Richard A. Reinhardt, D.D.S., Ph.D.

Richard A. Reinhardt, D.D.S., Ph.D.

Title: Professor, Co-Director Undergraduate Periodontics, BJ & Ann Moran Professor of Periodontology
Surgical Specialties Department
Bioregulation Group

Address
Room: 2170A
UNMC College of Dentistry
40th and Holdrege
Box 830740
Lincoln, NE 68583-0740

Telephone: (402) 472-1287
Fax: (402) 472-5290
email: rareinha@unmc.edu

Education:

• D.D.S. University of Nebraska, Lincoln, Nebraska
• M.S. University of Nebraska, Lincoln, Nebraska
• Ph.D. University of Nebraska Graduate College, Omaha, Nebraska

Teaching Responsibilities:

• Director PERIO 553 Periodontal Therapy
• Co-Director PERIO 629/630 Clinical Periodontics II
• Co-Director PERIO 696 Clinical Periodontics III
• Director PERIO 977M Prosthodontic & Periodontal Interrelationships
• Director PERIO 871 Advanced Periodontology

Research Interests:

• Immunoregulation of periodontal disease and bone metabolism (cell culture and in vivo)
• Effectiveness of periodontal therapy

Grants:

• July 2008 to June 2009 Pharmaco-manipulation of Statin-induced Bone. Surgical Specialties Postgraduate Research Fund: Reinhardt, R.A., Killeen, A., $7,500.
• July 2007 to July 2008 Pharmacol-manipulation of Statin-induced Bone. Surgical Specialties Postgraduate Research Fund and College of Dentistry Seed Grant: Reinhardt, R.A., Rutledge, J., $12,500.
• June 2006 to December 2006 Use of Anabolic Agents Complexed with β-CD-Alen for Improved Stimulation of Local Bone Growth in the Oral Cavity. UNeMed Technology Advisory Group: Wang, D., Reinhardt, R.A., $10,000.
• July 2005 to June 2007 Effect of Topically-Applied Simvastatin on Alveolar Bone Growth in Dogs. University of Nebraska Medical Center College of Dentistry Research Grant: Reinhardt, R.A., Morris, M., $5,000.
• October 2004 to October 2005 Efficacy of Oral Hygiene Regimens. Effect on Supragingival Plaque, Gingivitis, Bleeding and Subgingival Microbial Counts. Waterpik Technologies, Inc: Barnes, C.M., Reinhardt, R.A., Payne, J.B, $78,045.

Recent Publications:

• Mikuls, T.R., Payne, J.B., Reinhardt, R.A., Thiele, G.M., Maziarz, E., Cannella, A.C., Holers, V.M., K uhn, K.A., O'Dell, J.R. Antibody responses to Porphyromonas ginvivalis (P. gingivalis) in subjects with rheumatoid arthritis and periodontitis. Int Immunopharmacol 9:38-42, 2009.
• Golub, L.M., Lee, H.M., Stoner, J.A., Sorsa, T., Reinhardt, R.A., Wolff, M.S., Ryan, M.E., Nummikoski, P.V., Payne, J.B. Subantimicrobial-dose doxycycline modulates gingival crevicular fluid biomarkers of periodontitis in postmenopausal osteopenic women. J Periodontology 79:1409-1418,2008.
• Al-Salleeh, F., Beatty, M.W., Reinhardt, R.A., Petro, T.M., Crouch, L. Human Osteogenic Protein-1 Induces Osteogenic Differentiation of Adipose-derived Stem Cells Harvested From Mice. Archs Oral Biol 53:928-936,2008.
• Morris, M., Lee, Y., Lavin, M.T., Giannini, P.J., Schmid, M.J., Marx, D.B., Reinhardt, R.A. Injectable Simvastatin in Periodontal Defects and Alveolar Ridges: Pilot Studies. J Periodontology 79:1465-1473,2008.
• Liu, X.M., Wiswall, A.T., Rutledge, J.E., Akhter, M.P., Cullen, D.M., Reinhardt, R.A., Wang, D. Osteotropic Beta-cyclodextrin for Local Bone Regeneration. Biomaterials 29:1686-92, 2008.
• Lee, Y., Schmid, M.J., Marx, D.B., Beatty, M.W., Cullen, D.M., Collins, M.E., Reinhardt, R.A. The Effect of Local Simvastatin Delivery Strategies on Mandibular Bone Formation In Vivo. Biomaterials 29:1940-9, 2008.
• Bradley, J.D., Cleverly, D.G., Burns, A.M., Helm, N.B., Schmid, M.J., Marx, D.B., Cullen, D.M., Reinhardt, R.A. Cyclooxygenase-2 Inhibitor Reduces Simvastatin-induced Bone Morphogenetic Protein-2 and Bone Formation In Vivo. J Periodontal Res 43:267 73, 2007.
• Walker, C., Puumala, S., Golub, L.M., Stoner, J.A., Reinhardt, R.A., Lee, H.M., Payne, J.B. Subantimicrobial Dose Doxycycline Effects on Osteopenic Bone Loss: Microbiologic Results. J Periodontology 78:1590-1601, 2007.
• Liu, X.M., Lee, H.T., Reinhardt, R.A., Marky, L.A., Wang, D. Novel Biomineral-binding Cyclodextrins for Controlled Drug Delivery in the Oral Cavity. J Control Release 11;122:54-62, 2007.
• Reinhardt, R.A., Stoner, J.A., Golub, L.M., Wolff, M.S., Lee, H.M., Meinberg, T.A., Lynch, J.C., Ryan, M.E., Sorsa, T., Payne, J.B. Efficacy of Sub-antimicrobial Dose Doxycycline in Post-menopausal Women: Clinical Outcomes. J Clin Periodontology 34:768-775, 2007.
• Payne, J.B., Stoner, J.A., Nummikoski, P.V., Reinhardt, R.A., Goren, A.D., Wolff, M.S., Lee, H.M., Lynch, J.C., Valente, R., Golub, L.M. Subantimicrobial Dose Doxycycline Effects on Alveolar Bone Loss in Post-Menopausal Women. J Clin Periodontology 34:776-787, 2007.
• Preston, R.D., Meinberg, T.A., Payne, J.B., Schmid, M.J., Lee, H.M., Golub, L.M., Marx, D.B., Reinhardt, R.A. Inflammatory Mediator Release Following Bone Grafting in Humans: A Pilot Study. J Clin Periodontology34:797-804, 2007.
• Liu, X.M., Reinhardt, R.A., Wang, D. Drug Delivery Strategies for Common Orofacial Diseases. J Drug Target 14:583-597, 2006.
• Golub, L.M., Payne J.B., Reinhardt, R.A., Nieman, G. Can Systemic Disease Co-induce (Not Just Exacerbate) Periodontitis? A Hypothetical "two hit" Model. J Dent Res 85:102-105, 2006.

Abstracts:

• Reinhardt, R.A., Stoner, J.A., Golub, L.M., Lee, H.M., Payne J.B. GCF MMP-8 in postmenopausal women. Association with progressive attachment loss. J Dent Res 88 (Spec. Is):Abstract 2917, 2009.
• Reinhardt, R.A., Stoner, J.A., Golub, L.M., Lee, H.M., Payne, J.B. Longitudinal GCF biomarkers associated with ongoing clinician attachment loss. Abstract #1006, 2008 American Academy of Periodontology Annual Session.
• Chamberlain, J.M., Schieber, M.P., Byarlay, M.R., Giannini, P.J., Killeen, A.C., Marx, D.B., Reinhardt, R.A. Effect of simvastatin on guided bone regeneration. Abstract #789, 2008 JADR.
• Mikuls, T.R., Payne, J.B., Reinhardt, R.A., Thiele, G.M., Maziarz, E., Cannella, A.C., Holers, V.M. Kuhn, K.A., Bergman, D.A., O'Dell, J.R. Immunity to the oral pathogen, Porphyromonas gingivalis (P. givgivalis) in subjects with rheumatoid arthritis and periodontitis. Arthritis Rheum 58(suppl), s274, 2008.
• Payne, J.B., Stoner, J.A., Lee, H.M., Nummikoski, P.V., Reinhardt, R.A., Valente, R., Golub, L.M. Serum bone-resorption biomarkers: correlation with alveolar and systemic bone changes. J Dent Res 87 (Spec. Is.): Abstract 1558, 2008.
• Golub, L.M., Lee, H.M., Stoner, J.A., Reinhardt, R.A., Sorsa, T., Goren, A.D., Payne, J.B. Bone-turnover markers in postmenopausal osteopenic women with periodontitis (POWP): Subantimicrobial-dose doxycycline (SDD). J Dent Res 87 (Spec. Is.): Abstract 3491, 2008.
• Reinhardt, R.A., Stoner, J.A., Lee, H.M., Nummikoski, P.V., Golub, L.M., Payne, J.B. Crevicular fluid resorption marker: correlations with alveolar and systemic bone changes. J Dent Res 87 (Spec. Is.): Abstract 2909, 2008.

Service Activities:

• Consultant, Veterans Administration Medical Center, Lincoln, NE
• American Board of Dental Examiners, Periodontal Task Force
• American Board of Dental Examiners Calibration Committee