Molecular and Cellular Biology of Ocular Development and Diseases
Signal Transduction Pathways in Ocular Development and Diseases, and Cancer
Dr. Li’s lab uses the state-of-the-art molecular and cellular biology techniques, imaging technology, transgenic mice and zebrafish in vivo system, organ culture, primary culture and established cell line in vitro systems to explore functional mechanisms of the protein serine/threonine phosphatases-1 and -2A, the mitogen-activated protein kinases, the small heat shock proteins, alpha-crystallins, and small ubiquitin-like modifiers (SUMO1/2/3) in regulating development of the ocular system components (lens and retina), pathogenesis and treatment of the major ocular diseases (cataractogenesis, macular degeneration, and glaucoma, etc). Dr. Li’s laboratory also studies the roles of Pax-6, PP-2A and alphaA-crystallin in cancer development and treatment.
B.Sc., Hunan Normal University, Changsha, Hunan, China
M.Sc., Hunan Normal University, Changsha, Hunan, China
Ph.D., University of Washington, Seattle, WA, USA
Columbia University Medical Center in New York City, NY, USA