Ellen Duysen

Research Technologist II

University of Nebraska Medical Center
986805 Nebraska Medical Center ECI 6017
Omaha, NE 68198-6805

Tel: (402) 559-6014
Fax: (402) 559-4651
E-mail: eduysen@unmc.edu

Education:

Selected Publications:

Bytyqi AH, Lockridge O, Duysen E, Wang Y, Wolfrum U, Layer PG. Impaired formation of the inner retina in an AChE knockout mouse results in degeneration of all photoreceptors. Eur J Neurosci. 2004 Dec;20(11):2953-62.

Peeples ES, Schopfer LM, Duysen EG, Spaulding R, Voelker T, Thompson CM, Lockridge O. Albumin, a new biomarker of organophosphorus toxicant exposure, identified by mass spectrometry. Toxicol Sci. 2005 Feb;83(2):303-12. Epub 2004 Nov 3.

Adler M, Manley HA, Purcell AL, Deshpande SS, Hamilton TA, Kan RK, Oyler G, Lockridge O, Duysen EG, Sheridan RE. Reduced acetylcholine receptor density, morphological remodeling, and butyrylcholinesterase activity can sustain muscle function in acetylcholinesterase knockout mice. Muscle Nerve. 2004 Sep;30(3):317-27.

Wang Y, Schopfer LM, Duysen EG, Nachon F, Masson P, Lockridge O. Screening assays for cholinesterases resistant to inhibition by organophosphorus toxicants. Anal Biochem. 2004 Jun 1;329(1):131-8.

Wang Y, Boeck AT, Duysen EG, Van Keuren M, Saunders TL, Lockridge O. Resistance to organophosphorus agent toxicity in transgenic mice expressing the G117H mutant of human butyrylcholinesterase. Toxicol Appl Pharmacol. 2004 May 1;196(3):356-66.

Volpicelli-Daley LA, Hrabovska A, Duysen EG, Ferguson SM, Blakely RD, Lockridge O, Levey AI. Altered striatal function and muscarinic cholinergic receptors in acetylcholinesterase knockout mice. Mol Pharmacol. 2003 Dec;64(6):1309-16.

Li B, Duysen EG, Volpicelli-Daley LA, Levey AI, Lockridge O. Regulation of muscarinic acetylcholine receptor function in acetylcholinesterase knockout mice. Pharmacol Biochem Behav. 2003 Mar;74(4):977-86.

Duysen EG, Fry DL, Lockridge O. Early weaning and culling eradicated Helicobacter hepaticus from an acetylcholinesterase knockout 129S6/SvEvTac mouse colony. Comp Med. 2002 Oct;52(5):461-6.

Duysen EG, Bartels CF, Lockridge O. Wild-type and A328W mutant human butyrylcholinesterase tetramers expressed in Chinese hamster ovary cells have a 16-hour half-life in the circulation and protect mice from cocaine toxicity. J Pharmacol Exp Ther. 2002 Aug;302(2):751-8.

Duysen EG, Stribley JA, Fry DL, Hinrichs SH, Lockridge O. Rescue of the acetylcholinesterase knockout mouse by feeding a liquid diet; phenotype of the adult acetylcholinesterase deficient mouse. Brain Res Dev Brain Res. 2002 Jul 30;137(1):43-54.

Duysen EG, Li B, Xie W, Schopfer LM, Anderson RS, Broomfield CA, Lockridge O. Evidence for nonacetylcholinesterase targets of organophosphorus nerve agent: supersensitivity of acetylcholinesterase knockout mouse to VX lethality. J Pharmacol Exp Ther. 2001 Nov;299(2):528-35.

Yaktine AL, Vaughn R, Blackwood D, Duysen E, Birt DF. Dietary energy restriction in the SENCAR mouse: elevation of glucocorticoid hormone levels but no change in distribution of glucocorticoid receptor in epidermal cells. Mol Carcinog. 1998 Jan;21(1):62-9.

Birt DF, Pour PM, Nagel DL, Barnett T, Blackwood D, Duysen E. Dietary energy restriction does not inhibit pancreatic carcinogenesis by N-nitrosobis-2-(oxopropyl)amine in the Syrian hamster. Carcinogenesis. 1997 Nov;18(11):2107-11.

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