Department of Biochemistry and Molecular Biology

DavidKlinkebielDavid Klinkebiel

 

 

Assistant Professor, Biochemistry and Molecular Biology

Ph.D., University of Nebraksa-Lincoln, 1990. 

Phone:  (402) 559-3842

Lab: (402) 559-9303

Fax:  (402) 559-6650

 

Email:  dklinkebiel@unmc.edu

 

Click here for further publications.

 

Influence of DNA methylation on gene expression and the association with cancer development.

 

 

RECENT PUBLICATIONS:

 

Yang, J.L., Klinkebiel, D., Boland, M.J., Tang, L., Christman, J.K., 2006.  Promoter methylation and mRNA expression of APC gene in MCF10 breast cancer model. Chinese Journal of Pathology. Zhonghua Bing Li Xue Za Zhi. Jan;35(1):32-6.  Abstract

 

Yang, J.L., Klinkebiel, D., Boland, M.J., Tang, L., Christman, J.K. 2007. Promoter methylation and mRNA expression of WT1 gene in MCF10 breast cancer model. Chinese Journal of Pathology. Zhonghua Bing Li Xue Za Zhi. Apr;36(4):253-8.  Abstract

 

Radhakrishnan, P., Basma, H., Klinkebiel, D., Christman, J., Cheng, P.W. 2008 Cell type-specific activation of the cytomegalovirus promoter by dimethylsulfoxide and 5-Aza-2'-deoxycytidine. Int. J. Biochem. Cell Biol. 40(9)1944-55.  Epub Mar 7 2008.  Abstract

 

Chew YC, West JT, Kratzer SJ, Ilvarsonn AM, Eissenberg JC, Dave BJ, Klinkebiel D, Christman JK, Zempleni J.  Biotinylation of histones represses transposable elements in human and mouse cells and cell lines and in Drosophila melanogaster.  J Nutr. 138(12):2316-22, 2008.  Abstract

 

Iqbal J, Kucuk C, Deleeuw RJ, Srivastava G, Tam W, Geng H, Klinkebiel D, Christman JK, Patel K, Cao K, Shen L, Dybkaer K, Tsui IF, Ali H, Shimizu N, Au WY, Lam WL, Chan WC.  Genomic analyses reveal global functional alterations that promote tumor growth and novel tumor suppressor genes in natural killer-cell malignancies.  Leukemia 2009 Feb 5. [Epub ahead of print]  Abstract