Research Core Facilities

CATEGORIES

Animal Models, Behavior and Physiology
Bioimaging
Cell and Tissue Analysis
Clinical Research

 Data Analysis and Statistics
Genomics
Informatics
Proteomics and Systems Biology


ANIMAL MODELS, BEHAVIIOR AND PHYSIOLOGY

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Resource Services
Mouse Behavior Facility Metabolic Monitoring
Echocardiography Echocardiography
Electron Paramagnetic Resonance Free Radical Measurement
Experimental Irradiation Facility Gamma Irradiation Source
Hemodynamics Hemodynamics

BIOIMAGING		 Back to top
Resource Services
Antibody Labeling Facility (ALF) Radiolabeling
Bioimaging Facility Non-human magnetic imaging and tomography (MRI, CT, SPECT)
Confocal Laser Scanning Microscope Facility Confocal Laser Scanning Microscopy, Live Cell Imaging
PTI-Delta Scan Fluorimeter Real time detection and monitoring of intracellular calcium ion concentrations in living cells.
Electron Microscopy Facility Transmission and Scanning Electron Microscopy
IVIS 200 in vivo Imaging Core Facility IVIS optical imaging
Nanoimaging Atomic Force Microscopy applications 
Nanomaterials Characterization Core Facility Live animal molecular imaging using high-resolution anatomical X-rays.
Virtual Microscopy Digitize Microscopy Images
Ultrasonic Imaging VIVO Ultrasonic Imaging
Radiology Molecular Imaging (PET) Human
MEG Center Magnetoencephalography (MEG) Human
Department of Internal Medicine, Cardiology Cardiovascular Ultrasound

CELL AND TISSUE ANALYSIS		 Back to top
Resource Services
Tissue Sciences Facility Animal Tissue Pathology, Laser Capture Microdissection, specialized histology and immunohistochemistry
Elutiration Core Facility Isolation of monocytes and lymphocytes from peripheral blood mononuclear cells (PBMCs)
Cell Analysis Facility Flow Cytometry Services, Cell Separation
Electron Microscopy Research Facility Electron Microscopy/Confocal Microscopy
Confocal Laser Scanning Microscope Facility Confocal Laser Scanning Microscopy, Live Cell Imaging
Eppley Cancer Center Molecular Biology and HTS Facility  High-throughput chemical, small molecule, and SiRNA (small interfering RNA) screening, High-content cell imaging and analysis, Luminex xMAP technologies
Experimental Irradiation Facility Gamma Irradiation Source
Virtual Microscopy Digitize Microscopy Images

CLINICAL RESEARCH		 Back to top
Resource Services
Center for Collaboration on Research Design and Analysis (CCORDA)              Biostatistics, Research Study Design, Surveys and Analysis
Center for Clinical and Translational Research Resources for Clinical Research
Center for Reducing Health Disparities Consultation on Study Design, Spanish translation services for and promotion and enrollment into research studies
Epigenomics DNA Methylation Analysis
Eppley Cancer Center Protocol Review and Monitoring System Data & Safety Monitoring
Elutriation Core Facility Isolation of monocytes and lymphocytes from peripheral blood mononuclear cells (PBMCs).
Eppley Cancer Center Clinical Trials Office Centralized Protocol and Data Management Unit
Human Genetics Laboratory Cytogenetics, FISH studies, Molecular genetics
Institutional Review Board  (IRB) Assure Protection of all human subjects in research projects on the premises of the UNMC, NMC and UNO
Investigational Pharmacy A source for prescription drugs for research studies
Mutation and Methylation Analysis Facility  Single Nucleotide Polymorphisms (SNPs) and Methylation detection
Next Generation Sequencing Core (NGS) Next Generation Sequencing , Whole genome sequencing
Targeted SNP Analysis SNP (Single Nucleotide Polymorphism) analysis
Tissue Banking Core Facility Tissue for histologic, cytogentic, immunohistochemical, and molecular analysis
REDCap "Do it Yourself" Research Data Base Tool "Do it Yourself" Research Database Tool

DATA ANALYSIS AND STATISTICS		 Back to top
Resource Services
Center for Collaboration on Research Design and Analysis (CCORDA) Biostatistics, Research Study Design Surveys and Analysis

GENOMICS		 Back to top
Resource Services
Cell Analysis Facility Flow Cytometry Services, Cell Separation
Mutation and Methylation Analysis Facility Single Nucleotide Polymorphisms (SNPs), Methylaton  Detection
DNA Microarray Core Facility Affymetrix GeneChip-Whole Transcript Expression, miRNA Analysis, Genome-wide SNP Analysis, Spotted Microarray-Labeling and Hybridizations, Custom Array Printing, Scanning, Image Analysis, Agilent Bioanalyzer - RNA Integrity Analysis, DNA Microarray 
Eppley Cancer Center Molecular Biology and HTS Facility High-throughput chemical, small molecule, and SiRNA (small interfering RNA) screening, High-content cell imaging and analysis, Luminex xMAP technologies
Genetic Sequence Analysis Computational Tools for Genetic Sequence Analysis
High-Throughput DNA Sequencing and Genotyping DNA Sequencing/Genotyping including Next Generation Sequencing
Mouse Genome Engineering Core  DNA Construct, Genotyping, Knockout Animals, Mouse Strain Rederivation, Transgenic Animals, Speed Congenics
Next Generation Sequencing Core (NGS) Next Generation Sequencing, Whole genome sequencing
Human Genetics Laboratory Cytogenetics, FISH studies, Molecular genetics
Epigenomics DNA Methylation Analysis
Targeted SNP Analysis SNP (Single Nucleotide Polymorphism) analysis

INFORMATICS		 Back to top
Resource Services
Center for Bioinformatics and Systems Biology  Discovery, Machine Learning Tools to Solve Biological Problems, Method Development, Data Mining & Knowledge Discovery
Structural Bioinformatics and Molecular Modeling Computational Tools for Studying Structure and Function
 

PROTEOMICS AND SYSTEMS BIOLOGY		 Back to top
Resource Services
Analytical Ultracentrifuge Characterize macromolecular interactions, determine sample purity and native molecular weight, measure equilibirum constants and thermodynamic parameters determine subunit stochiometries, detect and characterize conformation changes.
Structural Bioinformatics & Molecular Modeling Computational Tools for Studying Structure and Function
Mass Spectrometry and Proteomics Mass Spectrometry including MALDI/TOF/TOF, LC-MS/MS such as LTQ Orbitrap, QTRAP and TripleTOF protein identification and quantification. 
Molecular Interactions Core Facility BIACORE is an optical biosensor that uses surface plasmon resonance (SPR) for real-time monitoring of macromolecular interactions without the need for labels.  Affinity measurements, binding kinetics, active concentrations, binding specificity and epitope mapping.  Target-ligand interactions  
Nanomaterials Characterization Core Facility Characterization of supramolecular polymer complexes by AUC.  Polymer characterization by both Static (SLS) and Dynamic (DLS) Light Scattering.
Nuclear Magnetic Resonance Small molecule characterization, Structural determination of peptides, Drug discovery and Tissue analysis.
Protein Structure Facility Amino Acid Analysis, Protein Sequencing, Peptide Separation
Nanoimaging Core Facility Atomic Force Microscopy Applications
Center for Bioinformatics and Systems Biology Discovery, Machine Learning Tools to Solve Biological Problems, Method Development, Data Mining and Knowledge Discovery
Eppley Cancer Center Molecular Biology and HTS Facility High-throughput chemical, small molecule, and SiRNA (small interfering RNA) screening, High-content cell imaging and analysis, Luminex xMAP technologies
The Eppley Structural Biology Facility Protein expression, purification and structure determination at the atomic level with X-Ray Crystallography and Nuclear Magnetic Resonance