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Otolaryngology - Head and Neck Surgery

Donald A. Leopold, M.D.

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ACADEMIC DEGREES:

B.S.E. University of Michigan (Engineering) 1969
M.D. Ohio State University 1973
M.S.B. Johns Hopkins University (Masters of Science in Business) 1999
1973-1974 Internship, Surgery, St. Luke’s Hospital Center, New York
1974-1978 Resident in Otolaryngology, University Hospitals, Iowa City, Iowa

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Contact Name: Donald A. Leopold, M.D.
Phone Number: 402-559-8007
e-mail address: dleopold@unmc.edu

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National Institutes of Health (NIH) - Institute of Child Health and Disease.
Program Grant #HD24448-11.   “Pathogenesis of Rett Syndrome.
1st Year Budget = $746,641.
Investigations into the suitability of the human olfactory neuron as a model for the neurons in patients with Rett Syndrome.

American Rhinologic Society
 “Human Nasal Mucosal Sensitivity is decreased in Older People”
 $8,000 grant  ·  July 2003-June 2004

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Beck, L.A., Stellato, C., Beall, L.D., Schall, T.J., Leopold, D.A., Bickel, C.A., Baroody, F., Bochner, B.S., and Schleimer, R.P. "Allergens, IgE, Mediators, Inflammatory Mechanisms: Detection of the Chemokine Rantes and Endothelial Adhesion Molecules in Nasal Polyps." Journal of Allergy and Clinical Immunology, 98(4): 766-80. 1996.

Tebo, S.A., Leopold, D.A., Long, D.M., Zinreich, S.J., and Kennedy, D.W. "An Optical 3D Digitizer for Frameless Stereotactic Surgery." IEEE Computer Graphics and Applications, 16(1): 55-64. Jan. 1996.

Melhem, E.R., Oliverio, P.J., Benson, M.L., Leopold, D.A., and Zinreich, S.J. "Optimal CT Evaluation for Functional Endoscopic Sinus Surgery." American Journal Neuroradiology, 17(1): 181-8. Jan. 1996.

Leopold, D.A. " A History of Rhinology in North America." Otolaryngology - Head and Neck Surgery, 115(4):283-297. Oct. 1996.

Leopold, D.A. "Management of Rhinosinusitis." Hospital Medicine, 33(2S): 40-44. Feb. 1997.

Manoukian, P.D., Wyatt, J.R., Leopold, D.A., and Bass, E.B. "Recent Trends in Utilization of Procedures in Otolaryngology - Head and Neck Surgery." Laryngoscope, 107(4): 472-7. April 1997.

Menache, M.G., Hanna, L.M., Gross, E.A., Lou, S.R., Zinreich, S.J., Leopold, D.A., Jarabek, A.M., and Miller, F.J. "Upper Respiratory Tract Surface Areas and Volumes of Laboratory Animals and Humans: Considerations for Dosimetry Models." Journal of Toxicology & Environmental Health, 11;50(5): 475-506. June 1997.

Nguyen, Q.A. and Leopold, D.A. "Current Concepts in the Surgical Management of Chronic Frontal Sinusitis." Otolaryngologic Clinics of North America, 30(3): 355-70. June 1997.

Lenz, F.A., Gracely, R.H., Zirh, T.A., Leopold, D.A., Rowland, L.H., and Dougherty, P.M. "Human Thalamic Nucleus Mediating Taste and Multiple Other Sensations Related to Ingestive Behavior." Journal of Neurophysiology, 77: 3406-9. June 1997.

Leopold, D.A., Ferguson, B.J. and Piccirillo, J.F. "Outcomes Assessment." Otolaryngology - Head and Neck Surgery, 117(3 Pt 2): S58-68. Sept. 1997.

Hong, S.C., Leopold, D.A., Zinreich, S.J., Oliverio, P.J., Benson, M.L., Mellits, D., and Quaskey, S.A. "Relation Between CT Scan Findings and Human Sense of Smell." Otolaryngology - Head and Neck Surgery, 118(2): 183-6. Feb. 1998.

Cullen, M.M. and Leopold, D.A. "Intranasal Frontal Sinusotomy" in "Current Opinion." Otolaryngology - Head and Neck Surgery, 6(1): 31-40. Feb. 1998.

Hornung, D.E., Smith, D.J., Kurtz, D.B., White, T., and Leopold, D.A. "Effect of Nasal Dilators on Olfaction: I Nasal Structure and Sniffing Strategies." Submitted to Rhinology, Feb. 1998.

Smith, D.J., Hornung, D.E., Kurtz, D.B., White, T., and Leopold, D.A. "Effect of Nasal Dilators on Olfaction: II Threshold, Intensity and Identification. Submitted to Rhinology, Feb. 1998.

Perry, J.D., Girkin, C.A., Miller, N.R., and Leopold, D.A. "Carcinoid Tumor of the Orbit Managed by Transnasal Endoscopic Biopsy and Decompression." Submitted to Archives of Ophthalmology, 1998.

Hornung, D.E. and Leopold, D.A. "The Relationship Between Uninasal Anatomy and Uninasal Olfactory Ability." Archives of Otolaryngology - Head and Neck Surgery, 125(1): 53-8. Jan. 1999.

Cullen, M.M. and Leopold, D.A. "Disorders of Smell and Taste." Medical Clinics of North America. 83(1): 57-74. Jan. 1999.

Rhyoo, C., Sanders, S.P., Leopold, D.A., and Proud, D. "Sinus Mucosal Interleukin-8 Gene Expression in Chronic Rhinosinusitis." Journal of Allergy and Clinical Immunology, 103(3 Pt 1): 395-400. March 1999.

Leopold, D.A., Hong, S.C., Quaskey, S.A., Enger, C., Oliverio, P.J., Benson, M.L., and Zinreich, S.J. "Nasal & Sinus Symptoms and their CT Scan Correlations." Submitted 1999.

Wang, X.J., Moylan. B., Leopold, D.A., Rubenstein, R.C., Proud, D., Togias, A., Zeitlin, P., and Cutting, G.R. "An Increased Frequency of Mutations in Chronic Rhinosinusitis." Submitted 1999.

Loehrl, T.A. and Leopold, D.A. "Sphenoethmoidal Mucocele Presenting with Bilateral Visual Compromise. " Submitted to Annals of Otology, Rhinology, Laryngology. 1999.

Leopold, D.A., Cai. X., Naidu, S., Yablanski, M.B., Loehrl, T.A., and Ronnett, G.V. "Olfactory Epithelial Morphology in Children With and Without Rett Syndrome." Submitted 1999.

Loehrl, T.A., Schwob, J.E. and Leopold, D.A. "Long Term Follow-up on Patients With Surgically Treated Phantosmia." Submitted 1999.

Marcucci, C., Leopold, D.A., Cullen, M., Zinreich, S.J., and Simon, B.A. "Dynamic Assessment of Paranasal Sinus Ventilation Using Xenon-Enhanced Computed Tomography." Submitted Nov. 1999.

Leopold, D.A., Zinreich, S.J., Simon, B.A., Cullen, M.M., and Marcucci, C. "Xenon-Enhanced Computed Tomography Quantifies Normal Maxillary Sinus Ventilation." Otolaryngology - Head and Neck Surgery, 122: 422-424. March 2000.

Leopold, D.A., Hummel, T., Schwob, J.E., Kobal,G., Hong, S.C., and Knecht, M. "Anterior Distribution of Human Olfactory Epithelium." Laryngoscope, 110(3 Pt 1):417-21. March 2000.

Wang, XinJing, Moylan, Birgitta, Leopold, Donald, Kim, Jean, Rubenstein, Ronald, Togias, Alkis, Proud, David, Zeitlin, Pamela, and Cutting, Garry. "Mutation in the Gene Responsible for Cystic Fibrosis and Predisposition to Chronic Rhinosinusitis in the General Population." The Journal of the American Medical Association, Vol. 284, No. 14, 1814-1819. October 11, 2000.

Snyder, Mary C., Leopold, Donald, Chiu, Brian C., VonEssen, Susanna G., Liebentritt, Nicholas.  “Olfactory Ability of Farmers.”  Submitted to Chest.  December 2000.

Gagnon, M., Gigantelli, J., Arthur, J., Leopold, D.  “Endoscopic Transethmoidal Decompression of a Thrombosed Orbital Venous Malformation.”  Submitted to Archives of Opthalmology.  December 2000.

Hornung, D.E., Smith, D.J., Kurtz, D.B., White, T. Leopold, D.A.  “Effect of Nasal Dilators on Nasal Structures, Sniffing Strategies and Olfactory Ability.”  Rhinology, Vol. 39, No. 2, 84-7.  June 2001.

Say, P., Leopold, D.A., Cochran, G., Greiner, T.  “Removal of the Inferior Third of the Superior Turbinate is Not Associated with a Significant Decrease in Human Olfactory Ability.”  Chemical Senses, Vol. 26, No. 8, 339, 1113.  October 2001.

Gigantelli, J.W., Gagnon, M.R., Arthur, J.S., Leopold, D.A.  “Endoscopic Tranethmoidal
Decompression of a Thrombosed Orbital Venous Malformation.”  Ear, Nose & Throat Journal, Vol. 81, No. 5, 346-51.  May 2002.

Leopold, D.A.  “Distortion of Olfactory Perception:  Diagnosis and Treatment.”  Chemical Senses, Vol. 27, No. 7, pg. 611-615.  September 2002.

Ronnett, G.V., Leopold, D.A., Cai, X., Hoffbuhr, K.C., Moses, L., Hoffman, E.P., Naidu, S.B. “Olfactory Biopsies Demonstrate a Defect in Neuronal Development in Rett’s Syndrome.” Annals of Neurology, Vol 54:2. August 2003.

Holbrook, E.H., Leopold, D.A.  “Anosmia:  Diagnosis and Management.”  Current Opinion in
Otolaryngology & Head and Neck Surgery, 2003; 11(1): 54-60.  January 2003.

Vent, J., Bartels, S., Haynatzki, G., Gentry-Nielsen, M.J., Leopold, D.A., and Hallworth, R.  “The Impact of Ethanol and Tobacco Smoke on Intranasal Epithelium in the Rat.”  American
Journal of Rhinology, Vol. 17: 4. July-August 2003.

Snyder, Mary C., Leopold, Donald, Chiu, Brian C., VonEssen, Susanna G., Liebentritt, Nicholas.   “The Relationship Between Agricultural Environments and Olfactory Dysfunction.” Journal of Agricultural Safety and Health. Volume 9(3):211-219. 2003

Frasnelli, J., Landis, BN, Heilmann, S., Hauswald, B., Hüttenbrink, KB., Lacroix, JS., Leopold, DA., Hummel, T. “Clinical Presentation of qualitative olfactory dysfunction.” Eur Auch Otorhinolaryngoly. November 2003.

Benninger, M.S., Hadley, J.A., Osguthorpe, J.D., Marple, B.F., Leopold, D.A., Derebery, M.J., Hannley, M. “Techniques of Intranasal Steroid Use.” Otolaryngology – Head and Neck Surgery. Volume 130(1):5-24. January 2004.

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  • PREVIOUS GRADUATE STUDENTS/POST-DOCTORAL FELLOWS (present location):
Quoc Nguyen 1996-97 Irvine, California
Michelle Cullen 1997-98 Atlanta, Georgia
Stephanie Joe 1998 Houston, Texas
Todd Loehrl 1998-99 Milwaukee, Wisconsin
Sande Bartels Irwin 2001-02 Portland, Oregon
Eric Holbrook 2002-03 Boston, Mass
Bozena Wrobel 2003-04  

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Touch Carbon Dioxide and Temperature Stimulation of the Nasal Mucosa, Development of Technology and Assessment of Techniques, with Mapping.  In collaboration with the School of Engineering, University of Nebraska, Lincoln

Sense of Smell in Patients Undergoing Obesity Reduction Surgery

Are Sinus CT scans clinically helpful?  Correlation between CT and symptoms study.

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Access to ENT clinic and clinical patients

Engineering laboratory facilities through the University of Nebraska, Lincoln, College of Engineering