Research Interests: Blood brain barrier and neural development in premature infants and neuroimmunology of multiple sclerosis. Research Summary: Recent or key Bibliographical Citations: Leuschen MP and Amato RS. The role of cyclic nucleotide in the regulation of mitotic activity in SSPE virus infected human brain tissue. Exp Cell Res 114:79-84, 1978. Leuschen MP, Shuman RM and Nelson RM The development of capillaries in the telencephalon of beagle puppies. Anatomical Record 208(5):435-443, 1984. Nelson RM, Leuschen MP, Kasik JW and Shuman RM Effect of phenobarbital on intraventricular hemorrhage in asphyxiated newborn beagles. J of Perinatology, Vol V(2):16-20, 1985. Leuschen MP and Nelson RM Telencephalic microvessels of premature beagle pups. Anatomical Record. 215: 59-64, 1986. Leuschen MP and Nelson RM Effects of asphyxia on telencephalic microvessels of premature Beagle pups. J Perinatology 8(2):93-99, 1987. Leuschen MP, Nelson RM. Vasoconstriction in telencephalic microvessels: A response to one model for intraventricular hemorrhage in Beagle pups. Anatomic Record 224:534-540, 1989. Thakran P, Leuschen MP, Ebadi M Metallothionein induction in rat hippocampal neurons in primary culture. IN VIVO 3:190-198, 1989. Leuschen MP, Wolf LJ, Rayburn WF Excretion of fentanyl citrate in breast milk. Letter to Ed. Clin Pharm 9(5):336-337, 1990. Leuschen MP, Ehrenfried JA, Willett LD, Schroder KA, Bussey ME, Bolam DL, Goodrich PD, Nelson RM. Prostacyclin levels during and following neonatal extracorporeal membrane oxygenation. J Thoracic Cardiovasc Surg, 199: 148-152, 1991. Leuschen MP, Willett LD, Bolam DL, Eggert LD, Nelson RM. Plasma ß-endorphin in neonates: Effect of prematurity, gender and respiratory status. J Clin Endocrin Metab 73(3): 1062-1066, 1991. Hill LD, Sun L, Leuschen MP, Zach TL. C3 synthesis by A549 Alveolar Epithelial cells is increased by Interferon-gamma and dexamethasone. Immunology 79:236-240, 1993. Ebadi M, Leuschen MP El Rafaey H, Hamada FM, Rojas P The antioxidant properties of zinc and metallothionein. Neurochem Int. 29(2): 159-166, 1996. Moore, CT and MP Leuschen. Synaptic Density in the arcuate nucleus of female rats approaching middle age. Neurosci Ltrs 254(2): 73-76, 1998. Elliott, C, El-Touny, S., Filip, M.L., Healey, KM., Leuschen, MP, Interferon ß1a treatment modulates Th 1 expression in gamma delta ? + T cells from relapsing remitting multiple sclerosis patients. J. Clin Immunol 21: 200-209, 2001. Miller, DH, Khan OA, Sheremata WA, Blumhard LD, Rice GP, et. al. International Natalizumab Multiple Sclerosis Trial Group. A controlled trial of natalizumab for relapsing multiple sclerosis. N. Engl. J. Med. 348(1): 15-23, 2003. Healey KM,Pavletic SZ, Al-Omaishi J, Leuschen MP, Pirruccello SJ, Filipi ML, Enke C, Ursick MM, Hahn F, Bower JD, Nash RA. Discordant functional and inflammatory parameters in multiple sclerosis patients after autologous haematopoietic stem cell transplantation. Multiple Sclerosis 2004: 10: 284-298. Leuschen MP, FIlipi M Healey KM, A Randomized open label study of pain medications (naproxene, acetaminophen and ibuprofen) for controlling side effects during initiation of IFN-ß-1a therapy and during its ongoing use for relapsing remitting multiple sclerosis. Multiple Sclerosis 2004: 10: 636-642. Book Chapters: |
