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Physiology
William G. Mayhan, Ph.D.
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ACADEMIC DEGREES:
Graduate school: University of Nebraska Medical Center (1983)
Post-doctoral training: Department of Internal Medicine;
University of Iowa
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Contact Name: Dr. William G. Mayhan
Phone Number: (402) 559-5329
e-mail address: wgmayhan@unmc.edu
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April 2005
through March 2009
National Institutes of Health
Cerebral Microcirculation During Alcohol Consumption
Direct Costs: $875,000
Principal Investigator
October 2004
through September 2008
National Institutes of Heath
Cerebrovascular Disease in Type 1 Diabetes
Direct Costs: $1,000,000Principal Investigator
July 2001
through June 2007
National Institutes of Health
Nicotine-Induced Cerebrovascular Dysfunction
Direct Costs:
$625,000
Principal
Investigator
August 2004
through July 2009
National Institutes of Health
Program Project Grant
Neuro-Circulatory Function in Chronic Heart Failure
Core 2: Molecular Biology, Biochemistry and Histology Core
Co-Investigator: 10% effort. (Irving H. Zucker-P.I.)
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Sun, H., and
Mayhan, W.G.: Temporal effect of alcohol consumption on reactivity of pial
arterioles: role of oxygen radicals. Am. J. Physiol. 280:
H992-H1001, 2001.
Sun, H., and
Mayhan, W.G.: Superoxide dismutase ameliorates impaired dilatation of the
basilar artery during chronic alcohol consumption. Brain Res. 891:
116-122, 2001.
Mayhan, W.G.,
Trauernicht, A.K., and Irvine, S.D.: Insulin reverses impaired
acetylcholine-induced dilatation of the rat basilar artery during diabetes
mellitus. Brain Res. 893: 195-201, 2001.
Mayhan, W.G.,
and Sharpe, G.M..: Generation of superoxide anion impairs histamine-induced
increases in macromolecular efflux. Microvasc. Res. 61: 275-281,
2001.
Sun, H.,
Patel, K.P., and Mayhan, W.G.: Tetrahydrobiopterin, a co-factor for nitric
oxide synthase, improves endothelial dysfunction during chronic alcohol
consumption. Am. J. Physiol. 281: H1863-H1869, 2001.
Li, Y.F.,
Mayhan, W.G., and Patel, K.P.: NMDA-mediated increase in renal sympathetic
nerve discharge within the PVN: role of nitric oxide. Am. J. Physiol.
281: H2328-H2336, 2001.
Mayhan, W.G.:
Cellular mechanisms by which tumor necrosis factor produces disruption of
the blood-brain barrier. Brain Res. 927: 144-152, 2002.
Sun, H.,
Patel, K.P., and Mayhan, W.G.: Impairment of neuronal nitric oxide synthase-dependent
dilatation of cerebral arterioles during chronic alcohol consumption.
Alcoholism: Clin. and Exp. Res. 26: 663-670, 2002.
Mayhan, W.G.,
and Sharpe, G.M.: Acute and chronic treatment with nicotine impairs
reactivity of arterioles in response to activation of potassium channels.
J. Cardiovasc. Pharmacol. 39: 695-703, 2002.
Mayhan, W.G.,
Sun, H., and Irvine, S.D.: Influence of gender on dilatation of the basilar
artery during diabetes mellitus. Brain Res. 930: 182-190, 2002.
Prall,A.K.,
Longo, G.M., Mayhan, W.G., Waltke, E.A., Fleckten,B., and Baxter, B.T.:
Doxycycline in patients with abdominal aortic aneurysms and in mice:
Comparison of serum levels and effect on aneurysm growth in mice. J. Vasc.
Surg. 35: 923-929, 2002.
Zheng, H.,
Li, Y.F., Weiss, M., Mayhan, W.G., and Patel, K.P.: Neuronal expression of
fos protein in the forebrain of diabetic rats. Brain Res. 956:
268-275, 2002.
Fang, Q.,
Sun, H., and Mayhan, W.G.: Impairment of nitric oxide synthase-dependent
dilatation of cerebral arterioles during infusion of nicotine. Am. J.
Physiol. 284: H528-H534, 2003.
Sun, H.,
and Mayhan, W.G.: Glutathione improves impaired nitric oxide synthase-dependent
responses of cerebral arterioles during chronic alcohol consumption.
Alcohol Res. 8: 55-60, 2003.
Trauernicht, A.K., Sun, H., Patel, K.P., and Mayhan, W.G.: Enalapril
prevents impaired nitric oxide synthase-dependent dilatation of cerebral
arterioles in diabetic rats. Stroke 34: 2698-2703, 2003.
Li, Y.F.,
Mayhan, W.G., and Patel, K.P.: Role of the paraventricular nucleus in
renal excretory responses to acute volume expansion: role of nitric
oxide. Am. J. Physiol. 285: H1738-H1746, 2003.
Schwaninger, R.M., Sun, H., and Mayhan, W.G.: Impaired nitric oxide
synthase-dependent dilation of cerebral arterioles in Type II diabetic
rats. Life Sci. 73: 3415-3425, 2003.
Fang, Q.,
Sun, H., and Mayhan, W.G.: L-arginine prevents impaired
endothelium-dependent cerebral arteriolar dilatation during acute
infusion of nicotine. Nicotine and Tobacco Res. 6: 1009-1014,
2004.
Mayhan,
W.G., Mayhan, J.F., and Sun, H.: Influence of exercise on dilatation of
the basilar artery during diabetes mellitus. J. Appl. Physiol.
96:
1730-1737, 2004.
Yarnitsky,
D., Gross, Y., Lorian, A., Shalev, A., Lamensdorf, I., Bornstein, R.,
Vet, D., Shorer, S., Mayevsky, A., Patel, K.P., Abbott, N.J., and Mayhan,
W.G.: Blood-brain barrier opened by stimulation of the parasympathetic
sphenopalatine ganglion: a new method from macromolecular delivery to
the brain. J. Neurosurg. 101: 303-309, 2004.
Mayhan,
W.G., Mayhan, J.F., and Sun, H.: In vivo properties of potassium
channels in cerebral blood vessels during diabetes mellitus.
Microcirculation 11: 605-613, 2004.
Sun, H.,
Fang, Q., and Mayhan, W.G.: Inward rectifier potassium channels in the
basilar artery during chronic alcohol consumption. Alcoholism: Clin.
and Exp. Res. 28: 1557-1561, 2004.
Sun, H.,
Fang, Q., and Mayhan, W.G.: Sex differences in nitric oxide synthase-dependent
dilatation of cerebral arterioles during long-term alcohol consumption.
Alcoholism: Clin. and Exp. Res. 29: 430-436, 2005.
Trickler,
W.J., Mayhan, W.G., and Miller, D.W.: Brain microvessel endothelial
cell response to tumor necrosis factor-alpha involves a nuclear factor
kappa B (NF-kb)
signal transduction pathway. Brain Res. 1048: 24-31, 2005.
Sun, H.,
Zheng, H., Molacek, E., Fang, Q., Patel, K.P., and Mayhan, W.G.: Role
of NAD(P)H oxidase in alcohol-induced impairment of endothelial nitric
oxide synthase-dependent dilation of cerebral arterioles. Stroke
37:
495-500, 2006.
Fang,Q.,
Sun, H., Arrick, D.M., and Mayhan, W.G.: Inhibition of NAD(P)H oxidase
improves impaired reactivity of pial arterioles during chronic exposure
to nicotine. J. Appl. Physiol. 100: 631-636, 2006.
Sun, H.,
Molacek, E., Zheng, H., Fang, Q., Patel, K.P., and Mayhan, W.G.:
Alcohol-induced impairment of neuronal nitric oxide synthase (nNOS)-dependent
dilation of cerebral arterioles: Role of NAD(P)H oxidase. J. Molecular
and Cell. Cardiol. 40: 321-328, 2006.
Li, Y-F.,
Wang, W., Mayhan, W.G., and Patel, K.P.: Angiotensin-mediated increase
in renal sympathetic nerve discharge with the PVN: Role of nitric
oxide. Am. J. Physiol. (In press).
Zheng,
H., Mayhan, W.G., Bidasee, K.R., and Patel, K.P.: Blunted nitric
oxide-mediated inhibition of sympathetic nerve activity within the
paraventricular nucleus in diabetic rats. Am. J. Physiol. (In press).
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PREVIOUS
GRADUATE STUDENTS/POST-DOCTORAL FELLOWS (present location):
Ph.D. Students
Shuh-Tsong Yang (1991). Associate
Professor, Taipei, Taiwan.
Margaret Murray (1992). Deceased.
Tan Yong (1991).
Sean Didion (1996). Assistant Professor, University of Iowa.
Post-Doctoral Fellows
X. Gao, M.D. (1990-93). Department of Pharmacology,
University of Illinois, Chicago.
Hong Sun, M.D., Ph.D. (1999-present).
Department of Cellular and Integrative Physiology, UNMC.
Qin Fang, MD., Ph.D. (2000-2006). Department of Pediatrics, University of
Arizona.
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Dr. Mayhan's research interests revolve around examining
the role of the endothelium in the regulation of vascular permeability and
reactivity of the peripheral and cerebral microcirculations during
pathophysiologic conditions. Thus, experiments examine the role of various
second messenger systems in the control of vascular permeability under basal
and agonist-induced conditions, and in the control of vascular reactivity
during various disease states such as diabetes, hypertension, alcoholism,
and heart failure.
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In vivo microscopy, fluorescence microscopy, molecular
biology techniques.
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