Nebraska Center for Cellular Signaling

The Nebraska Center for Cellular Signaling (NCCS) was formed in the fall of 2003 by Dr. Margaret Wheelock to create a Center of Biomedical Research Excellence (CoBRE) under the IDeA program, which is funded primarily by the National Institutes of Health (NIH) and the National Institute of General Medical Sciences. This Center, through the collaborations of the University of Nebraska Medical Center, Creighton School of Medicine, and the University of Nebraska-Lincoln, fosters new research initiatives dedicated to improving the oral and dental health of Nebraskans and citizens of other states. Junior and established researchers at these institutions conduct innovative and collaborative research efforts supported by the Center. This Center presents a strong mentoring environment to attract and promote the development of promising investigators.

Focus

A number of areas within the field of cell biology are rapidly converging on a common theme: cellular signal transduction. This is particularly true for the fields of cell adhesion, cell motility and cancer biology. The main focus of this Center is to bring together individuals studying signal transduction to form an organized, cohesive group that will provide leadership and mentoring to junior faculty interested in signaling.

Current Research Projects

The Mechanism of Aberrant DNA Methylation in Mouse Lymphomagenesis
Rene Opavsky, Ph.D., assistant professor, Eppley Institute, UNMC

The Functions and Regulatory Mechanisms of a Specific Protein Phosphatase 1 Complex in the DNA Damage Response and Cancer Progression
Aimin Peng, Ph.D., assistant professor, Oral Biology, UNMC

Live Cell Microscopy Core

The Live Cell microscope located at the College of Dentistry in Lincoln provides a humidity- and CO2 -controlled growth chamber and Intelligent Imaging Innovations software for collecting images. This system includes digital de-convolution, 3D rendering and lasers for FRAP analysis of protein turnover. This microscope is available for use by investigators at UNL or the COD. A second Live Cell microscope is housed in the Eppley Institute. This instrumentation is available to investigators in Omaha (UNMC and Creighton), and provides a humidity- and CO2 -controlled growth chamber and Intelligent Imaging Innovations software for collecting images, spinning disc confocal, digital de-convolution, 3D rendering and lasers for FRAP analysis of protein turnover. For more information or to schedule imaging, please contact the director: Jim Wahl, Ph.D. at 402-472-1324 or jwahl@unmc.edu.

External Advisory Board

Thomas Carey, Ph.D., University of Michigan
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Jean Schwarzbauer, Ph.D., Princeton University
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George Prendergast, Ph.D. Lankenau Institute for Medical Research (LIMR)
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