Clinical Trials

Clinical Trials

Clinical Trials Clinical trials conducted by our researchers have been funded by both NIH and industry. Examples of clinical trials that have been conducted at the Cruzan Center are listed according to the source of support.

National Institute of Dental and Craniofacial Research
(NIH) Sponsored Research:

Investigator(s) Research
Wayne B. Kaldahl, DDS
  • Four Modalities of Periodontal Therapy
Richard A. Reinhardt, DDS, PhD
Jeffrey B. Payne, DDS, M Dent Sc
  • Estrogen and Cytokine Effects on Periodontitis
David L. Hoffman, DDS
Wayne B. Kaldahl, DDS
  • The Effects of Periodontal Therapy in Private Practice on Glycosylated Hemoglobin Levels of Diabetic Patients
Jeffrey B. Payne, DDS, M Dent Sc
Richard A. Reinhardt, DDS, PhD
  • Low-Dose Doxycycline Effects on Osteopenic Bone Loss
Richard A. Reinhardt, DDS, PhD
  • Lymphocyte Subpopulations in Periodontal Tissues

Industry /Foundation Funded Research
Sponsors of these studies include:

  • American Cancer Society
  • Church and Dwight Co., Inc.
  • Daiichi Pharmaceuticals
  • Dentsply
  • Dominic J. Biondi Associates Inc.
  • IBAH, Inc.
  • Oral B/Braun
  • OraPharma
  • Procter and Gamble
  • Smokeless Tobacco Research Council
  • Sunstar Butler
  • Teledyne Water Pik
  • White Hill Oral Technologies
  • Young Dental Mfg., Co.

Investigator(s) Research

Caren M. Barnes, RDH, MS
  • Clinical Evaluation of the Prophy-Jet
  • A Clinical Comparison of Piezoelectric and Magnetostrictive Ultrasonic Scalers
  • Effects of an Air-powder Polishing System on Orthodontically Banded and Bracketed Teeth
  • Comparison of Five Commercially Available Disposable Prophylaxis Angles
  • An Evaluation of Disposable Prophylaxis Angles
  • Evaluation of a Plastic Prophylaxis Polishing Cup Compared to a Conventional Natural Latex Prophylaxis Polishing Cup
  • A Clinical Study to Compare the Plaque Removal/Gingivitis Reduction Efficacy of Six Toothbrushes After 3 Months Normal Usage
  • Effect of Frequent Daily Use of Microdent-Containing, Sorbitol Based “Sugar-Free) , Breathmints In Reducing Dental Plaque Accumulation
  • One-Time Use Cross-Over Clinical Study to Compare the Cleaning or Plaque Removal Effectiveness of Two Commercial Toothbrushes
  • A Comparative Evaluation of Three Marketed Toothbrushes in Controlling Plaque Accumulation and Gingivitis Severity
  • Passive Immunization Against Streptococcus mutans Mediated Dental Plaque Formation in Humans
  • A Clinical Comparison of the Efficacy of an Electromechanical Flossing Device or Manual Flossing in Affecting Interproximal Gingival Bleeding and Plaque Accumulation
  • A Comparison of the Sensonic Plaque Removal Instrument and A Manual Toothbrush in Affecting Gingivitis and Plaque Accumulation
  • An Evaluation of IPE Mouthrinse to Affect Plaque Prevention and Plaque Reduction
  • A Comparison of the Efficacy of a Rowenta Powered Toothbrush (MH700) and the Oral B Braun Powered Toothbrush in Affecting Plaque Accumulation and Gingival Bleeding
Caren M. Barnes, RDH, MS
Richard A. Reinhardt, DDS, PhD
Gwen L. Hlava, RDH, MS
Michelle Sensat, RDH, MS
  • A Clinical Evaluation of the Efficacy of a Plastic Prophylaxis Polishing Cup Compared to a Conventional Natural Latex Prophylaxis Polishing Cup
  • The Effects of Aluminum Trihydroxide Airpolishing Powder on Dental Restorative Materials and Enamel
  • A Comparison of a Waterpik Double-Motor Powered Toothbrush and a Manual toothbrush in Affecting Interproximal Bleeding Reduction and Plaque Accumulation
  • An Examination of the Effect of the Sonicare Powered Toothbrush on Salivary Flow on Patients With Xerostomia Secondary to Head and Neck Radiation Therapy
  • A Comparison Of Irrigation To Floss As An Adjunct To Toothbrushing: Effect On Bleeding, Gingivitis and Supragingival Plaque
  • The Effects of NUCare Root Conditioner on Gingival Healing
Caren M. Barnes, RDH, MS
Richard A. Reinhardt, DDS, PhD
Gwen L. Hlava, RDH, MS
Trudy Meinberg, RDH, MS
  • A Comparison of the Safety Efficacy of a Rowenta High Speed Powered Toothbrush the MH700 Powered Toothbrush and a Manual Toothbrush Affecting Plaque Accumulation and Gingival Bleeding
Gordon Mahanna, DDS, MS
Caren M. Barnes, RDH, MS
  • A Randomized, Investigator-Masked, Multicenter Study to Compare the Safety and Efficacy of Nystatin Oral Suspension and Nystatin Frozen Oral Suspension in the Treatment of Patients with Oral Candidiasis
  • A Phase III, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy and Safety of Cevimeline in the Treatment of Xerostomia Secondary to Radiation Therapy for Cancer in the Head and Neck Region
Richard A. Reinhardt, DDS, PHD
Thomas M. Petro, PhD
  • Immune Responses in Type I Diabetic Periodontitis
Jeffrey B. Payne DDS, M Dent Sc
Richard A. Reinhardt, DDS, PhD
  • Effect of Nonsteroidal Anti-Inflammatory Drugs on Oral Mucosal Lesions


Last modified: November 4, 2008 1:17 PM