Associate Professor, Eppley Institute
Education
Ph.D., University of Vermont
Research Interests
Chemical probes for protein-protein interactions
Summary of Research
Phosphorylation and de-phosphorylation reactions of cellular proteins are ubiquitous in nature and represent the molecular on/off switch that triggers innumerable signaling events mediated by phospho-specific protein-protein interactions. Our research interest focuses on the use of small molecules to perturb these phospho-specific protein-protein interactions as a first step towards understanding how cells exploit these interactions in signal transduction. Chemical probes for this effort are derived from natural products and the design of conformationally constrained mimics. Synthetic chemistry spearheads the research program, however, biology and computational methods are used synergistically in our quest for a better comprehension of the cellular events contiguous to phospho-specific protein-protein interactions.
Group Pictures
Spring 2012
Fall 2011
Fall 2010
Summer 2010
Winter 2009
Fall 2009
Fall 2008
2006
2005
Amar Natarajan, Ph.D.
Phone: 402-559 3793
Email: Amar Natarajan
