US Government Principles

CM provides care in accordance with the following:

U. S. Government Principles for the Utilization and Care of Vertebrate Animals Used in Testing, Research and Training:

  1. The transportation, care, and use of animals should be in accordance with the Animal Welfare Act (7 U.S.C.2131 et seq.) and other applicable Federal laws, guidelines and policies.
  2. Procedures involving animals should be designed and performed with due consideration of their relevance to human or animal health, the advancement of knowledge, or the good of society.
  3. The animals selected for a procedure should be of an appropriate species and quality and the minimum number required to obtain valid results. Methods such as mathematical models,computer simulation, and in vitro biological systems should be considered.
  4. Proper use of animals, including the avoidance or minimization of discomfort, distress, and pain when consistent with sound scientific practices, is imperative. Unless the contrary is established, investigators should consider that procedures that cause pain or distress in human beings may cause pain or distress in other animals.
  5. Procedures with animals that may cause more than momentary or slight pain or distress should be performed with appropriate sedation, analgesia, or anesthesia. Surgical or other painful procedures should not be performed on unanesthetized animals paralyzed by chemical agents.
  6. Animals that would otherwise suffer severe or chronic pain or distress that cannot be relieved should be painlessly killed at the end of the procedure or, if appropriate, during the procedure.
  7. The living conditions of animals should be appropriate for their species and contribute to their health and comfort. Normally, the housing, feeding, and care of all animals used for biomedical purposes must be directed by a veterinarian or other scientist trained and experienced in the proper care, handling, and use of the species being maintained or studied. In any case, veterinary care shall be provided as indicated.
  8. Investigators and other personnel shall be appropriately qualified and experienced for conducting procedures on living animals. Adequate arrangements shall be made for their in-service training, including the proper and humane care and use of laboratory animals.
  9. Where exceptions are required in relation to the provisions of these Principles, the decisions should not rest with the investigators directly concerned but should be made, with due regard to Principle II by an appropriate review group such as institutional animal research committee. Such exceptions should not be made solely for the purposes of teaching or demonstration.

All research and testing animal models shall be housed in the facilities of CM and will be cared for by CM personnel. Any exceptions to this policy will only be made when the investigator(s) can provide scientific reasons to justify caring for his/her animals either in the facilities of CM or in other facilities. The CM Director, in consultation with the Vice-Chancellor's office and the IACUC, will make the final determination.

All animal cages and equipment, with few exceptions, are a part of a central institutional pool which is administered, maintained, and serviced by CM for the benefit of all investigators. Conventional or specialized cages and equipment related to animal care purchased from research grant funds become a part of this institutional pool following the termination of the study for which they were obtained. All orders for animal caging and equipment must be authorized by the Director of CM. Uniformity, versatility, efficiency and interchangeability with present or proposed facilities and equipment will be considered when obtaining new equipment. The "Guide", federal legislation and regulations specify the design of caging and space requirements for research animals.