Pathology and Microbiology

Thomas R. Jerrells, PhD

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ACADEMIC DEGREES:
BS Medical Microbiology, Univ Arizona, 1972
MS Bacteriology and Public Health, Washington State Univ 1974
PhD Bacteriology and Public Health, Washington State Univ 1976

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Contact Name: Thomas R. Jerrells, PhD.
Phone Number: 402-346-8800 ext 3361
e-mail address: tjerrell@unmc.edu

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• GRANT SUPPORT (last 3 years):

T32 AA07557; National Institute on Alcohol Abuse and Alcoholism: "Research Training on the Effects of Alcohol on Immunity"; Program Director, March 1994-February1999
F31 AA05365: "Effect of Ethanol Consumption on Mucosal Defense Mechanisms";Mentor for Predoctoral Fellow, Don Sibley
R13 AA11306; National Institute on Alcohol Abuse and Alcoholism: "Alcohol and Immunology Research Interest Group Meeting"; Organizer, April 1, 1996-March 31,1997
R13 AA11544; National Institute on Alcohol Abuse and Alcoholism: "Alcohol and Immunology Research Interest Group Meeting"; Organizer, April 1, 1997-March 31,1998
RO1 AA07731; National Institute on Alcohol Abuse and Alcoholism: "Mechanisms of Ethanol-Induced Impairments in Immunity"; Principal Investigator, September 1998-September 2003
RO1 AA12450; National Institute on Alcohol Abuse and Alcoholism: "The Role Immune Responses in Alcoholic Liver Diseases"; Principal Investigator, April 1999-March 2003.
T32 AA07582; National Institute on Alcohol Abuse and Alcoholism: "Biochemistry and Immunology of Alcoholic Liver Disease"; Training Director (Principal Investigator), July 2000-June 2005

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• PUBLICATIONS (last 3-5 years):

Jerrells TR, Weinberg J. Influence of ethanol consumption on immune competence of adult animals exposed to ethanol in utero. Alcoholism: Clinical and Experimental Research 1998;22:391-400.

Jerrells TR, Sibley DA, Slukvin II, Mitchell KA. Effects of ethanol consumption on mucosal and systemic T-cell-dependent immune responses to pathogenic microorganisms. Alcoholism: Clinical and Experimental Research 1998;22(5 suppl):212S-215S.

Padgett EL, Sibley DA, Jerrells TR. Effect of adrenalectomy on ethanol-associated changes in lymphocyte cell numbers and subpopulations in thymus, spleen, and gut-associated lymphoid tissue. International Journal of Immunopharmacology. 22:285-298, 2000.

Sibley DA, Jerrells TR. Alcohol consumption is associated with depletion of the GALT and altered resistance to oral infections with Salmonella typhimurium in C57BL/6 mice. Journal of Infectious Diseases. 182:482-489, 2000.

Slukvin II, Boor PJ, Jerrells TR. Initiation of alcoholic fatty liver and hepatic inflammation by a specific recall immune response in alcohol-consuming C57Bl/6 mice. Clinical and Experimental Immunology. 2000.

Sibley DA, Jerrells TR. Alcohol consumption is associated with alterations inmacrophage responses to interferon-gamma and infection by Salmonella typhimurium. Journal of Infectious Diseases. 2000

Jerrells TR. Role of activated CD8⁺ T cells in the initiation and continuation of hepatic damage. Alcohol 2001;27:47-52.

Slukvin II, Boor P, and Jerrells TR. Initiation of alcoholic fatty liver and hepatic inflammation with a specific recall immune response in alcohol-consuming C57Bl/6 mice. Clin Exp Immunol. 2001; 225:123-133.

Clemens DL, Forman A, Jerrells TR, Sorrell MF, Tuma DJ. Relationship between acetaldehyde levels and cell survival in ethanol-metabolizing hepatoma cells. Hepatology. 2002, 35:1196-1204.

Jerrells TR, Mitchell K, Pavlik J, Jerrells J, Hoerman D. Influence of Ethanol Consumption on Experimental Viral Hepatitis. Alcohol Clin Exp Res. 2002;26:1734-1746.

Jerrells TR. Association of alcohol consumption and exaggerated immunopathologic effects in the liver induced by infectious organism. Front Biosci. 2002;7:1487-93.

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Judith F. Aronson, 1989-91; Present position: Assistant Professor, Department of Pathology, University of Texas Medical Branch, Galveston

K. Kannan, 1990-92; Present position: Research Associate, Louisiana State University Medical Center, Shreveport

Thomas E. Kruger, 1992-93; Present position: Postdoctoral Fellow, Department of Ophthalmology, Louisiana State University Medical Center, Shreveport

Mashkoor Ahmad Choudhry, 1993-94; Present position: Research Fellow, Burn & Shock Trauma Institute, Loyola University Medical Center, Maywood, Illinois

Igor I. Slukvin, 1994-96; Present position: Senior Research Associate, Wisconsin Regional Primate Center, University of Wisconsin, Madison

GRADUATE STUDENTS:

Past:
Bennie A. Palmer	Master of Science, 1985
Carol J. Hickman	Doctor of Philosophy, 1988
Peigin Geng	Master of Science, 1991
Rana Domiati-Saad	Doctoral Candidate, University of Texas Medical Center, Dallas
Don A. Sibley	Doctor of Philosophy, 1996
Current:
Mindy Purdue

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Research is focused on immune responses to model antigens and bacteria and viruses that infect the liver. Emphasis is on the immunopathologic effects of the immune responses to hepatotropic viruses and bacteria. Studies on the responses of hepatocytes to infection, activated lymphocytes, and cytokines are done with the use of experimental animal models as well as in vitro assays. Studies are also being done to determine the immunoregulatory aspects of immune responses to pathogenic miroorganisms in the gastrointestinal tract.

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• SPECIALIZED LABORATORY/CLINICAL RESEARCH RESOURCES:

Laboratory resources include photomicroscopy set up with digital camera attachment and high quality printer. As well as a flow cytometry center with an analytical flow cytometer (Facs Scan) and a high-speed sorter (Facs Vantage with turbo sort). Thermocyclers and other equipment for molecular biological assays including phosphoimagers.

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