For years, an Institutional Animal Care and Use Committee has ensured the proper care of animals at the University of Nebraska Medical Center. By federal mandate, the committee conducts a strict, regulated review of the use of animals in research and teaching. The committee must ensure that researchers comply with the U.S. Public Health Service Policy on Humane Care and Use of Laboratory Animals and all other federal requirements governing animal research. All research projects using animals must be approved by the committee before they are initiated. In this review process, an investigator must clearly explain the project’s purpose and potential value, how the animals will be used, the experience of the research team and whether any alternative research methods are options.