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The Nebraska Center for Cellular Signaling (NCCS) was formed in the fall of 2003 creating a Center of Biomedical Research Excellent (CoBRE) under the IdeA program, which is funded by the National Institutes of Health and the National Center for Research Resources. This Center, through the collaborations of the University of Nebraska Medical Center, Creighton School of Medicine, and the University of Nebraska-Lincoln, will be the focal point for fostering new research initiatives dedicated to improving the oral and dental health of Nebraskans and citizens of other states. Junior and established researchers at these institutions conduct innovative and collaborative research efforts supported by the Center. This Center presents a strong mentoring environment to attract and promote the development of promising investigators.
Focus
A number of areas within the field of cell biology are rapidly converging on a common theme:
cellular signal transduction. This is particularly true for the fields of cell adhesion, cell motility and cancer biology. The main focus of this Center is to bring together individuals studying signal transduction to form an organized, cohesive group that will provide leadership and mentoring to junior faculty interested in signaling.
Growing our Own article Research
The project leaders of this Center share interests in cell motility, cell adhesion, growth regulation, apoptosis, metastasis, and invasion. A thread that ties this group together is their desire to understand signaling pathways that impact cellular behavior as well as the underlying theme of signaling through adhesion receptors and receptor tyrosine kinases.
Live Cell Microscopy Core
The Live Cell microscope located at the College of Dentistry in Lincoln provides a humidity- and CO2-controlled growth chamber and Intelligent Imaging Innovations software for collecting images. This system includes digital de-convolution, 3D rendering and lasers for FRAP analysis of protein turnover. This microscope is available for use by investigators at UNL or the COD.
A second Live Cell microscope is housed in the Eppley Institute. This instrumentation is available to investigators in Omaha (UNMC and Creighton), and provides a humidity- and CO2-controlled growth chamber and Intelligent Imaging Innovations software for collecting images, spinning disc confocal, digital de-convolution, 3D rendering, lasers for FRAP analysis of protein turnover, and lasers for FRET.
External Advisory Board
Thomas Carey, Ph.D., University of Michigan
web link
Jean Schwarzbauer, Ph.D., Princeton University
web link
Contact Information:
Valeta S. Creason - Wahl
Program Coordinator
UNMC LTC 12726B
987696 UNMC
Omaha, NE 68198-7696
402-559-4682
402-559-3888 FAX
email:
vcreason@unmc.edu
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Related Links
National Institutes of Health
National Center for Research Resources (NCRR)
Content of this page designed and maintained by Valeta Creason Wahl
