Sundaralingam Premaraj, B.D.S., M.S., Ph.D., FRCD(C)

Sundaralingam Premaraj, B.D.S., M.S., Ph.D., FRCD(C)

Dr. PremarajTitle: Associate Professor and Orthodontic Program Director 
Department of Growth & Development
Bioregulation Group
University Dental Associates

Address 
Room: 2436
UNMC College of Dentistry
40th & Holdrege Streets
Lincoln, NE  68583-0740

Telephone: (402) 472-4970
Fax: (402) 472-5290
email:

Education:

  • BDS (Hons), University of Peradeniya, Sri Lanka
  • MS (Orthodontics), Postgraduate Institute of Medicine, University of Colombo, Sri Lanka
  • Certificate in Orthodontics, Ohio State University, Columbus, Ohio
  • PhD, Oral Biology, Ohio State University, Columbus, Ohio,
  • Diplomate, American Board of Orthodontics
  • Fellow of the Royal College of Dentists of Canada – FRCD(C)

Teaching Responsibilities:

  • ORT 638 Clinical Orthodontics I: Course Director
  • ORT 676 Clinical Orthodontics II: Course Director
  • PG 849 Biophysical principles I: Course Director
  • PG 850 Biophysical principles II: Course Director
  • PG 844 Cephalometrics: Course Director
  • Postgraduate Principles of Mechanics/Orthodontic Technique: Course Director
  • Dentofacial Program: Instructor
  • Ortho-Perio Interdisciplinary Seminar: Instructor
  • Critical Review of Current Literature: Instructor
  • Clinical Orthodontic Seminars: Instructor
  • Dentofacial Clinical Conference: Instructor
  • Ortho-Endo Graduate Student Seminar: Instructor

Research Interests:

  • Cranial Suture Biology
  • Tgf-β3 Cell Signaling in Osteoblasts
  • Molecular Biology of Tooth Movement

Grants:

  • Shift in Species Composition of Supra and Subgingival Gingival Microbiome as a Risk Factor In Dental Caries/Periodontal Disease: A Comparative Study with Braces/Invisalign Treatment. Align Technology, Inc.,  July 2013, Co-Investigator: Sundaralingam Premaraj, PI: Thyagaseely Premaraj
  • Role of PTHrp in Orthodontic Tooth Movement. American Association of Orthodontists Foundation, July 2012, PI: Sundaralingam Premaraj.
  • Shift in Species Composition of Supra and Subgingival Gingival Microbiome as a Risk Factor in Dental Caries/Periodontal Disease: A Comparative Study with Braces/Invisalign Treatment., Align Technology, July 2012, Co-Investigator: Sundaralingam Premaraj, PI: Thyagaseely Premaraj.

Recent Publications:

  • Premaraj T, Simet S, Beatty M, Premaraj S, Oral Epithelial Cell reaction following exposure to Invisalign® plastic Material, American Journal of Orthodontics and Dentofacial Orthopedics, January 2014, accepted for publication, In Press.
  • Premaraj S, Souza I, Premaraj T, Focal Adhesion Kinase Mediates β-Catenin Signaling in Periodontal Ligament Cells, Biochemical and Biophysical Research Communications, 2013 439(4): 487-452
  • Premaraj S, Moursi A., Delivery of Transforming Growth Factor-Beta 3 Plasmid in a Collagen Gel Inhibits Cranial Suture Fusion in Rats, The Cleft Palate-Craniofacial Journal, 2013 50(3):e47-60
  • Premaraj, S., I. Souza, T. Premaraj. Mechanical loading activates beta-catenin signaling in periodontal ligament cells, The Angle Orthodontist, 2011 81(4) 592-9.
  • Premaraj, S., Mundy, B., Morgan, D., Winnard, P.L., Moone,y M.P., Moursi, A.M. Sustained delivery of bioactive cytokine using a dense collagen gel vehicle. Archives of Oral Biology, 2006 51(4):325- 33. 
  • Premaraj, S., B. Mundy, J. Parker-Barnes, P. L. Winnard and A. M. Moursi. Collagen Gel Delivery of Tgf-beta3 gene in Rat osteoblast and Calvarial culture. Orthodontics and Craniofacial Research, 2005 8(4): 320-2.

Abstracts:

  • A. Meyer, S. Premaraj, M. Beatty and T. Premaraj. Oral Epithelial Cell Response to Orthodontic Plastic - Preliminary Report, J Dent Res., 91 (Spec Iss B): 366, 2012
  • K. Russell, T. Premaraj, and S. Premaraj. Expression of Chemokines in Periodontal Tissues during Orthodontic Tooth Movement, J Dent Res., 91 (Spec Iss B): 641, 2012
  • S. Premaraj, F. Chau and T. Premaraj. Tooth Extraction/Hypofunction-Induced Changes in Alveolar Osteocyte Expression of SOST/Sclerostin, J Dent Res., 91 (Spec Iss B): 1617, 2012
  • S. Premaraj, I. Souza, T. Premaraj. Molecular mechanisms of orthodontic tooth movement: emerging concepts, Eur J Orthod, e42, 2011
  • S. Premaraj, I. Souza, T. Premaraj. Nitric Oxide Mediates Mechanical loading-induced beta-catenin signaling in PDL cells, J Dent Res., 90 (Spec Iss A): 1527, 2011
  • C. Parks, J. Shin, T. Premaraj, S. Premaraj. FAK Regulates Activation of Beta-Catenin Signaling in Compressed PDL Cells, J Dent Res., 90 (Spec Iss A): 3651, 2011
  • L. Petersen, J. Shin, T. Premaraj, S. Premaraj. PGE2 mediates mechanical loading-induced up-regulation of Cx43 in PDL cells, J Dent Res., 90 (Spec Iss A): 3646, 2011
  • J. Stengle,  L. Talluri, I. Souza, T. Premaraj, and S. Premaraj. Prostaglandin E2 Activates Beta-Catenin Signaling In Periodontal Ligament (PDL) Cells, J Dent Res., 89 (Spec Iss B): 3748, 2010.
  • S. Premaraj, I. Souza, M. Talluri, M. Guerrero, J. Barta, T. Premaraj.  Mechanical strain activates beta-catenin signaling in periodontal ligament cells, J. Dent. Res 89 (Spec Iss A), 2010.
  • S. Jayappa, J. Thoendel, A. Moursi, S. Premaraj. Transforming growth factor-beta3 induced apoptosis of osteoblasts, J Dent Res 87 (Spec Iss B), 2008.
  • B. McIntyre, J. Thoendel, A. Moursi, S. Premaraj. Effects of Transforming growth factor-beta3 on proliferation and differentiation of MC3T3-E1 cells, J Dent Res 87 (Spec Iss B), 2008.
  • S. Premaraj, B. Mundy, M. Mooney and A. M. Moursi. Inhibition of Rat Cranial Suture Fusion with Plasmid Encoding Tgf-beta3, J Dent Res 85 (Spec Iss A):(1223), 2006.
  • A.M. Mercado, K. Lubitz, J. Halderman, S. Premaraj, M. Beck, P. Larsen, and K. Vig. Root Development and Bone grafting in Patients with Alveolar Clefts, J Dent Res 85 (Spec Iss A):(0124), 2006.
  • J. Halderman, K. Lubitz, S. Premaraj, F.M. Beck, A.M. Mercado, P. Larsen, and K.W.L. Vig. Canine Eruption and Secondary Alveolar Bone Grafting in UCLP Patients, Journal of Dental Research 84 (Spec Iss A):3690, 2005.
  • K. Lubitz, J. Halderman, S. Premaraj, F.M. Beck, A.M. Mercado, P. Larsen, and K.W.L. Vig. Canine Root Development and Alveolar Bone Grafting in UCLP Patients, Journal of Dental Research 84 (Spec Iss A) 2005.
  • Effects of doxorubicin hydrochloride in the rat mandibular condyle Wada Akira, Hasebe Osamu, Sugiura Iwane, Itou Kouzi, Kubo Katsutoshi, Sundaralingam Premaraj, Maeda Akihiko, Kameyama Yoichiro. Japanese Journal of Oral Science, 47 (5): 594-595, 1998.
  • Fuwa Y, Goto S, Hayakawa S, Premaraj S, Negoro T. Application of Biofeedback Technique using Tongue Training Plate. Orthodontic Products 4(6): 62-65, 1998.

 

Research Communications:

  • Oral Epithelial Cell Response to Orthodontic Plastic - Preliminary Report, C. Hopke, S. Premaraj, T. Premaraj. Poster presented at the Annual meeting of AAO, May 5-8, 2012, Honolulu, HI.
  • Molecular mechanisms of Tooth movement: Emerging concepts, S. Premaraj, I. Souza, T. Premaraj. Paper presented at the 87th Congress of the European Orthodontic Society, June 19-
    23, 2011, Istanbul, Turkey.
  • FAK Regulates Activation of Beta-Catenin Signaling in Compressed PDL Cells, C. Parks, J. Shin, T. Premaraj, S. Premaraj. Poster presented at the 64th Annual session of the American Academy of Pediatric dentistry, May 26-29, 2011, New York City, NY.
  • Role of Sclerostin in Tooth Extraction-Induced Alveolar Bone Resorption, F. Chau and S. Premaraj. Abstract presented at the Annual meeting of AAO, May 14-17, 2011, Chicago, IL
  • Mechanical strain, PGE2 and Beta-Catenin signaling interactions in Periodontal Ligament Cells, T. Premaraj, L. Talluri, I. Souza, M. Stengle, S. Premaraj. Abstract presented at the Annual meeting of AAO, May 1 – 4, 2010, Washington, DC.
  • Effects of Transforming growth factor-beta3 on osteoblast apoptosis, proliferation and differentiation, S. Jayappa, B. McIntyre, J. Thoendel, A. Moursi, S. Premaraj. Abstract presented, 149th Annual meeting of ADA, October 16-19, 2008, San Antonio, TX.
  • S. Jayappa, J. Thoendel, A. Moursi, S. Premaraj. Transforming growth factor-beta3 induced apoptosis of osteoblasts. Abstract presented, 86th General sessions of IADR, July 2-5, 2008, Toronto, Canada.
  • B. McIntyre, J. Thoendel, A. Moursi, S. Premaraj. Effects of Transforming growth factor-beta3 on proliferation and differentiation of MC3T3-E1 cells, Abstract presented, 86th General sessions of IADR, July 2-5, 2008, Toronto, Canada.
  • S. Swenson, J. Brand, S. Harn and S. Premaraj. Accuracy of Dolphin 3D cephalometric analysis using CBCT vs. Traditional radiography, Abstract presented at 108th Annual Session of American Association of Orthodontists (AAO), May 16-20, 2008, Denver, CO.
  • Apoptosis regulation in TGF-beta3 gene therapy mediated cranial suture patency, S. Premaraj, B. Mundy, M. Mooney, A.M. Moursi. Paper presented at the 64th Annual meeting of American Cleft Palate-Craniofacial Association, April 23-28, 2007 Broomfield, Colorado.
  • Delivery of Transforming Growth Factor-Beta 3 Plasmid in a Collagen Gel Vehicle Delays Fusion of the Rat Posterior Frontal Suture in Vivo. S. Premaraj, B. Mundy, M. Mooney, A.M. Moursi. Abstract presented at the 63rd Annual Meeting of the American Cleft Palate-Craniofacial Association April 3-8, 2006, Vancouver, BC, Canada.
  • Canine Root Development and Outcome of Alveolar Bone Grafting In Patients with Unilateral Cleft Lip and Palate. Ana Mercado, Kathryn Lubitz, Josh Halderman, Sundaralingam Premaraj, Michael Beck, Peter Larsen, Katherine Vig. Abstract presented at the 63rd Annual Meeting of the American Cleft Palate-Craniofacial Association April 3-8, 2006, Vancouver, BC, Canada.
  • Inhibition of Rat Cranial Suture Fusion with Plasmid Encoding Tgf-beta3.  S. Premaraj, B. Mundy, M. Mooney and A. M. Moursi. J Dent Res 85 (Spec Iss A):(1223), 2006
  • Root Development and Bone grafting in Patients with Alveolar Clefts.  A.M. Mercado, K. Lubitz, J. Halderman, S. Premaraj, M. Beck, P. Larsen, and K. Vig. J Dent Res 85 (Spec Iss A) :(0124), 2006
  • Non-Viral Delivery and Subsequent Expression of Plasmid-Encoded Tgf-Beta3 via Collagen Gel in Osteoblast and Calvarial Culture S. Premaraj, B.L. Mundy, M.P. Mooney, A.M. Moursi. Presented at the 62nd Annual meeting of American Cleft palate and craniofacial association, April 4-9, 2005, Myrtle Beach, South Carolina, USA.
  • Canine Eruption and Secondary Alveolar Bone Grafting in UCLP Patients J. Halderman, K. Lubitz, S. Premaraj, F.M. Beck, A.M. Mercado, P. Larsen, and K.W.L. Vig. Journal of Dental Research 84 (Spec Iss A): 3690, 2005.
  • Canine Root Development and Alveolar Bone Grafting in UCLP Patients K. Lubitz, J. Halderman, S. Premaraj, F.M. Beck, A.M. Mercado, P. Larsen, and K.W.L. Vig. Journal of Dental Research 84 (Spec Iss A): 2005
  • Collagen Gel Delivery of Tgf-beta 3 Gene in Rat Osteoblast and Calvarial Culture S. Premaraj, B. Mundy, J. Parker-Barnes, P.L. Winnard, A.M. Moursi. Conference on Orthodontic Advances in Science and Technology (COAST), 2nd Biennial Conference, August 27-30, 2004.  Pacific Grove, California, USA
  • Delivery of TGF-beta 3 plasmid DNA via collagen gel in rat Calvarial osteoblast culture M. Moursi, S. Premaraj, J. Parker-Barnes, P. L. Winnard. 31st European Symposium on Calcified tissues, 5-9 June 2004. Nice, France.
  • Collagen gel delivery of TGF beta-3 gene in Calvarial osteoblast S. Premaraj, J. Parker-Barnes, P.L. Winnard, and A.M. Moursi. Journal of Dental Research 83 (Spec Iss A): 17, 2004
  • Evaluation of secondary alveolar bone grafting using a modified Bergland scale S. Premaraj, F.M. Beck, P. Larsen, and K.W.L. Vig. Annual meeting of American Cleft palate and craniofacial association, May 2002, Seattle, Washington, USA.
  • Outcome of secondary alveolar bone grafting in cleft lip and palate patients. S. Premaraj, F.M. Beck, P. Larsen, and K.W.L. Vig. Journal of Dental Research 80(Spec Iss A): 2949, 2002
  • Effects of Cyclosporine-A on the alveolar bone in rats. S. Premaraj, H. Tanaka, S. Konishi, K. Kubo, H. Maeda, S. Goto and Y. Kameyama .Journal of Dental Research 77(IADR abstracts): 1999.
  • Effects of 5-Fluorouracil on the mandibular condyle of the rats. Y. Suzumura, E. Sato, S. Premaraj, H. Maeda, and Y. Kameyama. 40th Annual Sessions of the Japanese Association of Oral Biology, Nagoya, Japan. October 1998.
  • H. Tanaka, S. Premaraj, J. Muramatsu, Y. Tsujikoka, H. Maeda and Y. Kameyama. Periodontal tissues of the growing Vitamin C deficient Rats. Journal of Dental Research 77(IADR abstracts): 975, 1998.

 

 

 

 

     

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