Eppley Institute for Research in Cancer and Allied Diseases

Recent Publications

Fernandez M.R., Henry M.D., Lewis R.E..  Kinase Suppressor of Ras-2 (KSR2) Regulates Tumor Cell Transformation Via AMPK. Mol. Cell. Biol., 32(18), 3718-3731, (2012).

Klutho P.J., Costanzo-Garvey D.L., Lewis R.E.. Regulation of Glucose Homeostasis by KSR1 and MARK2.  PLoS One. 6(12):e29304.doi6:10.1371/journal.pone.0029304, Dec 19. (2011).

Xiao L., Chen Y., Ji M., Volle D.J., Lewis R.E., Tsai M.Y., Dong J.. KIBRA protein phosphorylation is regulated by mitotic kinase aurora and protein phosphatase 1.  J. Biol. Chem., 286(42): 36304-36315 (2011).

Fisher K.W., Das B., Kortum R.L., Chaika O.V., Lewis R.E..  Kinase Suppressor of Ras 1 (KSR1) Regulates PGC1α and Estrogen-Related Receptor α To Promote Oncogenic Ras-Dependent Anchorage-Independent Growth. Mol. Cell. Biol., 31, 2453-2461, (2011). 

Costanzo-Garvey D.L., Pfluger P.T., Dougherty M.K., Stock J.L., Boehm M., Chaika O., Fernandez M.R., Fisher K., Kortum R.L., Hong E.G., Jun J.Y., Ko H.J., Schreiner A., Volle D.J., Treece T., Swift A.L., Winer M., Chen D., Wu M., Leon L.R., Shaw A.S., McNeish J., Kim J.K., Morrison D.K., Tschop M.H., Lewis R.E.. KSR2 Is an Essential Regulator of AMP Kinase, Energy Expenditure, and Insulin Sensitivity.  Cell Metab., 10(5), 366-378 (2009). 

Razidlo G.L., Johnson H.J., Stoeger S.M., Cowan K.H., Bessho T., Lewis R.E..  KSR1 is required for cell cycle re-initiation following DNA damage.  J. Biol. Chem.,  284, 6705-6715 (2009).

Giurisato, E., Lin J., Harding, A., Cerutti, E., Cella, M., Lewis, R.E., Colonna, M., and Shaw, A.S.  The MAP Kinase Scaffold KSR1 is Required for Recruitment of ERK to the Immunological Synapse.  Mol. Cell. Biol.,  29, 1554-1564 (2009)

Casar, B,, Arozarena, I., Sanz-Moreno, V., Pinto, A., Agudo-Ibanez, L., Marais, R., Lewis, R.E., Berciano, M.T., Crespo, P. Ras subcellular localization defines ERK1/2 substrate specificity through distinct utilization of scaffold proteins.  Mol. Cell. Biol., 29, 1338-1353 (2009)

Chen, C., Lewis, R.E., and White, M.A.  IMP modulates KSR1-dependent multivalent complex formation to specify ERK1/2 pathway activation and response thresholds.  J Biol Chem., 283, 12789-96 (2008)

Selected List of Publications

Fusello, A.M,, Mandik-Nayak, L., Shih, F., Lewis, R.E., Allen, P.M., Shaw, A.S. The MAPK scaffold kinase suppressor of Ras is involved in ERK activation by stress and proinflammatory cytokines and induction of arthritis.  J Immunol. 177, 6152-8 (2006)

Kortum, R.L., Johnson, H.J., Costanzo, D.L., Volle, D. J., Razidlo, G.L., Fusello, A.M., Shaw A.S., and Lewis R.E. The Molecular Scaffold Kinase Suppressor of Ras 1 (KSR1) is a Modifier of RasV12-Induced and Replicative Senescence.  Mol. Cell. Biol., 26, 2202-2214 (2006)

Robertson, S.E., Rao, S., Setty, G., Sitaram, A., Marks, M.S., Lewis, R.E., and Chou, M.M. Erk Signaling Regulates Clathrin-independent Endosomal Trafficking.   Mol. Biol. Cell, 17, 645-657 (2006)

Kortum, R.L., Costanzo, D., Haferbier, J., Schreiner, S., Razidlo, G.L., Wu, M.-H., Volle, D. J., Wu, M.-H., Mori, T., Sakaue, H., Chaika, N.V., Chaika, O.V., and Lewis, R.E. The Molecular Scaffold Kinase Suppressor of Ras 1 (KSR1) Regulates Adipogenesis.  Mol. Cell. Biol., 25, 7592-7604 (2005)

Kim M., Kortum, R.L., Yan, Y., Stoeger, S., Sgagias, M., Lewis, R.E. and Cowan, K.H.  Kinase Suppressor of Ras (KSR) Enhances Sensitivity to cis-Platinum (CDDP) and CDDP-Induced Activation of Extracellular Ligand-Regulated Kinase (ERK).  Cancer Res., 65, 3986-3992 (2005)

Razidlo G.L., Kortum, R.L., Haferbier, J.L., and Lewis, R.E.  Phosphorylation Regulates KSR1 Stability, ERK Activation, and Cell Proliferation.   J. Biol. Chem. 279, 47808-47818 (2004)

R.L. Kortum and R.E. Lewis. The Molecular Scaffold KSR1 Regulates the Proliferative and Oncogenic Potential of Cells.  Mol. Cell. Biol. 24, 4407-4416 (2004)

Matheny, S.A., Chen, C., Kortum, R.L., Razidlo, G.L. Lewis, R.E., White, M.A. Ras regulates assembly of mitogenic signaling complexes through the effector protein IMP.  Nature, 427, 256-260 (2004)

Koka, S., Neudauer, C., Li, X., Lewis, R. McCarthy, J. B. and Westendorf, J.J. The Formin Homology Domain-Containing Protein , FHOD1, Enhances Cell Migration,  J. Cell Sci., 116, 1745-1755 (2003)

Petrovas, C., Jeay, S. Lewis, R.E. and Sonenshein, G.S. B-Myb Repressor Function is Regulated by Cyclin A Phosphorylation and Sequences within the C-terminal Domain,  Oncogene, 22, 2011-2020 (2003)

Nguyen, A., Burack, W.R., Stock, J.L., Kortum, R.L., Chaika, O.V., Afkarian, M., Muller, W.J., Murphy, K.M., Morrison, D.K., Lewis, R.E., McNeish, J., and Shaw, A.  Kinase Suppressor of Ras (KSR) is a scaffold which facilitates Mitogen Activated Protein Kinase Activation in vivo.  Mol. Cell. Biol., 22, 3035-3045 (2002)

Brennan, J.A., Chaika, O.V., Volle, and Lewis, R.E. Phosphorylation Regulates the Nucleo-Cytoplasmic Distribution of Kinase Suppressor of Ras.  J. Biol. Chem. 277, 5369-5377 (2002)

Johnson, L.R., Johnson, T.K., M. Desler, Luster, T.A., T. Nowling, Lewis, R.E., and Rizzino, A. Effects of B-Myb on Gene Transcription: Phosphorylation-Dependent Activity and Acetylation by p300.  J. Biol. Chem., 277, 4088-4097 (2002)

Johnson, T.K., Schweppe, R.E., Septer, J. and Lewis, R.E. Phosphorylation of B-Myb Regulates its Transactivation and DNA Binding. J. Biol. Chem., 274, 36741-36749 (1999)

Boehm, J. E., Chaika, O.V., and Lewis, R.E. Rac-dependent Anti-apoptotic Signaling by the Insulin Receptor Cytoplasmic Domain. J. Biol. Chem. 274, 28632-28636 (1999)

Volle, D.J., Fulton, J.A., Chaika, O.V., Huang, H., McDermott, K., Steinke, L.A. and Lewis, R.E. Phosphorylation of Kinase Suppressor of Ras by Associated Kinases. Biochemistry 38, 5130-5137 (1999)

Joneson, T., Fulton, J.A., Volle, D.J., Chaika, O.V., Bar-Sagi, D. and Lewis, R.E. KSR Inhibits the Activation of ERK MAP Kinase by Growth Factors, Activated Ras and Ras Effectors. J. Biol. Chem. 273, 7743-7748 (1998)

Boehm, J.E., Chaika, O.V. and Lewis, R.E. Anti-apoptotic Signaling by a CSF-1 Receptor/Insulin Receptor Chimera. J. Biol. Chem. 273, 7169-7176 (1998)