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Education: Selected Publications: Oksana Lockridge, Lawrence M. Schopfer, Gail Winger, James H. Woods. Large scale purification of butyrylcholinesterase from human plasma suitable for injection into monkeys; a potential new therapeutic for protection against cocaine and nerve agent toxicity. J Med CBR Def. Volume 3, 2005 Schopfer LM, Voelker T, Bartels CF, Thompson CM, Lockridge O. Reaction kinetics of biotinylated organophosphorus toxicant, FP-biotin, with human acetylcholinesterase and human butyrylcholinesterase. Chem Res Toxicol. 2005 Apr;18(4):747-54. Peeples ES, Schopfer LM, Duysen EG, Spaulding R, Voelker T, Thompson CM, Lockridge O. Albumin, a new biomarker of organophosphorus toxicant exposure, identified by mass spectrometry. Toxicol Sci. 2005 Feb;83(2):303-12. Epub 2004 Nov 3. Lawrence M. Schopfer, Andreea Ticu Boeck, Clarence A. Broomfield, Oksana Lockridge. Mutants of human butyrylcholinesterase with organophosphate hydrolase activity; evidence that His117 is a general base catalyst for hydrolysis of echothiophate. J Med Chem Def Volume 2, 2004 Wang Y, Schopfer LM, Duysen EG, Nachon F, Masson P, Lockridge O. Screening assays for cholinesterases resistant to inhibition by organophosphorus toxicants. Anal Biochem. 2004 Jun 1;329(1):131-8. Masson P, Bec N, Froment MT, Nachon F, Balny C, Lockridge O, Schopfer LM. Rate-determining step of butyrylcholinesterase-catalyzed hydrolysis of benzoylcholine and benzoylthiocholine. Volumetric study of wild-type and D70G mutant behavior. Eur J Biochem. 2004 May;271(10):1980-90. Masson P, Goldstein BN, Debouzy JC, Froment MT, Lockridge O, Schopfer LM. Damped oscillatory hysteretic behaviour of butyrylcholinesterase with benzoylcholine as substrate. Eur J Biochem. 2004 Jan;271(1):220-34. Boeck AT, Schopfer LM, Lockridge O. DNA sequence of butyrylcholinesterase from the rat: expression of the protein and characterization of the properties of rat butyrylcholinesterase. Biochem Pharmacol. 2002 Jun 15;63(12):2101-10. Josse D, Lockridge O, Xie W, Bartels CF, Schopfer LM, Masson P. The active site of human paraoxonase (PON1). J Appl Toxicol. 2001 Dec;21 Suppl 1:S7-11. Masson P, Schopfer LM, Bartels CF, Froment MT, Ribes F, Nachon F, Lockridge O. Substrate activation in acetylcholinesterase induced by low pH or mutation in the pi-cation subsite. Biochim Biophys Acta. 2002 Feb 11;1594(2):313-24. Duysen EG, Li B, Xie W, Schopfer LM, Anderson RS, Broomfield CA, Lockridge O. Evidence for nonacetylcholinesterase targets of organophosphorus nerve agent: supersensitivity of acetylcholinesterase knockout mouse to VX lethality. J Pharmacol Exp Ther. 2001 Nov;299(2):528-35. Sun H, El Yazal J, Lockridge O, Schopfer LM, Brimijoin S, Pang YP. Predicted Michaelis-Menten complexes of cocaine-butyrylcholinesterase. Engineering effective butyrylcholinesterase mutants for cocaine detoxication. J Biol Chem. 2001 Mar 23;276(12):9330-6. Epub 2000 Dec 4. Li B, Stribley JA, Ticu A, Xie W, Schopfer LM, Hammond P, Brimijoin S, Hinrichs SH, Lockridge O. Abundant tissue butyrylcholinesterase and its possible function in the acetylcholinesterase knockout mouse. J Neurochem. 2000 Sep;75(3):1320-31. Bartels CF, Xie W, Miller-Lindholm AK, Schopfer LM, Lockridge O. Determination of the DNA sequences of acetylcholinesterase and butyrylcholinesterase from cat and demonstration of the existence of both in cat plasma. Biochem Pharmacol. 2000 Aug 15;60(4):479-87. Josse D, Xie W, Masson P, Schopfer LM, Lockridge O. Tryptophan residue(s) as major components of the human serum paraoxonase active site. Chem Biol Interact. 1999 May 14;119-120:79-84. Josse D, Xie W, Renault F, Rochu D, Schopfer LM, Masson P, Lockridge O. Identification of residues essential for human paraoxonase (PON1) arylesterase/organophosphatase activities. Biochemistry. 1999 Mar 2;38(9):2816-25. Masson P, Legrand P, Bartels CF, Froment MT, Schopfer LM, Lockridge O. Role of aspartate 70 and tryptophan 82 in binding of succinyldithiocholine to human butyrylcholinesterase. Biochemistry. 1997 Feb 25;36(8):2266-77. PubMed Search |
