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William Chaney
- Professor, Biochemistry and Molecular Biology and Eppley Institute
Ph.D., Michigan State University, 1979
Phone: (402) 559-6657
Fax: (402) 559-6650
Email: wchaney@unmc.edu
Click here for biographical sketch and publications.
Research in this laboratory is centered on the identification and biological functions of cell-surface molecules.
The role of cell surface carbohydrates in tumorigenesis and metastasis of breast cancer is being studied. The influence of the carbohydrates present at the surface of mouse tumor cell lines on the ability of these tumor cells to undergo metastasis is being investigated using techniques of somatic cell genetics, structural analysis of the oligosaccharides present in these cells, and direct assay of the enzymes responsible for complex carbohydrate biosynthesis.
A second area of interest is in the biochemistry and molecular biology of pancreatic cancer. Using a hamster model of human pancreatic cancer, this laboratory has studied the expression of tumor cell specific cell-surface antigens which react with anti-blood group A antibodies. The glycosyltransferase responsible for blood group A formation, and a membrane glycoprotein which is the acceptor for blood group A modification are induced in pancreatic cancer. The blood group A reactive membrane glycoproteins have been purified, and are being cloned from a cDNA library prepared by this laboratory. Future studies will investigate the distribution and function of these proteins in pancreatic cancer in the hamster model and in humans.
MOST RECENT PUBLICATIONS:
BOOKS:
W. Chaney, E. Haas, and C. Price. Sequence Analysis Guide, second edition, 2007.
R. MacDonald and W. Chaney. USMLE Roadmap Biochemistry, McGraw-Hill, New York, 2007.
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