Completed Clinical Research | UNMC

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Completed Clinical Research

Clinical trials and studies conducted by our researchers have been funded by both the National Institutes of Health (NIH) and industry. Examples of completed clinical trials and studies that have been conducted by COD faculty are listed below.

National Institute of Dental and Craniofacial Research (NIDCR/NIH) Sponsored Research

Investigator(s)	Research
Wayne B. Kaldahl, DDS	Four Modalities of Periodontal Therapy
Richard A. Reinhardt, DDS, PhD Jeffrey B. Payne, DDS, M Dent Sc	Estrogen and Cytokine Effects on Periodontitis
Jeffrey B. Payne, DDS, M Dent Sc Richard A. Reinhardt, DDS, PhD	Low-Dose Doxycycline Effects on Osteopenic Bone Loss
Richard A. Reinhardt, DDS, PhD	Lymphocyte Subpopulations in Periodontal Tissues
Jeffrey B. Payne, DDS, M Dent Sc	LPS-Monocyte Interactions in Periodontal Disease

Industry/Foundation Funded Research

Investigator(s)	Research
Richard A. Reinhardt, DDS, PhD Caren M. Barnes, RDH, MS Gerald J. Tussing, DDS, MSD	Long Term Open Label Multicenter Phase 3 Trial of the Safety and Efficiency of Minocycline Periodontal Therapeutic System (Minocycline PTS) Adjunctive Use in Patients with Adult Periodontitis
Jeffrey B. Payne, DDS, M Dent Sc Richard A. Reinhardt, DDS, PhD	Effect of Smokeless Tobacco on Inflammatory Mediators
Richard A. Reinhardt, DDS, PhD Thomas M. Petro, PhD	Immune Responses in Type 1 Diabetic Periodontitis
Richard A. Reinhardt, DDS, PhD J. Bruce Bavitz, DMD	Local Anesthetics For Dental Procedures
Jeffrey B. Payne, DDS, M Dent Sc Richard A. Reinhardt, DDS, PhD	Effect of Nonsteroidal Anti-Inflammatory Drugs on Oral Mucosal Lesions
David L. Hoffman, DDS Wayne B. Kaldahl, DDS	The Effects of Periodontal Therapy in Private Practice on Glycosylated Hemoglobin Levels of Diabetic Patients
Caren M. Barnes, RDH, MS Richard A. Reinhardt, DDS, PhD Gwen L. Hlava, RDH, MS Trudy Meinberg, RDH, MS	A Comparison of the Safety and Efficacy of a Highspeed Powered Toothbrush and a Manual Toothbrush Affecting Plaque Accumulation and Gingival Bleeding
Caren M. Barnes, RDH, MS Richard A. Reinhardt, DDS, PhD Gwen L. Hlava, RDH, MS Michelle Sensat, RDH, MS	A Comparison of the Safety and Efficacy of a Powered Toothbrush and a Manual Toothbrush Affecting Plaque Accumulation and Gingival Bleeding
Caren M. Barnes, RDH, MS	Comparison of Four Commercially Available Toothbrushes Comparison of Plaque Removal/Gingivitis Reduction Efficacy of Six Toothbrushes After Three Months of Normal Usage Comparison of the Antiplaque and Antigingivitis Effectiveness and Gingival Abrasiveness of Four Experimental Toothbrushes After Three Months of Normal Usage Comparison of Three Marketed Toothbrushes in Controlling Plaque Accumulation and Gingivitis Severity Following Twelve Weeks Usage Comparison of the Efficacy of an Electromechanical Flossing Device and Manual Flossing in Affecting Interproximal Gingival Bleeding and Plaque Accumulation Comparison of the Efficacy of a Powered Toothbrush in Affecting Plaque Accumulation and Gingival Bleeding
Caren M. Barnes, RDH, MS	Clinical Evaluation of the Prophy-Jet A Clinical Comparison of Piezoelectric and Magnetostrictive Ultrasonic Scalers Effects of an Air-powder Polishing System on Orthodontically Banded and Bracketed Teeth Comparison of Five Commercially Available Disposable Prophylaxis Angles An Evaluation of Disposable Prophylaxis Angles Evaluation of a Plastic Prophylaxis Polishing Cup Compared to a Conventional Natural Latex Prophylaxis Polishing Cup A Clinical Study to Compare the Plaque Removal/Gingivitis Reduction Efficacy of Six Toothbrushes After 3 Months Normal Usage Effect of Frequent Daily Use of Microdent-Containing, Sorbitol Based “Sugar-Free," Breathmints In Reducing Dental Plaque Accumulation One-Time Use Cross-Over Clinical Study to Compare the Cleaning or Plaque Removal Effectiveness of Two Commercial Toothbrushes A Comparative Evaluation of Three Marketed Toothbrushes in Controlling Plaque Accumulation and Gingivitis Severity Passive Immunization Against Streptococcus mutans Mediated Dental Plaque Formation in Humans A Clinical Comparison of the Efficacy of an Electromechanical Flossing Device or Manual Flossing in Affecting Interproximal Gingival Bleeding and Plaque Accumulation A Comparison of the Sensonic Plaque Removal Instrument and A Manual Toothbrush in Affecting Gingivitis and Plaque Accumulation An Evaluation of IPE Mouthrinse to Affect Plaque Prevention and Plaque Reduction A Comparison of the Efficacy of a Rowenta Powered Toothbrush (MH700) and the Oral B Braun Powered Toothbrush in Affecting Plaque Accumulation and Gingival Bleeding
Caren M. Barnes, RDH, MS Richard A. Reinhardt, DDS, PhD Gwen L. Hlava, RDH, MS Michelle Sensat, RDH, MS	A Clinical Evaluation of the Efficacy of a Plastic Prophylaxis Polishing Cup Compared to a Conventional Natural Latex Prophylaxis Polishing Cup The Effects of Aluminum Trihydroxide Airpolishing Powder on Dental Restorative Materials and Enamel A Comparison of a Waterpik Double-Motor Powered Toothbrush and a Manual toothbrush in Affecting Interproximal Bleeding Reduction and Plaque Accumulation An Examination of the Effect of the Sonicare Powered Toothbrush on Salivary Flow on Patients With Xerostomia Secondary to Head and Neck Radiation Therapy A Comparison Of Irrigation To Floss As An Adjunct To Tooth brushing: Effect On Bleeding, Gingivitis and Supragingival Plaque The Effects of NUCare Root Conditioner on Gingival Healing
Caren M. Barnes, RDH, MS Richard A. Reinhardt, DDS, PhD Gwen L. Hlava, RDH, MS Trudy Meinberg, RDH, MS	A Comparison of the Safety and Efficacy of a Rowenta High Speed Powered Toothbrush, the MH700 Powered Toothbrush and a Manual Toothbrush Affecting Plaque Accumulation and Gingival Bleeding
Gordon Mahanna, DDS, MS Caren M. Barnes, RDH, MS	A Randomized, Investigator-Masked, Multicenter Study to Compare the Safety and Efficacy of Nystatin Oral Suspension and Nystatin Frozen Oral Suspension in the Treatment of Patients with Oral Candidiasis A Phase III, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy and Safety of Cevimeline in the Treatment of Xerostomia Secondary to Radiation Therapy for Cancer in the Head and Neck Region
Sponsors of these studies have included: American Academy of Periodontology Foundation Church and Dwight Co., Inc. Daiichi Pharmaceuticals Dentsply Dominic J. Biondi Associates Inc. IBAH, Inc. Juvenile Diabetes Foundation Oral B/Braun PharmaNet, Inc.	Procter and Gamble Rowenta Skyvision, Inc. Smokeless Tobacco Research Council Sunstar Butler Teledyne Water Pik White Hill Oral Technologies Young Dental Mfg., Co.