Grinu Mathew, PhD
Assistant Professor, UNMC Eppley Institute for Research in Cancer and Allied Diseases
Research focus: Genetic and epigentic regulation of prostate cancer metastasis
Grinu Mathew, PhD, is an assistant professor in the UNMC Eppley Institute for Research in Cancer and Allied Diseases.
Her lab studies the genetic and epigenetic regulation of prostate cancer metastasis, investigating adaptive cell fate decisions and signal transduction networks utilized by cancer cells during the metastatic cascade. The main areas of interest are: transcriptional regulation of indolent to metastatic switch, decoding cellular fitness phenotypes leading to therapy resistance, and molecular mechanisms of whole genome duplication in cancer.
Her team combines mouse genetics, whole organ imaging, cell biology, and biochemical techniques to integrate and interpret how cancer cells adapt to selective pressures and the dynamic ecosystems arising during malignant transformation and metastasis. These mechanistic insights will provide a better grasp on the genetic dependencies of metastatic cells and boost the development of novel therapeutic approaches towards a lethal form of disease.