UNMC College of Dentistry - Departments & Centers

Dr. Jeffrey B. Payne

Title: Associate Dean for Research, Professor, F. Gene and Rosemary Dixon Endowed Chair in Dentistry

Address
Room: 135E
UNMC College of Dentistry
40th and Holdrege
Box 830740
Lincoln, NE 68583-0740

Surgical Specialties Department
Cruzan Center for Applied Clinical Research
Bioregulation Group

Telephone: (402) 472-1318
Fax: (402) 472-6668
email: jbpayne@unmc.edu

Education:

Certificate (Periodontology), University of Connecticut School of Dental Medicine, Farmington, Connecticut
M.Dent.Sc. (Immunology), University of Connecticut School of Dental Medicine, Farmington, Connecticut
D.D.S., State University of New York at Stony Brook School of Dental Medicine, Stony Brook, New York
B.S. (Biology), Adelphi University, Garden City, New York

Teaching Responsibilities:

Perio 538 Theoretical Periodontology
Perio 331 Theoretical Periodontology
OB 471 A Review of Biomedical/Dental Sciences

Research Interests:

Periodontitis and systemic diseases (including osteoporosis)
Clinical periodontal pharmacologic interventions
Periodontitis clinical trials

Grants:

July 1, 2006 to December 31, 2008 Low-dose Doxycycline Effects on Osteopenic Bone Loss, National Institute of Dental and Craniofacial Research, Principle Investigator
July 1, 2001-June 30, 2006 Low-dose Doxycycline Effects on Osteopenic Bone Loss, National Institute of Dental and Craniofacial Research, Principle Investigator
July 1, 2001-June 30, 2006 Low-dose Doxycycline Effects on Osteopenic Bone Loss, National Institute of Dental and Craniofacial Research, Supplement, Principle Investigator

Completed Book Chapter:

Stoner, J.A., Payne, J.B. Subantimicrobial-dose doxycycline effects on alveolar bone loss in postmenopausal women. Example of a randomized controlled clinical trial. In Statistical and methodological aspects of oral health research, eds. Lesaffre, E., Feine, J., Leroux, B., Declerck, D., pp. 359-376. John Wiley & Sons, Ltd., 2009.

Recent Publications:

Mikuls, T.R., Payne, J.B., Reinhardt, R.A., Thiele, G.M., Maziarz, E., Cannella, A.C., Holers, V.M., Kuhn, K.A., O'Dell, J.R. Antibody responses to Porphyromonas gingivalis (P. givgivalis) in subjects with rheumatoid arthritis and periodontitis. Int Immunopharmacol 9:38-42, 2009.
Golub, L.M., Lee, H.M., Stoner, J.A., Sorsa, T., Reinhardt, R.A., Wolff, M.S., Ryan M.E., Nummikoski, P.V., Payne, J.B. Subantimicrobial dose doxycycline modulates gingival crevicular fluid biomarkers of periodontitis in postmenopausal osteopenic women. J Periodontol 79:1409-1418, 2008.
Stoner, J.A., Payne, J.B. Interpretation of treatment effects in periodontal research. A note on the number needed to treat. Journal of the Canadian Dental Association 74:435-437, 2008.
Payne, J.B., Stoner J.A., Nummikoski, P.V., Reinhardt, R.A., Goren, A.D., Wolff, M.S., Lee, H.M., Lynch, J.C., Valente, R., Golub, L.M. Subantimicrobial dose doxycycline effects on alveolar bone loss in postmenopausal women. J Clin Periodontol 34:776-787, 2007.
Preston, R.D., Meinberg, T.A., Payne, J.B., Schmid, M.J., Lee, H.M., Golub, L.M., Marx, D.B., Reinhardt, R.A. Inflammatory mediator release following bone grafting in humans: a pilot study. J Clin Periodontol 34:797-804, 2007.
Reinhardt, R.A., Stoner, J.A., Golub, L.M., Wolff, M.S., Lee, H.M., Meinberg, T.A., Lynch, J.C., Ryan, M.E., Sorsa, T., Payne, J.B. Efficacy of subantimicrobial dose doxycycline in postmenopausal women: clinical outcomes. J Clin Periodontol 34:768-775, 2007.
Walker, C., Puumala, S., Golub, L.M. Stoner, J.A., Reinhardt, R.A., Lee, H.M., Payne, J.B. Subantimicrobial dose doxycycline effects on osteopenic bone loss: microbiology results. J Periodontol 78:1590-1601, 2007.
Golub , L.M., Payne, J.B., Reinhardt, R.A., Neiman, G. Can Systemic Diseases Co-Induce (NOT just Exacerbate) Periodontitis? A Hypothetical "Two-Hit" Model. J Dent Res. 85:102-105, 2006.
Reinhardt, R.A., Lee, H.M., Schmid, M., Payne, J.B., Golub, L. Relationship between gelatinases and bone turnover in the healing bone defect. J Oral Maxillofac Surg 85:102-105, 2006.
Barnes, C.M., Russell, C.M., Reinhardt, R.A., Payne, J.B., Lyle, D.M. Comparison of irrigation to floss as an adjunct to tooth brushing: effect on bleeding, gingivitis, and supragingival plaque. J Clin Dent 16:71-77, 2005
Payne, J.B., Reinhardt, R.A., Nummikoski, P.V., Dunning, D.G., and Patil, K.D. The Association of Cigarette Smoking with Alveolar Bone Loss in Postmenopausal Females. J Clin Periodontol 2: 658-664, 2000.
Bavitz, J.B., Payne, J.B., Dunning, D., Glenn, A., and Koka, R. The Use of Distraction Osteogenesis to Induce New Suprabony Periodontal Attachment in the Beagle Dog. Int J Periodont & Restor Dent 20: 59-603, 2000.
Payne, J.B., Reinhardt, R.A., Nummikoski, P.V., and Patil, K.D. Longitudinal Alveolar Bone Loss in Postmenopausal Osteoporotic/Osteopenic Women. Osteoporos Int 10:34-40, 1999.
Reinhardt, R.A., Payne, J.B., Maze, C.A., Patil, K.D., Gallagher, S.J., and Mattson, J.S. Influence of Estrogen and Osteopenia/Osteoporosis on Clinical Periodontitis in Postmenopausal Women. J Periodontol 0:823-828, 1999.
Payne, J.B., and Reinhardt, R.A. Potential Application of Low-Dose Doxycycline to Treat Periodontitis in Post-Menopausal Women. Adv Dent Res 12:166-169, 1998.
Golub, L.M., Lee, H.M., Ryan, M.E., Giannobile, W.V., Payne, J., and Sorsa T. Tetracyclines Inhibit Connective Tissue Breakdown by Multiple Non-Antimicrobial Mechanisms. Adv Dent Res 12:12-26, 1998.
Reinhardt, R.A., Payne, J.B., Maze, C., Babbitt, M., Nummikoski, P.V., and Dunning, D. Gingival Fluid IL-1Beta in Postmenopausal Females on Supportive Periodontal Therapy: A Longitudinal Two-Year Study. J Clin Periodontol 25:1029-1035, 1998.
Payne, J.B., Johnson, G.K., Reinhardt, R.A., and Schmid, M. Histological Alterations Following Short-Term Smokeless Tobacco Exposure in Humans. J Periodont Res 33:24-29, 1998.
Johnson, G.K., Payne, J.B., Fili, J.M., Reinhardt, R.A., Organ, C.C., and Slager, S.L. Development of Smokeless Tobacco-Induced Oral Mucosal Lesions. J Oral Pathol Med 2:388-394, 1998.
Bernzweig, E., Payne, J.B., Reinhardt, R.A., Dyer, J.K., and Patil, K.D. Nicotine and Smokeless Tobacco Effects on Gingival and Peripheral Blood Mononuclear Cells. J Clin Periodontol 25:246-252, 1998.
Bowley, J.F., Payne, J.B., and Stockstill, J.W. Management of the Gingival Sulcus in Fixed Prosthodontics: A Literature Review and Treatment Protocol. Compendium Continuing Educ Dent 19:154-162, 1998.
Johnson, T.C., Reinhardt, R.A., Payne, J.B., Dyer, J.K., and Patil, K.D. Experimental Gingivitis in Periodontitis Susceptible Subjects. J Clin Periodontol 24: 618-625, 1999.
Payne, J.B., Zachs, N.R., Reinhardt, R.A., Nummikoski, P.V., and Patil, K. The Association Between Estrogen Status and Alveolar Bone Density Changes in Postmenopausal Women with a History of Periodontitis. J Periodontol 68:24-31, 1999.
Maze, G.I., Reinhardt, R.A., Payne, J.B., Maze, C., Baker, R.A., Bouwsma, O.J., Damani, N.C., Fitzgerald, J., Hamlin, J.C., and Gerlach, R.W. Gingival Fluid Tetracycline Release from Bioerodible Gels. J Clin Periodontol 23: 1133-1136, 1996.
Payne, J.B., Johnson, G.K., Reinhardt, R.A., Dyer, J.K., Maze, C.A., and Dunning, D.G. Nicotine Effects on PGE2 and IL-1Beta Release by LPS-Treated Human Monocytes. J Periodont Res 31: 99-104, 1996.
Johnson, G.K., Poore, T.K., Payne, J.B., and Organ, C.C. Effect of Smokeless Tobacco Extract on Human Gingival Keratinocyte Levels of Prostaglandin E2 and IL-1. J Periodontol 6: 116-124, 1996.
Payne, J.B., Johnson, G.K., Reinhardt, R.A., Maze, C.R., Dyer, J.K., and Patil, K.D. Smokeless Tobacco Effects on Monocyte Secretion of PGE2 and IL-1Beta. J Periodontol 65:93-941, 1994.
Manhart, S.S., Reinhardt, R.A., Payne, J.B., Seymour, G.J., Gemmel, E., Dyer, J.K., and Petro, T.M. Gingival Cell IL-2 and IL-4 in Early-Onset Periodontitis. J Periodontol 65:80-813, 1994.
Reinhardt, R.A., Masada, M.P., Payne, J.B., Allison, A.C., and DuBois, L.M. Gingival Fluid IL-1Beta and IL-6 Levels in Menopause. J Clin Periodontol 21:22-25, 1994.
Payne, J.B., Reinhardt, R.A., Masada, M.P., DuBois, L.M., and Allison, A.C. Gingival Crevicular Fluid IL-8: Correlation With Local IL-1Beta Levels and Patient Estrogen Status. J Periodont Res 28:451-453, 1993.
Koka, S., Payne, J.B., and Chaffee, N.R. Treatment of Buccally Placed Implants in the Edentulous Mandible: Clinical Report. Implant Dentistry 2:186-188, 1993.
Payne, J.B., Peluso, J.F., and Nichols, F.C. Longitudinal Evaluation of Peripheral Blood Monocyte Secretory Function in Periodontitis-Resistant and Periodontitis-Susceptible Patients. Arch Oral Biol 38:309-31, 1993.
Payne, J.B., Nichols, F.C., and Peluso, J.F. The Effects of IFN-Gamma and Bacterial Lipopolysaccharide on CD14 Expression in Human Monocytes. J Interferon Res 12(4):30-310, 1992.
Payne, J.B. Gingival Hyperplasia: Etiology, Clinical Presentation, Prevention and Treatment. Dental Teamwork (ADA Publishers, Inc.) 5(5):22-24, 1992.
Payne, J.B., Iacono, V.J., Crawford, I.T., Lepre, B.M., Bernzweig, E., and Grossbard, B.L. Differential Effects of Histidine-Rich Polypeptides on the Viability of Streptococcus mutans and Streptococcus sanguis. Oral Microbiol Immunol 6:169-16, 1991.
Nichols, F.C., Peluso, J.F., Tempro, P.J., Garrison, S.W., and Payne, J.B. PGE Release From Human Monocytes Treated With Lipopolysaccharide Isolated From Bacteroides intermedius and Salmonella typhimurium: Potentiation by Gamma Interferon. Infect Immun 59:398-406, 1991.
Foerth, D., Payne, J. and Foerth, S. Use of an Incisal Guide Plate to Achieve Anterior Guidance for a Skeletal Class II Patient: A Clinical Report. J Prosthet Dent 61:263-265, 1989.

Abstracts:

Payne, J.B., Stoner, J.A., Lee, H.M., Golub, L.M. Subantimicrobial-dose doxycycline effects on serum inflammatory biomarkers in postmenopausal-osteopenic-women with periodontitis. J Dent Res 88 (Spec. Is.):Abstract:2916, 2009.
Golub, L.M., Lee, H.M., Stoner, J.A., Payne, J.B. Serum gelatinases Type IV collagenases in postmenopausal-osteopenic women with periodontitis: subantimicrobial-dose-doxycycline (SDD). J Dent Res 88 (Spec. Is.):Abstract 3512, 2009.
Reinhardt, R.A., Stoner, J.A., Golub, L.M., Lee, H.M., Payne J.B. GCF MMP-8 in postmenopausal women. Association with progressive attachment loss. J Dent Res 88 (Spec. Is):Abstract 2917, 2009.
Mikuls, T.R., Payne, J.B., Reinhardt, R.A., Thiele, G.M., Maziarz, E., Cannella, A.C., Holers, V.M. Kuhn, K.A., Bergman, D.A., O'Dell, J.R. Immunity to the oral pathogen, Porphyromonas gingivalis (P. givgivalis) in subjects with rheumatoid arthritis and periodontitis. Arthritis Rheum 58(suppl), s274, 2008.
Reinhardt, R.A., Stoner, J.A., Golub, L.M., Lee, H.-M., Payne, J.B. Longitudinal GCF biomarkers associated with ongoing clinical attachment loss. J Periodontol 79:1818-1819, 2008.
Payne, J.B., Stoner, J.A., Lee, H.M., Nummikoski, P.V., Reinhardt, R.A., Valente, R., Golub, L.M. Serum bone-resorption biomarkers: correlation with alveolar and systemic bone changes. J Dent Res 87 (Spec. Is.): Abstract 1558, 2008.
Golub, L.M., Lee, H.M., Stoner, J.A., Reinhardt, R.A., Sorsa, T., Goren, A.D., Payne, J.B. Bone-turnover markers in postmenopausal osteopenic women with periodontitis (POWP): Subantimicrobial-dose doxycycline (SDD). J Dent Res 87 (Spec. Is.): Abstract 3491, 2008.
Reinhardt, R.A., Stoner, J.A., Lee, H.M., Nummikoski, P.V., Golub, L.M., Payne, J.B. Crevicular fluid resorption marker: correlations with alveolar and systemic bone changes. J Dent Res 87 (Spec. Is.): Abstract 2909, 2008.
Reinhardt, R.A., Stoner, J.A., Golub, L.M., Wolff, M.S., Lee, H.M., Lynch, J.C., Nummikoski, P.V., Goren, A.D., Sorsa, T., Payne, J.B. Subantimicrobial-dose doxycycline in postmenopausal osteopenic women with periodontitis: clinical outcomes. J Dent Res 86 (Spec. Is.): Abstract 1331, 2007.
Payne, J.B., Nummikoski, P.V., Stoner, J.A., Reinhardt, R.A., Goren, A.D., Wolff, M.S., Lee, H.M., Lynch, J.C., Gruber, B., Golub, L.M.. Subantimicrobial-dose doxycycline in postmenopausal osteopenic women with periodontitis: radiographic outcomes. J Dent Res 86 (Spec. Is.): Abstract 1332, 2007.
Walker, C., Puumala, S.E., Golub, L.M., Stoner, J.A., Reinhardt, R.A., Lee, H.M., Payne, J.B. Low-dose doxycycline effects on osteopenic bone loss: microbiology results. J Dent Res 86 (Spec. Is.): Abstract 1333, 2007.
Golub, L.M., Lee, H.M., Stoner, J.A., Sorsa, T., Reinhardt, R.A., Wolff, M.S., Ryan, M.E., Payne, J.B. Subantimicrobial-dose doxycycline (SDD) in postmenopausal osteopenic women with periodontitis: GCF biomarkers. J Dent Res 86 (Spec. Is.) Abstract 1334, 2007.
Payne, J.B., Stoner, J.A., Reinhardt, R.A., Wolff, M.S., Lynch, J.C., Layton, J.A., Lee, H-M, Lahners, A., Meinberg, T., Goren, A.D., Ryan, M.E., Golub, L.M. Doxycycline effects on osteopenic bone loss: trial design and recruitment. J Dent Res 84 (Spec. Is.): Abstract 1537, 2005
Wilde, J.C., Koka, S., Pahan, K., Petro, T.M., and Payne, J. TNF-α Stimulated Production of IL-6 via MAP Kinase Pathways.J Periodontol 72:1634, 2001.
Payne, J.B., Reinhardt, R.A., Nummikoski, P.V., and Golub, L.M. Doxycycline Effects on Oral Bone Loss in Postmenopausal Women. J Dent Res (Spec. Is.): 55, 2001.
Payne, J.B., Reinhardt, R.A., Nummikoski, P.V., Dunning, D.G., and Patil, K.D. Smoking-Induced Alveolar Bone Loss in Postmenopausal Females. J Dent Res 79 (Spec.Is.):236, 2000.
Peterson, G.E., Nummikoski, P.V., Payne, J.B., and Reinhardt, R.A. Osteoporosis Status and Radiographic Fractal Dimension of the Mandibular Bone. J Dent Res 79 (Spec.Is.):456, 2000.
Cohen, D.M., Lee, H.M., Bhattacharyya, I., Sensat, M.L., Payne, J.B., and Golub, L.M. Effective Treatment for Cicatrical Pemphigoid Using A Novel Combination Therapy. J Dent Res 79 (Spec.Is.):627, 2000.
Meyer, C., Reinhardt, R., Maze, C., Koka, S., and Payne, J. Estrogen and LPS Effects on Monocyte CD14 and IL-1βSecretion. J Dent Res 78 (Spec.Is.):427, 1999.
Whitlock, S., Payne, J., Koka, S., and Hunzeker, C. Doxycycline Effects on TNF-α Stimulated Osteoblast-Derived IL-6. J Dent Res 78 (Spec.Is.):431, 1999.
Reinhardt, R., Payne, J., Maze, C., and Patil, K. Clinical Characteristics of Postmenopausal Women on Supportive Periodontal Treatment. J Dent Res 78 (Spec.Is.): 458, 1999.
Weenig, D., Johnson, G., Payne, J., Reinhardt, R., and Organ, C. Salivary Nicotine and Cotinine Concentration in Smokeless Tobacco Users. J Dent Res 77 (Spec.Is.):180, 1998.
Payne, J.B., Johnson, G.K., Reinhardt, R.A., and Schmid, M. Histological and Clinical Development of Smokeless Tobacco Lesions in Humans. J Dent Res 77 (Spec.Is.):181, 1998.
Reinhardt, R.A., Payne, J.B., Babbitt, M., Nummikoski, P., Maze, C.A., and Dunning, D. Gingival Fluid IL-1β in Postmenopausal Females on Supportive Periodontal Therapy. J Dent Res 77 (Spec.Is.):230, 1998.

Service Activities:

Chair, Research Committee
Chair, Board of Directors for the Cruzan Center for Dental Research
Member, University of Nebraska Medical Center Research Advisory Board
Member, College of Dentistry LB 605 Steering Committee
Member, College of Dentistry Leadership Council
Member, College of Dentistry Administrative Review Committee
Member, College of Dentistry Strategic Planning Committee
Member, UNMC Conflict of Interest in Academic Settings Committee
Consultant, Veterans Administration Medical Center, Lincoln NE