Contact Name: Harold D. Schultz, Ph.D.
Phone Number: (402) 559-7167
e-mail address: hschultz@unmc.edu
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National Institutes of Health, Role of Neuropeptides
in Protection of the Myocardium, 08-01-95/07-31-00, Principal
Investigator.
National Institutes of Health, Cardiac Afferents,
Free Radicals and Ischemia, 08-01-95/07-31-00, Principal Investigator.
American Heart Association, Nebraska Affiliate,
Enhanced Chemoreflex Function in Heart Failure: Role of Central
Angiotensin II, 07-01-97/06-30-00, Principal Investigator.
National Institutes of Health, Cardiopulmonary
Reflexes in Heart Failure, 07-01-87/06-30-02, Co-Investigator.
National Institutes of Health, Cardiovascular
Research Training Program, 07-01-98/06-30-02, Sponsor.
National Institutes of Health, Project III,
Chemoreflex Function in Heart Failure, 07-05-99/06-30-04, Principal
Investigator.
American Heart Association/National, Mechanism of
Impaired cardiac Cheoreflex Function in Diabetes, 01-01-00/12-31-02,
Principal Investigator.
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Schultz, H.D. and E.E. Ustinova. Blockade of
capsaicin receptors abolishes free radical-induced activation of cardiac
afferents in rats. Cardiol. Res. 38:348-355, 1998.
Tran, T.P., K.J. Rhee, H.D. Schultz and M. Carl. Gas
exchange and lung mechanics during percutaneous transtracheal
ventilation in an unparalyzed canine model. Acad. Emerg. Med. 5:320-324,
1998.
Sun, S.Y., W. Wang, I.H. Zucker and H.D. Schultz.
Enhanced peripheral chemoreflex function in conscious rabbits with
pacing-induced heart failure. J. Appl. Physiol. 86:1264-1272, 1999.
Sun, S.Y., W. Wang, I.H. Zucker and H.D. Schultz.
Enhanced activity of carotid body chemorecep-tors in rabbits with heart
failure: role of nitric oxide. J. Appl. Physiol. 86:1273-1282, 1999.
Ma, R., H.D. Schultz and W. Wang. Chronic central
infusion of Ang II potentiates the cardiac sympathetic afferent reflex
in dogs. Am. J. Physiol. Heart and Circ. 277:H15-H22, 1999.
Wang, W., H.D. Schultz and M. Rong. Cardiac
sympathetic afferent sensitivity is enhanced in heart failure. Am. J.
Physiol. Heart and Circ. 277:H812-H817, 1999.
Barrett, C.J. and H.D. Schultz. Sympathoinhibitory
effects of atrial natriuretic peptide in rats with heart failure. J.
Cardiac Failure 5:316-321, 1999.
Schultz, H.D. and S.Y. Sun. Chemoreflex function in
heart failure. Heart Failure Reviews, in press, 2000.
Wang, W., H.D. Schultz and M. Rong. Volume expansion
potentiates cardiac sympathetic afferent reflex in dogs. Am. J. Physiol.
Heart and Circ., in press, 2000.
Ustinova, E.E., C.J. Barrett, S.-Y. Sun and H.D.
Schultz. Oxidative stress impairs cardiac chemo- reflexes in diabetic
rats. Am. J. Physiol. Heart and Circ. 279:H2176-H2187, 2000.
Sun, S.-Y., W. Wang and H.D. Schultz. Activation of
cardiac afferents by arachidonic acid: relative contributions of
metabolic pathways. Am. J. Physiol. Heart and Circ., in press, 2000.
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PREVIOUS
GRADUATE STUDENTS/POST-DOCTORAL FELLOWS (present location):
Elena Ustinova, Ph.D., 1991-1997 - Moved to Texas.
Shu-Yu Sun, M.D., Ph.D., 1996-1999. Instructor,
Department of Physiology & Biophysics, UNMC.
Carolyn Barrett, Ph.D., 1997-1999. Returned to New
Zealand for further postdoctoral work.
Xia-Hong Xia, M.D., Ph.D., 1998-present
Yong-Chun Zeng, M.D., Ph.D., 1999-present.
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Neural and humoral control of cardiovascular and
respiratory function. Apply a broad range of experimental approaches from
molecular to whole animal studies. Emphasis on function of autonomic
reflexes and control of sympathetic outflow and breathing. Experimental
approaches include molecular (gene expression, immunohistochemistry,
transgenic manipulations), cellular (ion channel function, second messenger
systems, Ca++ signaling), organ and integrative studies.
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Neurophysiological measurements in single nerve cells
(patch-clamp) and whole animal; telemetry studies in conscious animals;
molecular and histochemical cores; physiological genomics.
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