Therapeutic Applications of Microbubbles - Phase II, NIH STTR Phase II
(Small Business Technology Transfer Program), PI: Thomas R. Porter, MD,
Applicant Organization: AVI Biopharma, Corvallis, OR, 9/30/00 - 8/31/02,
$753,891.
The CADET
Trial: Contrast Assisted Dobutamine Echo Trial: Detection of Coronary
Stenoses with Intravenous Dobutamine Stress Contrast Echocardiography:
Incremental Benefit of Myocardial Perfusion Over Wall Motion Analysis,
Amersham Health Inc., 6/02 – 5/03, $93,667 (clinical grant), PI: Thomas R.
Porter, MD
The CADET Trial: Contrast
Assisted Dobutamine Echo Trial: Detection of Coronary Stenoses with
Intravenous Dobutamine Stress Contrast Echocardiography: Incremental Benefit
of Myocardial Perfusion Over Wall Motion Analysis, Amersham Health Inc.,
6/02 – 5/03, $307,725 (multi-center grant), PI: Thomas R. Porter, MD
Prevention of Ischemic Left
Ventricular Dysfunction with Intravenous Perfluorocarbon Containing
Microbubbles, Max Baer Fraternal Order of Eagles, 7/02 – 6/03, $5,000, PI:
Thomas R. Porter, MD
Inhibition of Intracoronary
Stent-induced Intimal Hyperplasia with Targeted Microbubbles Carrying the
E2F Decoy Oligonucleotide, University of Nebraska Medical Center-Gene
Therapy Program, 8/02 – 7/03, $15,000, PI: Thomas R. Porter, MD
Non-invasive Recanalization of
Intracoronary Thrombi with Intravenous Microbubbles, ImaRx Therapeutics,
Inc., 4/03 – 9/03, $81,300, PI: Thomas R. Porter, MD
An Open-Label, Randomized,
Phase IV Trial to Determine the Accuracy of Definity-enhanced
Echocardiography During Dipyridamole Stress to Localize Perfusion
Abnormalities in Subjects with Suspected or Known Coronary Artery Disease,
Bristol-Myers Squibb Medical Imaging, 5/03 – 10/03, $163,296, PI: Thomas R.
Porter, MD
An Open-Label, Non-Randomized,
Phase IV, Follow-up Trial to Compare Infusion Dosing Against Bolus Dosing
for Use in Definity-Enhanced Rest and Dipyridamole Stress Echocardiography
for the Detection and Localization of Perfusion Abnormalities (DMP 115-908),
Bristol-Myers Squibb Medical Imaging, 7/03 – 12/03, $22,500, PI: Thomas
R.Porter,MD
Treatment of Thrombosed
Anteriovenous Shunts with Intravenous PCMB and Low Frequency Ultrasound in a
Canine Model, ImaRx Therapeutics, Inc., 2/03 – 2/04, $64,704, PI: Thomas R.
Porter, MD
Alterations in Blood Brain
Barrier Permeability Following Intravenous Injections of Microbubbles During
Transcranial Ultrasound, The Sanfilippo Syndrome Medical Research
Foundation, 10/03 – 3/04, $19,840, PI: Thomas R Porter, MD
Detection of Coronary Artery
Disease with a Continuous Infusion of Definity Ultrasound Contrast During
Adenosine Stress Echocardiography, Fujisawa Healthcare Inc., 1/04 – 6/05,
$127,036, PI: Thomas R. Porter, MD
An Open Label, Non-Randomized,
Phase IV Trial to Compare Definity-Enhanced Rest and Dipyridamole Stress
Echocardiography to Nuclear Perfusion Imaging for the Detection and
Localization of Perfusion Abnormalities, Bristol-Myers Squibb Medical
Imaging, 4/04 – 11/04, $131,544, PI: Thomas R. Porter, MD
A Phase 1b, Randomized, Single
Blind Study Evaluating Resten-MP (AVI-4126 Bound to Perfluorocarbon Exposed
Sonicated Dextrose Albumin) in Subjects with Focal De Novo Stenosis, AVI
BioPharma Inc., 6/04 – 5/05, $541,946, PI: Thomas R. Porter, MD
Microbubble Potentiated
Ultrasound as a New Method of Declotting Thrombosed Dialysis Grafts, ImaRx
Therapeutics Inc., 5/04 – 4/05, $158,926, PI: Thomas R. Porter, MD
A Chronic Study of
Non-invasive Recanalization of Intracoronary Thrombi with Ultrasound and
Intravenous Microbubbles, ImaRx Therapeutics Inc., 5/04 – 4/05, $199,495,
PI: Thomas R. Porter, MD
Blinded reader on Phase 3
AI-700 rest/stress imaging Studies for Acusphere, 8/04 – 9/05, $28,000, PI:
Thomas R. Porter, MD
The Mechanism for Improved Ultrasound
Contrast with Intermittent Imaging, American Heart Association, 7/1/97 B
6/30/99, $38,992, PI: Thomas R. Porter, MD
Therapeutic Application of Perfluorocarbon
Microbubbles, NIH STTR Phase I (Small Business Technology Transfer Program,
7/1/98 B 6/30/99, $49,955. PI: Patrick L. Iversen, Ph.D.; Co-PI: Thomas R.
Porter, MD
An Open-Label Phase 2 Study to Compare
Optison Myocardial Contrast Echocardiography (MCE) to Single Photon Emission
Computed Tomography (SPECT) for the Detection of Ischemia in Patients
Undergoing Exercise Stress, Molecular Biosystems Inc.; 11/98 B 10/99,
$186,111, Thomas R. Porter, MD
Determining the Optimal Ultrasound
Parameters for Microbubble-Mediated Gene Uptake in Human Coronary Arteries,
American Heart Association Nebraska Grant-in-Aid, 7/1/99 B 6/30-01, $34,911,
Thomas R. Porter, MD
An Open-Label, Non-randomized, Phase II,
Single Center Trial to Evaluate the Ability of DMP 115-Enhanced
Echocardiographic Evaluation of Wall Motion and Perfusion Abnormalities (at
Rest and During Treadmill Exercise Stress) Using Accelerated Intermittent
Harmonic Imaging Acquisition Techniques to Detect Coronary Artery Disease in
Subjects with Suspected Disease, DuPont Pharmaceuticals Company, 8/99 B
2/00, $56,670, Thomas R. Porter, MD
Determining the Optimal Ultrasound
Parameters for Microbubble-mediated Gene Uptake in Human Coronary Arteries,
American Heart Association Nebraska Grant-in-Aid, 7/99 - 6/01, $69,911,
Thomas R. Porter, MD
Therapeutic Applications of Microbubbles -
Phase II, NIH STTR Phase II (Small Business Technology Transfer Program),
PI: Thomas R. Porter, MD, Applicant Organization: AVI Biopharma, Corvallis,
OR, 9/30/00 - 8/31/02, $753,891.
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Culp WC, Porter TR,
Culp Jr, WC, Vonk BN. Carbon Dioxide in the Aortic Arch: Swine Studies of
Detection, Hemodynamics, Physiologic Implications, and Rescue Maneuvers.
Cardiovasc Intervent Radiol.
2003;26:128-135.
Ronderos
RE, Boskis M, Chung N, Corneli DB, Escudero EM, Ha JW, Charlante C, Rim S-J,
Portis M, Fabris N, Camilletti J, Mele AA, Otero F, Porter TR.
Correlation
between Mycardial Perfusion Abnormalities Detected with Intermittent Imaging
Using Intravenous Perfluorocarbon Microbubbles and Radioisotope Imaging
during High-Dose Dipyridamole Stress Echo. Clin Cardiol
2002;25:103-111.
Culp W, Porter TR,
McCowan TC, Roberson PK, James CA, Matchett WJ, Moursi M. Microbubble-augmented
Ultrasound Declotting of Thrombosed Arteriovenous Dialysis Grafts in Dogs.
J Vasc Interv Radiol 2003;14:343-347.
Porter TR,
Xie F. Part II: Recent Advances in Myocardial Contrast Echocardiography,
Clinical Experience in the Detection of Coronary Artery Disease with
Myocardial Contrast Echocardiography. Echocardiography
2002;19:399-407.
Khankirawatana B,
Khankirawatana S, Lof J, Porter T. Left Atrial Volume Determination
by Three-Dimensional Echocardiography Reconstruction: Validation and
Application of a Simplified Technique. J Am Soc Echocardiogr
2002;15:1051-6.
Sonne C, Xie F, Lof J,
Oberdorfer J, Phillips P, Everbach EC, Porter TR. Differences in
Definity and Optison Microbubble Destruction Rates at a Similar Mechanical
Index with Different Real Time Perfusion Systems. J Am Soc Echocardiogr
2003;16:1178-85.
Porter TR,
McGrain A, Oehlke H, Xie F. Should the Dobutamine Stress Test Include
Myocardial Contrast Echocardiography? Cardiac Ultrasound TODAY
2003;9(2):27-34.
Culp WC, Porter TR,
Culp WC Jr, Vonk BN. Carbon Dioxide in the Aortic Arch: Coronary Effects and
Implications in a Swine Study. Cardiovasc Intervent Radiol
2003;26:128-135.
Porter TR,
Oberdorfer J, Rafter P, Lof J, Xie F. Microbubble Responses to the Similar
Mechanical Index with Different Real Time Perfusion Imaging Techniques.
US Med Biol 2003;29:1187-1192.
Porter TR,
O’Leary E, Silver M, Oehlke H, Xie F. A Method of Detecting and Quantifying
Severity of Myocardial
Perfusion Defects With Intravenous Ultrasound Contrast and Breath Holding
During Stress Echocardiography. Echocardiography 2003;20:411-422.
Elhendy A, Windle J,
Porter TR. Safety and Feasibility of Dobutamine Stress
Echocardiography in
Patients with Implantable Cardioverter Defibrillator. Am J Cardiol
2003;92:475-477.
Stambler BS,
Ellenbogen KA, Zhang X, Porter TR, Xie F, Malik R, Small R, Burke M,
Kaplan A, Nair L, Belz M, Fuenzalida C, Gold M, Love C, Sharma A, Silverman
R, Sogade F, Van Natta B, Wilkoff BL. Right Ventricular Outflow Versus
Apical Pacing In Pacemaker Patients With Congestive Heart Failure And atrial
Fibrillation. Journal of Cardiovascular Electrophysiology
2003;14:1180-1186.
Kipshidze N, Porter
TR, Dangas G, Yazdi H, Tio F, Xie F, Hellinga D, Fournadijev J, Wolfram
R, Seabron R, Waksman R, Abizaid A, Roubin G, Iyer S, Leon MB, Iversen P,
Moses JW. Systemic Targeted Delivery Of Antisense With Perflourobutane Gas
Microbubble Carrier Reduced Neointimal Formation In The Procine Coronary
Restonsis Model. Cardiovascular Radiation Medicine 2003;4:152-9.
Khankirawatana B,
Khankirawatana S, Porter TR. How Should Left Atrial be Reported?
Comparative Assessment with Use of Multiple Echocardiographic Methods. Am
Heart J 2004;147:369-74.
Elhendy A, O’Leary E,
Xie F, McGrain A, Porter TR. Comparative Accuracy of Real Time
Myocardial Contrast Perfusion Imaging and Wall Motion Analysis During
Dobutamine Stress Echocardiography for the Diagnosis of Coronary Artery
Disease. J Am Coll Cardiol 2004;44 2185-2191.
Khankirawatana B,
Khankirawatana S, Peterson B, Oehlke H, Porter TR. Peak Atrial
Systolic Mitral Annular Velocity by Dopple Tissue Reliably Predicts Left
Atrial Systolic Function. J Am Soc Echocardiogr. 2004;17:353-360.
Tsutsui J, Xie F,
O’Leary EL, Elhendy A, Anderson JR, McGrain AC, Porter TR. Diagnostic
Accuracy and Prognostic Value of Dobutamine Value of Stress Myocardial
Contrast Echocardiography in Patients with Suspected Acute Coronary
Syndromes. Echocardiography 2004; 44:2185-2191.
Unger EC, Porter TR,
Culp William, Labell R, Matsunaga T, Zutshi R. Therapeutic applications of
lipid-coated microbubbles. J. Advanced Drug Delivery Reviews 2004;56:
1291-1314.
Tsutsui JM, Porter
TR. Diagnostic Applications of Intravenous Microbubbles. Cardiac
Ultrasound TODAY 2004;10:35-46.
Tsutsui JM, Xie F,
Cano M, Chomas J, Phillips P, Radio SJ, Lof J, Porter TR. Detection
of retained microbubbles in carotid arteries with real-time low mechanical
index imaging in the setting of endothelial dysfunction. J Am Coll
Cardiol 2004; 44:1036-1046
Culp W C, Porter T
R, Lowery J, Xie F, Roberson PK, Marky L. Intracranial Clot Lysis with
Intravenous Microbubbles and Transcranial Ultrasound in Swine. Stroke
2004;35:2407-2411
Khankirawatana B,
Khankirawatana S, Mahrous H, Porter TR. Assessment of papillary
muscle function using myocardial velocity gradient derived from tissue
Doppler echocardiography. Am J Cardiol 2004; 93: 45-49.
Tsutsui JM, Grayburn
PA, Xie F, Porter TR. Drug and gene delivery and enhancement of
thrombolysis using ultrasound and microbubbles. Cardiol Clin 2004;
22:299-312.
Tsutsui JM, Xie F,
McGrain AC, Mahrous H, Hankins J, O’Leary EL, Porter Thomas R.
Comparison of Low-Mechanical Index Pulse Sequence Schemes for Detecting
Myocardial Perfusion Abnormalities During Vasodilator Stress
Echocardiography. American Journal of Cardiology 2005 (In
Press)
Porter TR,
Tsutsui JE, Elhendy A, Xie F, O’Leary E, McGrain A. Safety and Feasibility
of Dobutamine Stress Myocardial Contrast Perfusion Imaging. J Am Coll
Cardiol. 2005 (In Press)
Porter T.
Diagnostic and Therapeutic Utilization of Microbubbles. Chinese Taipai
Society of Ultrasound in Medicine 2004 (In Press).
Tsutsui JM, Xie F,
Porter TR. The use of microbubbles to target drug delivery.
Cardiovascular Ultrasound 2004; 2:23.
Tsutsui J, Xie F,
O’Leary EL, Elhendy A, Anderson D, McGrain AC, Porter TR.
“Diagnostic Accuracy and Prognostic Value of Dobutamine Stress Myocardial
Contrast Echocardiography in Patients with Suspected Acute Coronary
Syndromes”. Echocardiography. 2005(In Press).
Elhendy A, Ginete W,
Shurmur S, Porter TR. Acute myocardial infarction after a negative
dobutamine stress echocardiogram. Eur J Echocardiography.
2004;5:469-471.
Kipshidze NN,
Porter TR, Dangas G, Yazdi H, Tio F, Xie F, Hellinga D, Wolfram R,
Seabron R, Waksman R, Abizaid A, Roubin G, Iyer S, Colombo A, Leon MB,
Moses, J. “Novel Site-Specific Systemic Delivery of Rapamycin with
Perfluorobutane Gas Microbubble Carrier Reduced Neointimal Formation in a
Porcine Coronary Restenosis Model”.Catheter Cardiovasc Interv. 2005
(In Press).
Tsutsui J, Elhendy A,
Anderson JR, Xie F, McGrain AC, Porter TR. “Prognostice Value of
Dobutamine Stress Myocardial Contrast Perfusion Echocardiography”.
Submitted to Circulation January 26, 2005.
Xie, F, Tsutui JM,
McGrain AC, DeMaria A, Cotter B, Becher H, LeBleu C, Labovitz A, Picard MH,
Porter TR. “Comparison of Dobutamine Stress Echo With and Without
Real Time Perfusion Imaging in the Detection of Coronary Artery Disease”.
Submitted to American Journal of Cardiology January 2005.
Porter TR,
Xie F, Knapp D, Iversen P, Marky LA, Tsutsui JM, Maiti S, Lof J, Radio SJ,
Kipshidze N. “Targeted Vascular Delivery of Antisense Molecules Using
Intravenous Microbubbles” Submitted to Nature Biotechnology.
February 2005.
Kipshidze NN, Porter TR,
Dangas G, Yazdi H, Tio F, Xie F, Hellinga D, Wolfram R, Seabron R,
Waksman R, Abizaid A, Roubin G, Iyer S, Colombo A, Leon MB, Moses JW,
Iversen P. Novel site-specific systemic delivery of Rapamycin with
perfluorobutane gas microbubble carrier reduced neointimal formation in a
porcine coronary restenosis model.
Catheter Cardiovasc Interv.
2005 64:389-394 [Epub ahead of print].
Porter, TR; Li, S; Kilzer, K; Deligonul, U.
The Effect of a Residual Stenosis by Quantitative Angiography on the
Myocardial Contrast Defect Observed Following Coronary Reperfusion Using
Intermittent Harmonic Ultrasound Imaging and Intravenous Perfluorocarbon
Ultrasound Contrast. Echocardiography 16:785-797, 1999.
Porter, TR; Li, S; Jiang, L; Grayburn, P;
Deligonul, U. Real Time Visualization of Myocardial Perfusion and Wall
Thickening in Humans with Intravenous Ultrasound Contrast and Accelerated
Intermittent Harmonic Imaging. J Am Soc Echocardiogr 12:266-271,
1999.
Porter, T; Xie, F; Li, S; Kricsfeld, D;
Deligonul, U. Effect of Transducer Standoff on the Detection, Spatial
Extent, and Quantification of Myocardial Contrast Defects Caused by Coronary
Stenoses. J Am Soc Echocardiogr 12:951-60, 1999.
Tiemann, K; Lohmeier, S; Kuntz, S; Koster, J;
Pohl, C; Burns, P; Porter, T; Nanda, N; Luderitz, B; Becher, H. Real-Time
Contrast Echo Assessment of Myocardial Perfusion at Low Emission Power-
First Experimental and Clinical Results Using Power Pulse Inversion Imaging.
Echocardiography 16:799-809, 1999.
Arruda, ALM; Ozorio, A; Mattos, E; de
Andrade, JL; Porter, T; Mathias, W. Hypoperfusion of the Left Ventricle in
the Absence of Changes in Segmental Contractility as Observed through
Echocardiography by Using Microbubbles During Dobutamine Infusion. Arq
Bras Cardiol 72:722-26, 1999.
Mukherjee, D; Wong, J; Griffin, B; Ellis, SG;
Porter, T; Sen, S; Thomas JD. Ten Fold Augmentation of Myocardial Uptake of
Vascular Endothelial Growth Factor with Ultrasound after Systemic
Administration. J Am Coll Cardiol 2000;35:1678-1686.
Porter, TR. Clinical Experience in the
Detection of Coronary Artery Disease with Myocardial Contrast
Echocardiography. Echocardiography 2000 (invited).
Cwaig, J; Xie, F; O’Leary, E; Kricsfeld, D;
Dittrich, H; Porter, TR. Detection of Angiographically Significant Coronary
Artery Disease with Accelerated Intermittent Imaging after Intravenous
Administration of Ultrasound Contrast Material. Am Heart J
139:675-683, 2000
Porter, TR. Improving the Evaluation of Left
Ventricular Systolic Function with Intravenous Perfluorocarbon Ultrasound
Contrast: Will Suboptimal Echocardiograms Become an Endangered Species? J
Am Coll Cardiol February 35:491-2, 2000.
Porter, TR. Role of Intravenous Ultrasound
Contrast in Stress Echocardiography. Echocardiography 17:92-9,
2000.
Porter, T; Xie, F. Applications of Contrast
Echocardiography to Ischemic Heart Disease. The Circulation Frontier
4:42-51, 2000.
Culp, WC, Porter, TR, Xie, F, Goertzen, TC,
McCowan, TC, Vonk, BN, Baxter, BT. Microbubble Potentiated Ultrasound as a
Method of Declotting Thrombosed Dialysis Grafts. Circulation 2000
(submitted).
Porter, TR, Xie, F, Silver, M, Kricsfeld, D,
O=Leary, E. Real Time Perfusion Imaging with a Low Mechanical Index Pulse
Inversion Doppler. J Am Coll Cardiol 2000 (submitted).
Porter, TR, Hiser, W, Kricsfeld, D, Deligonul,
U, Xie, F, Iversen, P, Radio, S. Inhibition of Carotid Artery Neonintimal
Formation with Intravenous Microbubbles. Ultrasound In Med and Biol
2000 (accepted, in press).
Shimoni, S, Zoghbi, WA, Xie, F, Kricsfeld, D,
Iskander, S, Gober, L, Mikati, IA, Verani, MS, O=Leary, EL, Porter, TR. Real
Time Assessment of Myocardial Perfusion and Wall Motion During Bicycle and
Treadmill Exercise Echocardiography: Comparison with Single Photon Emission
Computed Tomography. J Am Coll Cardiol 2000 (accepted; in press).
Porter, TR, Everbach, C, Kricsfeld, D, Xie F. Myocardial Cavitational
Activity During Continuous Infusion and Bolus Intravenous Injections of
Perfluorocarbon Containing Microbubbles. J Am Soc Echocardiogr 2000
(accepted; in press).
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