Amar Natarajan, Ph.D., Associate Professor
Chemical probes for protein-protein interactions
Associate Professor Eppley Institute
Ph.D. University of Vermont
Research Interests
Phosphorylation and de-phosphorylation reactions of cellular proteins are ubiquitous in nature and represent the molecular on/off switch that triggers innumerable signaling events mediated by phospho-specific protein-protein interactions. Our research interest focuses on the use of small molecules to perturb these phospho-specific protein-protein interactions as a first step towards understanding how cells exploit these interactions in signal transduction. Chemical probes for this effort are derived from natural products and the design of conformationally constrained mimics. Synthetic chemistry spearheads the research program, however, biology and computational methods are used synergistically in our quest for a better comprehension of the cellular events contiguous to phospho-specific protein-protein interactions.
Phosphoprotein binding site on BRCT(BRCA1)
(+) Okilactomycin (in progress)
Phone: (402) 559 3793
Email: anatarajan@unmc.edu
Back row: Abijah, Eric, Vashti, Qian-Yi
Front row: Devalina, Smitha, Ziyan
Amar Natarajan, Ph.D., Associate Professor
Chemical probes for protein-protein interactions
Associate Professor Eppley Institute
Ph.D. University of Vermont
Research Interests
Phosphorylation and de-phosphorylation reactions of cellular proteins are ubiquitous in nature and represent the molecular on/off switch that triggers innumerable signaling events mediated by phospho-specific protein-protein interactions. Our research interest focuses on the use of small molecules to perturb these phospho-specific protein-protein interactions as a first step towards understanding how cells exploit these interactions in signal transduction. Chemical probes for this effort are derived from natural products and the design of conformationally constrained mimics. Synthetic chemistry spearheads the research program, however, biology and computational methods are used synergistically in our quest for a better comprehension of the cellular events contiguous to phospho-specific protein-protein interactions.
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Phosphoprotein binding site on BRCT(BRCA1)
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(+) Okilactomycin (in progress)
Phone: (402) 559 3793 Email: anatarajan@unmc.edu
Back row: Abijah, Eric, Vashti, Qian-Yi
Front row: Devalina, Smitha, Ziyan
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