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• DEPARTMENT:

Pharmaceutical Sciences

• NAME/TRAINING:

Dong Wang, Assistant Professor
Polymer chemistry/Pharmaceutical chemistry

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ACADEMIC DEGREES:

Peking University 2005 - Ph.D.

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• CONTACT INFORMATION:

Contact Name:	Dong Wang, Ph.D.
Phone Numbers:	(402) 559-1995 Office (402) 559-1323 Lab
e-mail address:	dwang@unmc.edu

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None currently

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• PUBLICATIONS (last 3-5 years):

Wang, D.; Zhang, G.D.; Feng, X.D.; Gu, Z.W.; Yang, J.Y.; Ye, W.P., Copolymerization of L-Lactide with (3S)-3-[(Benzyloxycarbonyl)methyl]morpholine-2,5-dione and Degradation Behavior of the Deprotected Copolymers, Macromol. Chem. Symp., 2001, 14(2), 247. 

Wang, D.; Pechar, M.; Li, W.; Kopečková, P.; Brömme, D.; Kopeček, J., Inhibition of Cathepsin K with Lysosomotropic Macromolecular Inhibitors, Biochemistry, 2002, 41, 8849. 

Wang, D.; Dušek, K.; Kopečková, P.; Dušková-Smrčková, M.; Kopeček, J., Novel Aromatic Azo Containing pH Sensitive Hydrogels: Synthesis and Characterization, Macromolecules, 2002, 35, 7791. 

Wang, D.; Miller, S. C.; Sima, M.; Kopečková, P.; Kopeček, J., Synthesis of Polymeric Bone-Targeting Drug Delivery Systems, Bioconjugate Chemistry, 2003, 14, 853-859. 

Wang, D.; Li, W.; Pechar, M.; Kopečková, P.; Brömme, D.; Kopeček, J., Cathepsin K Inhibitor-Polymer Conjugates: Potential Drugs for the Treatment of Osteoporosis and Rheumatoid Arthritis, International Journal of Pharmaceutics, 2004, 277, 73-79. 

Wang, D.; Miller, S. C.; Sima, M.; Buswell, H.; Parker, D.; Goodrich, K. C.; Kopečková, P.; Kopeček, J., The Study of Arthrotropism of Macromolecules in Adjuvant Induced Arthritis Rat Model---A Preliminary Study, Pharmaceutical Research, 2004, 21, 1741-1749. 

Wang, D.; Miller, S. C.; Kopečková, P.; Kopeček, J., Bone-Targeted Macromolecular Therapeutics, Advanced Drug Delivery Reviews, 2005, 57, 1049-1076. 

Wang, D.; Miller, S. C.; Kopeček, J., Drug Delivery for Musculoskeletal Diseases: Challenges and Opportunities, Advanced Drug Delivery Reviews, 2005, 57, 935-937. 

Miller, S. C.; Wang, D.; Kopečková, P.; Kopeček, J., Biopolymer-based systems for advanced imaging and skeletal tissue-specific therapeutics, Journal of Bone and Mineral Metabolism, 2005, 23(suppl), 103-108.

Wang, D., Brömme, D. Drug Delivery Strategies for Cathepsin Inhibitors in Joint Diseases, Expert Opinion on Drug Delivery. 2005, 2, 1015-1028. 

Chivukular, P.; Dušek, K., Wang, D.; Dušková-Smrčková, M., Kopečková, P.; Kopeček, J, Synthesis and Characterization of Novel Aromatic Azo Bond-Containing pH-Sensitive and Hydrolytically Cleavable IPN Hydrogels, Biomaterial, 2006, 27, 1140–1151.

Pan, H. Z.; Kopečková, P.; Wang, D.; Yang, J. Y.; Miller, S. C.; Kopeček, J, Water-Soluble HPMA Copolymer – Prostaglandin Conjugates Containing a Cathepsin K Sensitive Spacer, J. Drug Targeting, submitted.

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• PREVIOUS GRADUATE STUDENTS/POST-DOCTORAL FELLOWS (present location):

None

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• CURRENT RESEARCH PROJECTS:

New biodegradable water-soluble polymers as drug carrier.

Bone-targeting drug delivery for improved treatment of bone diseases, such as osteoporosis, cancer bone metastasis, osteomyelitis, etc.

Macromolecular therapy for rheumatoid arthritis.

Novel macromolecular imaging agents for non-invasive medical imaging.

Drug delivery systems for orofacial diseases.

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• SPECIALIZED LABORATORY/CLINICAL RESEARCH RESOURCES:

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