Extramural:
2002-2005: Department of Veterans Affairs, “Pathogenesis of Orthopedic
Prosthetic Device Infections” Co-PI: M.E. Rupp (P.I. K. Garvin)
2002-2006: NIH-NIAID, “ica phase
variation in Staphylococcus epidermidis” Co-I: M.E. Rupp (P.I.
Fey)
2005-2007: NIH-NIAID, “Population
Genetics Analysis on West Nile Virus” Project PI: Mark Loeb, McMaster
University; UNMC site PI: M.E. Rupp.
Investigator Initiated, Industrial:
2001: Hand Hygiene in the ICU: An Outcomes Research Program. Gojo, Inc.
P.I. M.E. Rupp
2004: Characterization of Daptomycin-Resistant
Staphylococcus aureus, Cubist Pharmaceuticals, P.I. M.E. Rupp,
Pending
2005: Effect of Introduction of a
Safety-Engineered Blood Collection Set on Activation Compliance and
Sharps Injuries, Becton, Dickinson, & Co. P.I. M. E. Rupp.
Industry Initiated:
2000: Multicenter, double-blind, placebo-controlled, randomized, phase
III study of Tifacogin in severe sepsis. Chiron Corp, P.I. ME Rupp
2002: Phase 3, multicenter, randomized,
open-label, comparative study to assess the safety and efficacy of
daptomycin compared to conventional therapy in the treatment of subjects
with infective endocarditis and complicated bacteremia due to
Staphylococcus aureus. Cubist Pharmaceuticals, P.I. ME Rupp
2003: A Multicenter, double-blind,
randomized, comparison study of the efficacy and safety of tigecycline
to imipenem/cilastatin to treat complicated intra-abdominal infections
in hospitalized subjects. Wyeth Pharmaceuticals, P.I. ME Rupp
2003: Initial Safety and Pharmacokinetic
Trial of Immune Globin to Staphylococcus aureus Capsule Polysaccharide (Altastaph)
in Subjects with Persistent S. aureus Bacteremia. NABI
Biopharmaceuticals, P.I ME Rupp.
2005: Multicenter, Randomized Trial
Comparing the Moisture Handling Ability of Two Central Venous Catheter
Transparent Adhesive Dressings During Diaphoretic Episodes, 3M Health
Care, P.I. ME Rupp.
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Rupp ME, Fey PD, Longo GM. Effect of LY333328
against vancomcyin-resistant Enterococcus faecium in a rat
central venous catheter model. Journal Antimicrobial Chemotherapy.
47:705-07, 2001.
Rupp ME, Fey PD, Heilmann C, Gotz F.
Characterization of the importance of
Staphylococcus
epidermidis
polysaccharide intercellular adhesin and autolysin in the pathogenesis
of intravascular catheter-associated infection in a rat model. Journal
of Infectious Diseases 183:1038-42, 2001.
Fowler VG, Fey PD, Reller LB, Chamis A, Corey GR, Rupp
ME. The intercellular adhesin locus ica is present in
clinical isolates of Staphylococcus aureus from bacteremic
patients with infected and uninfected prosthetic joints. Journal of
Microbiology and Immunology, 189:127-131, 2001.
Rupp ME, Marion N, Fey PD, Bolam DL, Iwen PC,
Overfelt CM, Chapman L. Outbreak of vancomycin-resistant enterococci in
a neonatal intensive care unit. Infection Control and Healthcare
Epidemiology. 22:301-03, 2001.
Olsen KM, Rebuck J, Rupp ME. Arthralgias and
myalgias associated with Quinupristin/Dalfopristin administration.
Clinical Infectious Diseases. 32:e83-86, 2001.
Rupp ME, Fey PD. In-vivo models to evaluate
adhesion and biofilm formation by Staphylococcus epidermidis.
Methods in Enzymology. 336:206-215, 2001.
Veligandla SR, Hinrichs SH, Rupp ME, Lien EA, Neff
JR, Iwen PC. Delayed diagnosis of osseous Blastomycosis in two patients
following environmental exposure in non-endemic areas. American Journal
of Clinical Pathology. 118:536-41, 2002.
Iwen PC, Hinrichs SH, Rupp ME. Utilization of the
internal transcribed spacer regions as molecular targets to detect and
identify fungal pathogens. Medical Mycology. 40:87-109, 2002.
Carver PL, Nicolau DP, Rupp ME, Turner AL .
American Pharmaceutical Association Special Report: Combating Antibiotic
Resistance. 1-20, 2001.
Caratoli A, Tosini F, Giles WP, Rupp ME, Hinrichs
SH, Angulo FJ, Barrett TJ, Fey PD. Characterization of plasmids carrying
CMY-2 from expanded-spectrum cephalosporin-resistant Salmonella isolated
in the United States between 1996 and 1998. Antimicrobial Agents and
Chemotherapy. 46:1269-1272, 2002.
Fey PD, Salim B, Rupp ME, Hinrichs SH, Boxrud
DJ, Davis CC, Kreiswirth BN, Schlievert PM. Comparative molecular
analysis of community-acquired methicillin-resistant Staphylococcus
aureus and hospital-acquired methicillin-resistant Staphylococcus
aureus. Antimicrobial Agents and Chemotherapy. 47:196-203, 2003.
Rupp ME, Fey PD. Extended spectrum β-lactamase (ESBL)-producing
Enterobacteriaceae: considerations for diagnosis, prevention, and
drug treatment. Drugs. 63:353-365,2003.
Rupp ME, Medcalf SJ, Fey PD, Handke LD, Marion ND.
Monsel’s solution: A potential vector for nosocomial infection?
Infection Control and Hospital Epidemiology. 24:142-144, 2003.
Ayi BS, Rupp ME, Preheim L. Case Report: Man with
fever, confusion, and a red hand. MD Consult Infectious Diseases.
Available at:
http://www.mdconsult.com (July 15, 2003).
Fey PD, Rupp ME. Molecular epidemiology in the
public health and hospital environments. Clinics in Laboratory Medicine.
23:885-891, 2003.
Handke L, Conlon KM, Slater SR, Elbaruni S, Fitzpatrick
F, Humphreys H, Giles WP, Rupp ME, Fey PD, O’Gara JP. Genetic and
Phenotypic analysis of phenotypic variation in multiple
Staphylococcus epidermidis isolates. J Medical Microbiology.
53:367-374, 2004.
Rupp ME, Craig R. Prevention of Central Venous
Catheter Infections. Infections in Medicine. 21:123-127, 2004.
Olsen KO, Rudis MI, Rebuck JA, Hara J, Gelmont D, Ramin
M, Nelson C, Rupp ME. Effect of once daily dosing vs. multiple
daily dosing of tobramycin on enzyme markers of nephrotoxicity.
Critical Care Medicine. 32:1678-1682, 2004.
Rupp ME, Fitzgerald T, Marion N, Helget V, Puumala
S, Anderson JR, Fey PD. Effect of silver-coated urinary catheters:
efficacy, cost-effectiveness, and antimicrobial resistance. American
Journal of Infection Control. 32:445-450, 2004.
Rupp ME, Lisco S, Lipsett P, Perl T, Keating K,
Civetta J, Mermel L, Lee D, Dellinger EP, Donahoe M, Giles D, Pfaller M,
Maki DG, Sherertz R. Effect of a second-generation chlorhexidine/silver
sulfadiazine-impregnated central venous catheter on catheter-associated
infections in intensive care unit patients. A randomized,
double-blinded, controlled trial. Annals of Internal Medicine,
Accepted.
Wong ES, Rupp ME,
Mermel L, Perl TM, Bradley S, Ramsey KM, Ostrowsky B, Valenti AJ,
Jernigan JA, Voss A, Tapper M. Public disclosure of
healthcare-associated infections. Infection Control and Hospital
Epidemiology. 26:1-3, 2005.
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