The principal goal of the Developmental Research Program is to fund promising early stage projects that address important translational objectives in prevention, early detection, and therapy of pancreatic carcinoma. Our principal intent for the Developmental Research Program is to bring novel translational research projects to the SPORE program. Key elements that determine priority in this program are innovation, novelty, and potential for success in translational pancreatic cancer research. All Developmental Funds will be awarded by competition based on submission of a NIH-style pilot project application. There is a requirement for clear evidence that the proposed project shows potential of developing into a larger research project that will involve human intervention for pancreatic cancer (diagnostic or therapeutic).
| PI | Title |
| Seven projects were funded for 2011-2012: | |
| Michael Brattain, Ph.D. & Quan Ly, MD | Pre-clinical Development of Novel Therapies for Pancreatic Cancer (Year 2) |
| Michael A. Hollingsworth, Ph.D. | Inhibition of CDK5 as a treatment for pancreatic cancer (Year 2) |
| Amar Natarajan, Ph.D. | Define the disease state of IKKb and develop small molecule inhibitors against it for pancreatic cancer therapy |
| Polina Shcherbakova, Ph.D. | Prevalence of DNA Polymerase δ Mutations in Colorectal Cancer |
| Simon Sherman, Ph.D. | Prognostic Tools for Pancreatic Cancer Survival |
| Pankaj Singh, Ph.D. | A metabolic approach for targeting gemcitabine resistance in pancreatic cancer |
| Jenny Wang, Ph.D. | Unique Role of HIF1α in Colon Cancer Metastasis |
| Five projects were recently funded in response to the 2010 DRP RFA. | |
| Michael Brattain, Ph.D. | Pre-clinical Development of Novel Therapies for Pancreatic Cancer |
| David Berkowitz, Ph.D. (UNL) | A Novel Podophyllum Lignan-based Approach to Therapeutics for Pancreatic Cancer |
| Michael A. Hollingsworth, Ph.D. | Inhibition of CDK5 as a treatment for pancreatic cancer |
| Joyce Solheim, Ph.D. | Strategies to Decrease Immune Evasion and Growth of Pancreatic Cancer Cells |
| Vimla Band, Ph.D. | Ecd as a regulator of cell cycle and pancreatic oncogenesis |
