Masson P, Nachon F, Bartels CF, Froment MT, Ribes F, Matthews C,
Lockridge O (2003) High activity of human
butyrylcholinesterase at low pH in the presence of excess
butyrylthiocholine. Eur J Biochem 270:315-324.
Li B,
Duysen EG, Volpicelli LA, Levey AI, Lockridge O (2003)
Regulation of muscarinic acetylcholine receptor function in
acetylcholinesterase knockout mice. Pharmacology,
Biochemistry, and Behavior 74: 977-986
Volpicelli-Daley
LA, Duysen EG, Lockridge O, Levey AI (2003) Altered
hippocampal muscarinic receptors in acetylcholinesterase-deficient
mice. Ann Neurol 53:788-96.
Bernard V, Brana
C, Liste I, Lockridge O, Bloch B (2003) Dramatic depletion
of cell surface m2 muscarinic receptor due to limited
delivery from intracytoplasmic stores in neurons of
acetylcholinesterase-deficient mice. Mol Cell Neurosci
23:121-33.
Saxena
A, Fedorko JM, Vinayaka CR, Medhekar R, Radic Z, Taylor P,
Lockridge O, Doctor BP (2003) Aromatic amino-acid residues
at the active and peripheral anionic sites control the
binding of E2020 (Aricept) to cholinesterases. Eur J Biochem
270: 4447-4458.
Nicolet Y, Lockridge O, Masson P, Fontecilla-Camps JC, Nachon F
(2003) Crystal structure of human butyrylcholinesterase and
of its complexes with
substrate and products. J Biol
Chem 278: 41141-41147.
Volpicelli-Daley LA, Hrabovska A, Duysen EG, Ferguson SM, Blakely
RD, Lockridge O, Levey AI (2003)
Altered Striatal Function And
Muscarinic Cholinergic Receptors In Acetylcholinesterase
Knockout Mice. Mol Pharmac 64: 1309-1316.
Masson
P, Goldstein BN, Debouzy JC, Froment MT, Lockridge O,
Schopfer LM (2004) Damped oscillatory hysteretic behaviour
of butyrylcholinesterase with benzoylcholine as substrate.
Eur J Biochem 271: 220-234.
Masson
P, Bec N, Froment MT, Nachon F, Balny C, Lockridge O,
Schopfer LM (2004) Rate-determining step of
butyrylcholinesterase-catalyzed hydrolysis of benzoylcholine
and benzoylthiocholine. Volumetric study of wild-type and
D70G mutant behaviour. Eur J Biochem 271: 1980-1990.
Wang Y,
Boeck AT, Duysen EG, Van Keuren M, Saunders T, Lockridge O
(2004) Resistance to organophosphorus agent toxicity in
transgenic mice expressing the G117H mutant of human
butyrylcholinesterase. Toxicol Appl Pharmacol 196:
356-366.
Wang
Y, Schopfer LM, Duysen EG, Nachon F, Masson P, Lockridge O
(2004) Screening assays for cholinesterases resistant to
inhibition by Organophosphorus toxicants. Anal Biochem 329:
131-138.
Schopfer LM, Boeck AT, Broomfield CA, Lockridge O. (2004)
Mutants of human butyrylcholinesterase with organophosphate
hydrolase activity; evidence that His117 serves as a
general base catalyst in the hydrolysis of echothiophate. J
Med Chem Defense 2: 1-21 (online publication)
Adler
M, Manley HA, Purcell AL, Deshpande SS, Hamilton TA, Kan KR,
Oyler G, Lockridge O, Duysen EG, Sheridan RE (2004) Reduced
acetylcholine receptor density, morphological remodeling,
and butyrylcholinesterase activity can sustain muscle
function in acetylcholinesterase knockout mice. Muscle
Nerve 30: 317-327.
Bytyqi
AH, Lockridge O, Duysen E, Wang Y, Wolfrum U, Layer PG
(2004) Impaired formaton of the inner retina in an AChE
knockout mouse results in degeneration of all
photoreceptors. Eur J Neurosci 20: 2953-2962.
Nachon
F, Asojo OA, Borgstahl G, Masson P, Lockridge O (2004) Role
of water in aging of human butyrylcholinesterase inhibited
by echothiophate. The crystal structure suggests two
alternative mechanisms of aging. Biochemistry. In press.
Peeples
ES, Schopfer LM, Duysen EG, Spaulding R, Voelker T, Thompson
CM, Lockridge O (2005) Albumin, a new biomarker of
organophosphorus toxicant exposure, identified by mass
spectroscopy. Tox Sci 83: 303-312
Lockridge O, Duysen EG, Voelker T, Thompson CM, Schopfer LM
(2005) Life without acetylcholinesterase: the implications
of cholinesterase inhibitor toxicity in AChE-knockout mice.
Environmental Toxicology and Pharmacology 19: 463-469.
Schopfer
LM, Voelker T, Bartels CF, Thompson CM, Lockridge O (2005)
Reaction kinetics of biotinylated organophosphorus
toxicant, FP-biotin, with human acetylcholinesterase and
human butyrylcholinesterase. Chem Res Toxicol 18: 747-754.
Saez-Valero
J, Perez de Gracia JA, Lockridge O (2005) Intraperitoneal
administration of 340 kDa human plasma butyrylcholinesterase
increases the level of the enzyme in the cerebrospinal fluid
(2005) Neuroscience Letters 383: 93-98.
Lockridge O, Schopfer LM, Winger G, Woods JH (2005) Large
scale purification of butyrylcholinesterase from human
plasma suitable for injection into monkeys; a potential new
therapeutic for protection against cocaine and nerve agent
toxicity. J Medical Chemical Biological & Radiological
Defense Volume 3, published online 1 Jul 2005.
Schopfer
LM, Champion MM, Tamblyn N, Thompson
CM, Lockridge O (2005) Characteristic Mass Spectral
Fragments of the Organophosphorus Agent FP-biotin and FP‑biotinylated
Peptides from Trypsin and Bovine Albumin (Tyr410). Anal
Biochem 345: 122-132.
Li B,
Sedlacek M, Manoharan I, Boopathy R, Duysen EG, Masson P,
Lockridge O (2005) Butyrylcholinesterase, paraoxonase, and
albumin esterase, but not carboxylesterase, are present in
human plasma. Biochem Pharmacol 70: 1673-1684.
Hrabovska A, Duysen EG, Sanders JD, Murrin LC, Lockridge O
(2005) Delivery of human acetylcholinesterase by adeno-associated
virus to the acetylcholinesterase knockout mouse. Chem Biol
Interact 157-158: 71-78.
Masson
P, Schopfer LM, Froment MT, Debouzy JC, Nachon F, Gillon E,
Lockridge O, Hrabovska A, Goldstein BN (2005) Hysteresis of
butyrylcholinesterase in the approach to steady-state
kinetics. Chem Biol Interact 157-158: 143-152.
Nachon
F, Asojo OA, Borgstahl G, Masson P, Lockridge O (2005)
Structural data on the aging of
diethylphosphoryl-butyrylcholinesterase. Chem Biol Interact
157-158: 408-409.
Li H,
Schopfer L, Spaulding R, Thompson CM, Lockridge O (2005)
Identification of organophosphate-reactive proteins by
tandem mass spectrometry. Chem Biol Interact 157-158:
383-384.
Li B,
Duysen EG, Poluektova LY, Murrin LC, Lockridge O (2006)
Protection from the toxicity of diisopropylfluorophosphate
by adeno-associated virus expressing acetylcholinesterase.
Toxicol Appl Pharmacol . Epub ahead of print.
De Jaco
A, Comoletti D, Kovarik Z, Gaietta G, Radic Z, Lockridge O,
Ellisman MH, Taylor P (2006) A mutation linked with autism
reveals a common mechanism of endoplasmic reticulum
retention for the alpha, beta hydrolase-fold protein
family. J Biol Chem. Epub ahead of print.
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