cirillo JD, Benson AK. Genome diversity among regional
populations of Francisella tularensis subspecies tularensis and
Francisella tularensis subspecies holarctica isolated from the US. FEMS
Microbiol Lett 237(1):9-17, Aug 1, 2004.
Koepsell S, Bastola D, Hinrichs SH,
Griep MA. Thermally denaturing high-performance liquid chromatography
and analysis of primase activity. Anal Biochem 332(2): 330-6, Sep 15,
2004.
Mohamed AM, Iwen PC, Tarantolo S,
Hinrichs SH. Mycobacterium nebraskense sp. nov., a novel slowly
growing scotochromogenic species. Int J Syst Evol Microbiol 54 (Pt 6):
2057-60, Nov 2004
Mohamed AM, Kuyper DJ, Iwen PC, Ali HH,
Bastola DR, Hinrichs SH. Computational approach for the
identification of Mycobacterium species using the internal
transcribed spacer-1 region. J Clin. Microbiol. Aug 2005 3811-3817.
Koepsell, SA,
Hanson, S, Hinrichs SH, Griep, MA. Fluorometric Assay
for Bacterial Primases. Anal Biochem. 2005 339: 353-355.
Chandio SH, Bastola DR, Iwen PC, Hinrichs SH. Identification of
Pathogenic Fungi Using Computational and
Molecular Biological Approaches. The 2005 IEEE International Conference
on Electro Information Technology, May 22-25, Lincoln, NE
Olsen RJ, Lydiatt
WM, Koepsell SA, Lydiatt D, Johansson SL, Naumann S, Bridge JA, Neff JR,
Hinrichs SH, Tarantolo SR. C-erb-B2(HER2/neu) Expression in
Synovial Sarcoma of the Head and Neck. Head&Neck 27 pp. 883-892, 2005
Schweitzer BK, Kramer WL, Sambol AR,
Meza JL, Hinrichs SH, Iwen PC. Geographic Factors Contributing
to a High Seroprevalence of Wet Nile Virus-Specific Antibodies in Humans
Following an Epidemic. Clin Vaccine Immunol. 2006 Mar; 13(3):314-8.
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