Thyagaseely (Sheela) Premaraj, BDS, PhD

Thyagaseely (Sheela) Premaraj, BDS, PhD

Dr. Sheela PremarajTitle: Assistant Professor
Department of Growth & Development
Orthodontic Section
University Dental Associates

Address
Room: 2431
UNMC College of Dentistry
40th and Holdrege
Box 830740
Lincoln, NE 68583-0740

Telephone: (402) 472-1118
Fax: (402) 472-5290
email:

Education

  • BDS (Hons), University of Peradeniya, Sri Lanka
  • PhD, Anaerobic Bacteriology, Institute of Anaerobic Bacteriology, Gifu University School of Medicine, Gifu University, Japan
  • Certificate in Orthodontics, University of Nebraska Medical Center College of Dentistry

Teaching Responsibilities

  • ORT 576 Orthodontic Concept 1, Course Director
  • ORT 588 Orthodontic Concepts II, Course Director
  •  ORT 590 Orthodontic Technique, Course Director
  • OBIO 849, Biophysical principles, Instructor
  • OBIO 850, Biophysical principles, Instructor
  • OBIG 840, Cranio facial Growth and Development- Director
  •  PG Principles of Mechanics, Instructor
  •  PG Cephalometrics, Instructor
  • Postgraduate program research projects, Director
  • Critical Review of Current Literature, Instructor
  • Clinical Orthodontic Seminars, Instructor

 

Research Interests

  • Anaerobic Bacteriology
  • Molecular Microbiology, Oral Microbes
  • Mechanical Loading Responses to Periodontal Ligament Cells

Publications

  • T. Premaraj, S. Simet, M. Beatty and S. Premaraj, "Oral Epithelial Cell Reaction Following Exposure to Invisalign® Plastic," Submitted to American Journal of Orthodontics and Dentofacial Orthopedics, January 2014, accepted for publication, in press
  • S. Premaraj, I. Souza and T. Premaraj, "Focal Adhesion Kinase Mediates β-Catenin Signaling in Periodontal Ligament Cells," Biochemical and Biophysical Research Communications, 2013 439(4): 487-452
  • Raheleh Miralami, Laura Koepsell, Thyagaseely Premaraj, Bongok Kim, Geoffrey M. Thiele, J. Graham Sharp, Kevin L. Garvin and Fereydoon Namavar, "Comparing Biocompatibility of Nanocrystalline Titanium and Titanium-Oxide with Microcrystalline Titanium," MRS Proceedings, 1569, mrss13-1569-nn15-22 doi:10.1557/opl. 2013.804.
  • S. Premaraj, I. Souza and T. Premaraj,  "Mechanical Loading Activates Beta-catenin Signaling in Periodontal Ligament Cells," The Angle Orthodontist, 2011 81(4) 592-9
  • Q. Xia, Z. Yu, T. Premaraj, T. Williams and M. Morrison, "Real Time PCR and PCR-DGGE Analyses of Stool Microbiomes from Infants Fed Human Breast Milk, Infant Formula, or Formula with Added Fructo-oligosaccharides," Reproduction, Nutrition and Development, 2006: 46: S122.
  • E. J. Leys, T. Premaraj, R. Rumpf and A.L. Griffin, "Bacteroides Forsythus Strain ATCC 43037 16S-23S Intergenic Spacer Region," Complete Sequence NCBI Nucleotide Sequence, 2002: AF466818.
  • A. Amano, T. Premaraj, M. Kuboniwa, I. Nakagawa, S. Shizukushi, I. Morisaki and S. Hamada, "Altered Antigenicity in Periodontitis Patients and Decreased Adhesion of Porphyromonas Gingivalis by Environmental Temperature Stress," Oral Microbiol Immunol 2001: 16: 124-128
  • T. Premaraj, N. Kato, K. Fukui, H. Kato and K. Watanabe, "Use of PCR and Sodium Dodecyl Sulphate Polyacrylamide Gel Electrophoresis Techniques for Differentiation of Prevotella Intermedia Sensu Stricto and Prevotella Nigrescens," Journal of Dental Research 1999: 37: 1057-1061
  • K. Fukui, T. Premaraj, N. Kato, H. Kato, K. Watanabe and N. Tatematsu "Incidence of Prevotella Intermedia and Prevotella Nigrescens Carriage Among Family Members with Sub Clinical Periodontal Disease," Japanese Journal of the Association for Anaerobic Infection 1999; 29:87-94
  • K. Fukui, N. Kato, T. Premaraj, H. Kato, K. Watanabe and N. Tatematsu, "Application of PCR Ribotyping to Prevotella Intermedia/Nigrescens and Intra-familial Transmission," Proceedings of the Annual Meeting of the Japanese Association for Anaerobic Infections Research; ISSN -09 13-3798; 1999:28; 64-69

Published Abstracts

  • J. Stengle, L. Talluri, I. Souza, T Premaraj and S. Premaraj, "Prostaglandin E2 Activates Beta-Catenin Signaling in Periodontal Ligament (PDL) Cells," Journal of Dental Research, 89 (Spec Iss B): 3748, 2010
  • S. Premaraj, I. Souza, L. Talluri, M. Guerrero, J. Barta, T. Premaraj, "Mechanical Strain Activates Beta-catenin Signaling in Periodontal Ligament (PDL) Cells," Journal of Dental Research, 89 (Spec Iss A): 1294, 2010
  • T. Premaraj, D. Defay, K. Vig, S. Shanker, F.M. Beck, A.R. Firestone, "Reliability and Validity of Orthognathic Quality of Life Questionnaire in American Population," Journal of Dental Research, 86 (Spec Iss A): 0474, 2007
  • D. Defay, T. Premaraj, A. Firestone, K. Vig, S. Shanker, F.M. Beck, "Reliability and Validity of Patient Interview Form," Journal of Dental Research, 86 (Spec Iss A): 2765, 2007
  • Q. Z. Xia, T. Yu, T. Premaraj, T. Williams and M. Morrison, "Real-time PCR and PCR-DGGE Analyses of Stool Microbiomes from Infants Fed Human Breast Bilk, Infant Formula, or Formula with Added Fructo-oligosaccharides," Fifth RRI-INRA Gastrointestinal Tract Microbiology Symposium. Aberdeen, Scotland, UK [Refereed] (Published), 2006
  • T. Premaraj, C. Igboin, A. L. Griffen, E. J. Leys, "Quantitation of Periodontal Pathogens by Real Time PCR," Journal of Dental Research, 83 (Spec Iss A): 3666, 2004

Research Communications

  • S. Premaraj, I. Souza and T. Premaraj, "Molecular Mechanisms of Tooth Movement, Emerging Concepts," paper presented at the 87th Congress of the European Orthodontic Society, June 19-23, 2011, Istanbul, Turkey
  • T Premaraj, I Souza, L Talluri, M. Guerrero, J. Barta and S. Premaraj, "Mechanical Strain Activates Beta-catenin signaling in Periodontal ligament (PDL) Cells," American Association of Orthodontists Meeting, Washington, DC, May 2010
  • Thyagaseely Premaraj, Zhongtang Yu and Mark Morrison, "Investigating the Cellulolytic Potential of Ruminococcus Callidus Isolated from Human Intestinal Tract," DARPA Intestinal Fortitude Meeting, Arlington, Virginia, June 21, 2006
  • Qing Xia, Zhongtang Yu, Thyagaseely Premaraj, Timberly Williams and Mark Morrison, "Real-time PCR and PCR-DGGE Analyses of Stool Microbiomes from Infants Fed human Breast Milk, Infant Formula, or Formula with Added Fructo-oligosaccharides," Abstract presented at the RRI-INRA conference, Scotland, June 2006
  • T. Premaraj, N. Nakagawa and S. Hamada, "Porphyromonas Gingivalis Fimbrial Binding Sites of Extracellular Matrix Protein Fibronectin," Poster presented at the Annual Sessions of the Japanese Society for Microbiology, Osaka, Japan, December 2000
  • T. Premaraj, N. Kato, K. Kato and K. Watanabe, "Discrepancies Between SDS - PAGE and PCR Techniques on the Differentiation of Prevotella Intermedia and Prevotella Nigrescens," 77th General Sessions of IADR; Vancouver, March 1998
  • T. Premaraj, N. Kato and K. Watanabe, "SDS- PAGE and Commercial Kit Identification of P. intermedia and P. nigrescens," Presented at the Annual Sessions of the Japanese Society for Microbiology, Nagoya, Japan, June 1999

Abstracts and Posters

  •  C. Carter, M. Makkawy and T. Premaraj, "Microbiology of Root Canal Infections" Poster, Professional Day, College of Dentistry 2013
  •  C. Hopke, S. Premaraj and T. Premaraj, "Electric Cell-Substrate Impedance Sensing Assessment of Epithelial Cell Micro Motion and Cell-cell Adhesion Behavior Following Exposure to Invislaign® Plastic," Annual Meeting of American Association of Orthodontics, Honolulu, Hawaii, May 2012
  •  A. Meyer, S. Premaraj, M. Beatty and T. Premaraj, "Oral Epithelial Cell Response to Orthodontic Plastic", Preliminary Report, Journal of Dental Research, 91 (Spec Iss B): 366, 2012
  •  K. Russell, T. Premaraj and S. Premaraj, "Expression of Chemokines in Periodontal Tissues During Orthodontic Tooth Movement," Journal of Dental Research, 91 (Spec Iss B): 641, 2012
  •  S. Premaraj, F. Chau and T. Premaraj, "Tooth Extraction/Hypofunction-Induced Changes in Alveolar Osteocyte Expression of SOST/Sclerostin," Journal of Dental Research, 91 (Spec Iss B): 1617, 2012

Funding Received 

  • Align® Technology Inc. Award, "Shift in Species Composition of Sub Gingival Microbiome as a Risk Factor in Periodontal Disease – A Comparative Study with Braces/Invisalign® Treatment", 2013
  • American Association of Orthodontic Foundation, Robert E. Binder Teaching Fellowship Teaching Award, 2013
  • Align® Technology Inc. Award, "Shift in Species Composition of Supra Gingival Microbiome as a Risk Factor in Dental Caries – A Comparative Study with Braces/Invisalign® Treatment", 2012
  • American Association of Orthodontic Foundation, Faculty Development Award. 2012

Professional Affiliations

  • American Association of Orthodontists
  • International Association of Dental Research
  • American Society of Microbiology
  • American Dental Association/Nebraska Dental Association
  • Midwest Society of Orthodontists
  • Sri Lanka Dental Association

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