Amar Natarajan, Ph.D.

Associate Professor, Eppley Institute

Education

Ph.D., University of Vermont

Research Interests

Chemical probes for protein-protein interactions  

Summary of Research

Phosphorylation and dephosphorylation reactions of cellular proteins are ubiquitous in nature and represent the molecular on/off switch that triggers innumerable signaling events mediated by phospho-specific protein-protein interactions. Our research interest focuses on the use of small molecules to perturb these phospho-specific protein-protein interactions as a first step towards understanding how cells exploit these interactions in signal transduction. Chemical probes for this effort are derived from natural products and the design of conformationally constrained mimics. Synthetic chemistry spearheads the research program, however, biology and computational methods are used synergistically in our quest for a better comprehension of the cellular events contiguous to phospho-specific protein-protein interactions.

Targeting the phosphoprotein binding site on BRCT(BRCA1)/Cbl(TKB)

Assay development and high throughput screening

Computational studies

Methods development, synthesis of focused libraries and natural product syntheses

Selected Publications

Group Pictures

Spring 2012

Spring 2012

Fall 2011

Fall 2011

Fall 2010

Fall 2010

Summer 2010

Summer 2010

Winter 2009

Winter 2009

Fall 2009

Fall 2009

Fall 2008

Fall 2008

2006

2006

2005

2005

 

Amar Natarajan, Ph.D.
Dr. Natarajan

Phone:  402-559 3793
Email: Amar Natarajan

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