|
| ||||||||||||||||||||||||||||||||||||||||||||
![]() |
|
| Home >> Research >> Bioregulation Group | |
|
Understanding and manipulating immune responses, inflammation, and bone turnover will lead to more effective treatment of numerous conditions, including infectious diseases, chronic inflammatory diseases (arthritis and periodontitis), autoimmune diseases (multiple sclerosis and insulin-dependent diabetes), metabolic bone diseases (osteoporosis), malocclusions, abnormal craniofacial development and cancer. Secreted cytokines and cell surface receptors regulate the immune system, bone-turnover and tissue repair. It is, therefore, critical to identify these cytokines and their receptors, as well as their genes, promoter sequences, and associated transcription factors. Discovery of novel cytokines, synthetic analogues, or blocking agents that improve the course of the inflammatory, immune and bone responses will be more predictable using this information. Human model protocols used by the Bioregulation Group (BRG) in these endeavors are of three main types:
Rodent model protocols used include:
Last modified: April 2, 2007 6:14 PM
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
Copyright © 2007 University of Nebraska Medical Center, College of Dentistry. Send questions or comments regarding the College of Dentistry website to: WebComments, Last modified: March 9, 2007. |
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| |