David Klinkebiel

Assistant Professor, Biochemistry and Molecular Biology, and Director, Epigenomics Core Facility

Phone: 402-559-3842 (Office)
402-559-4521 (Lab)
Fax: 402-559-6650
Email: dklinkebiel@unmc.edu

View the Epigenomics Core Facility homepage. 

Education/Training:
Ph.D., University of Nebraska-Lincoln, 1990

Research: 

Research Interest: Influence of DNA methylation on gene expression and the association with cancer development.

Publications: 

Schuh, W.M ., D.L. Klinkebiel, and J.C. Gardner. 1993. Use of an Integrated Transient Flow and Water Budget Procedure to Predict and Partition Components of Local Recharge. Journal of Hydrology. 148:27-60.  

Schuh, W.M., D.L. Klinkebiel, J.C. Gardner, and R.F. Meyer. 1997. Tracer and nitrate movement to groundwater in the Northern Great Plains. Journal of Environmental Quality. 26(5):1335-1347.

Schuh, W.M., and D.L. Klinkebiel. 2003. Effects of Microtopographically Concentrated Recharge on Nitrate Variability in a Confined Aquifer: Model Simulations. Journal of Natural Resources Research. 2(4):257-272.

Schuh, W.M., D.L. Klinkebiel, B.D. Seelig. 2004. Hydraulic Effects of Crop Management Systems on Nitrate Variability In a Confined Aquifer. Journal of Natural Resources Research. 13(1):29-43.

Yang, J.L., Klinkebiel. D., Boland. M.J., Tang. L., Christman. J.K., 2005. Promoter methylation and mRNA expression of MCF10 model cell lines of breast cancer. Chinese Journal of Pathology. Zhonghua Bing Li Xue Za Zhi. March;34(3):177-8.

Yang, J.L., Klinkebiel, D., Boland, M.J., Tang, L., Christman, J.K., 2006. Promoter methylation and mRNA expression of APC gene in MCF10 breast cancer model. Chinese Journal of Pathology. Zhonghua Bing Li Xue Za Zhi. Jan;35(1):32-6. Abstract

Yang, J.L., Klinkebiel, D., Boland, M.J., Tang, L., Christman, J.K. 2007. Promoter methylation and mRNA expression of WT1 gene in MCF10 breast cancer model. Chinese Journal of Pathology. Zhonghua Bing Li Xue Za Zhi. Apr;36(4):253-8. Abstract

Radhakrishnan, P., Basma, H., Klinkebiel, D., Christman, J., Cheng, P.W. 2008 Cell type-specific activation of the cytomegalovirus promoter by dimethylsulfoxide and 5-Aza-2'-deoxycytidine. Int. J. Biochem. Cell Biol. 40(9)1944-55. Abstract

Chew YC, West JT, Kratzer SJ, Ilvarsonn AM, Eissenberg JC, Dave BJ, Klinkebiel D, Christman JK, Zempleni J. Biotinylation of histones represses transposable elements in human and mouse cells and cell lines and in Drosophila melanogaster. J Nutr. 138(12):2316-22, 2008. Abstract

Iqbal J, Kucuk C, Deleeuw RJ, Srivastava G, Tam W, Geng H, Klinkebiel D, Christman JK, Patel K, Cao K, Shen L, Dybkaer K, Tsui IF, Ali H, Shimizu N, Au WY, Lam WL, Chan WC. Genomic analyses reveal global functional alterations that promote tumor growth and novel tumor suppressor genes in natural killer-cell malignancies. Leukemia 23:1139-51. Abstract

Current Funding:

Nebraska Research Initiative - Core Facility Program
Epigenomics Core Facility, UNMC