Jing (Jenny) Wang, Ph.D., Selected Publications

Wang, J, L.Z. Sun, L. Myeroff, X.F. Wang, L.E. Gentry, J.Yang, J. Liang, E. Zborowska, S. Markowitz, J.K.V. Willson and M.G. Brattain. 1995. Demonstration that mutation of the type II TGFß receptor inactivates its tumor suppressor activity in RER positive colon carcinoma cells. J. Biol. Chem. 270: 22044-22049.

Markowitz S., Wang J, L. Myeroff, R. Parsons, L.Z. Sun, J. Lutterbaugh, R.S. Fan, E. Zborowska, K. W. Kinzler, B. Vogelstein, M.G. Brattain and J.K.V. Willson. 1995. Inactivation of Type II TGFß receptor in colon cancer cells with microsatellite instability. Science 268: 1336-1338. * Co-first author.

Sun, L.Z., G. Wu, J.K.V. Willson, E. Zborowska, J.Yang, I. Rajakarunayaka , Wang J, L.E. Gentry, X. F. Wang and M.G. Brattain. 1994. Expression of Transforming Growth Factor Beta Type II receptor leads to reduced malignancy in human breast cancer MCF-7 cells. J. Biol. Chem. 269: 26449-26455.

Wang J, W. Han, E. Zborowska, J. Liang, X. F. Wang, J.K.V. Willson, L.Z. Sun and M.G. Brattain. 1996. Reduced expression of TGFß type I receptor contributes to the malignancy of human colon carcinoma cells. J. Biol. Chem. 271: 17366-17371.

Wang J, Xie L-Y, Allan S, Beach D and Hannon G. 1998. Myc activates telomerase. Genes & Dev 12: 1769-1774.

Wang J, Hannon G and Beach D. 2000. Risky immortalization by telomerase. Nature 405: 755-756.

Wang J, Sergina N, Ko TC, Gong J and Brattain MG. 2004. Autocrine and exogenous transforming growth factor beta control cell cycle inhibition through pathways with different sensitivity. J Biol Chem. 279: 40237-44.

Kondoh H, Lleonart M, Wang J, Gil J, Degan P, Peters G, Martinez D, Carnero A and Beach D. 2005.Glycolytic enzymes can modulate cellular life span. Cancer Res. 65: 177-185.

Zhou Y, Li S, Zborowska E, Hu PY, Wang J, Hauser J, Conway A, Vinci MA, Humphrey L, Willson JKV and Brattain MG. 2006 Blockade of EGFR and ErbB2 by a Novel Dual EGFR and ErbB2 TKI GW572016 Sensitizes Human Colon Carcinoma GEO Cells to Apoptosis. Cancer Res. 66(1): 404-11. 

Wang J, Kuropatwinski K, Hauser J, Rossi MR, Zhou Y, Conway A, Kan JLC, Gibson NW, Willson JKV, Cowell JK and Brattain MG. 2007 Colon Carcinoma Cells Harboring PIK3CA Mutations Display Resistance to Growth Factor Deprivation Induced Apoptosis. Mol Cancer Ther.6(3):1143-50. 

Guo X, Rajput A, Rose R, Hauser J, Beko A, Kuropatwinski K, LeVea C, Hoffman RM, Brattain MG and Wang J. 2007 Mutant PIK3CA-bearing colon cancer cells display increased metastasis in an orthotopic model. Cancer Res.67(12): 5851-8. 

Rajput A, Dominguez I, Rose R, Beko A, LeVea C, Sharratt E, Mazurchuk R, Hoffman RM, Brattain MG and Wang J. 2008 Characterization of HCT 116 Human Colon Cancer Cells in an Orthotopic Model. J Surgical Res.147: 276-81. 

Wang J, Yang L, Yang J, Kuropatwinski K, Wang W, Liu XQ, Hauser J and Brattain MG. 2008 Transforming Growth Factor b Induces Apoptosis through Repressing the Phosphoinositide 3-kinase/AKT/Survivin Pathway in Colon Cancer Cells. Cancer Res. 68 (9): 3152-60. 

Zhao S, Ammanamanchi S, Brattain M, Cao L, Thangasamy A, Wang J and Freeman JW. 2008 Smad4-dependent TGF-b signaling suppresses RON receptor tyrosine kinase dependent motility and invasion of pancreatic cancer cells. J Biol Chem. 283(17): 11293-301. 

Wang J*, Rajput A, Kan JLC, Rose R, Liu XQ, Kuropatwinski K, Hauser J, Beko A, Dominquez I, Sharratt EA, Brattain L, LeVea C, Sun FL, Keane DM, Gibson NW and Brattain MG. 2009 Knockdown of Ron kinase inhibits activation of mutant PI3K and reduces metastasis in an orthotopic model of human colon cancer cells. J Biol. Chem. 284(16): 10912-22. *Corresponding author 

Ongchin M, Sharratt E, Dominguez I, Simms N, Wang J, Cheney R, Levea C, Brattain M and Rajput A. The Effects of Epidermal Growth Factor Receptor Activation and Attenuation of the TGFbPathway in an Orthotopic Model of Colon Cancer. J Surg Res.2009 Mar 5. 

Humbert N, Navaratnam N, Augert A, Da Costa M, Martien S, Wang J, Martinez D, Abbadie C, Carling D, de Launoit Y, Gil J and Bernard D. 2010 Regulation of ploidy and senescence by the AMPK-related kinase NUAK1. EMBO J 29(2): 376-86. 

Jiang Y, Liu XQ, Rajput A, Liying Geng, Ongchin M, Taylor G, Zeng Q and Wang J. 2011 Phosphatase PRL-3 is a direct regulatory target of TGFb in colon cancer metastasis. Cancer Res. 71(1): 234-44. 

Liu X-Q, Rajput A, Geng L, Ongchin M, Chaudhuri A and Wang J. 2011 Restoration of transforming growth factor b Receptor II expression in colon cancer cells with microsatellite instability increases metastatic potential in vivo. J Biol. Chem. 286(18): 16082-90. 

Hou J, Dong J, Sun L, Geng L, Wang J, Zheng J, Li Y, Bridge J, Hinrichs SH and Ding S-J. 2011 Inhibition of phosphorylated c-Met in rhabdomyosarcoma cell lines by a small molecule inhibitor SU11274. J. Translational Med. In press