Professor
PhD - Columbia University 1988
Phone: 402-559-8891
Fax: 402-559-7328
Email: rnorgren@unmc.edu
URL: Lab webpage
Teaching:
- 20 years experience teaching Neuroscience to medical students
- Co-Director of the M1 Neuroscience Core, 2000-2002
- M1 Golden Apple Award, 1995
- M1 Golden Apple Award, 1997
- Alvin Earle Outstanding Health Science Educator Award, 2001
Research:
Dr. Norgren is the Director of a project funded by the National Center for Research Resources and the Office of Research Infrastructure Programs (ORIP) of the National Institutes of Health. His research is currently focused on the use of nonhuman primate genomics to better understand human genetic disease. Methods include Next Generation Sequencing and Bioinformatics. Work in the Norgren Laboratory resulted in a novel approach to the production of the Rhesus Macaque GeneChip, a device for measuring the expression of tens of thousands of genes at the same time. You can read more about how the rhesus genechip was invented here: "Novel approach results in first-ever rhesus macaque whole-genome array". Ongoing projects include a new assembly of the rhesus genome using NextGen sequencing and SNP discovery. This work was recently highlighted in the cover story for the November issue of Genome Technology: 'The Other Primates'. For more information on current research in the Norgren Lab check out the Lab webpage.
Honors:
- Research Career Development Award (KO4), The National Institutes of Health, 1995
- Distinguished Scientist Award, University of Nebraska Medical Center, 2008
Recent Talks:
- De novo assembly of the rhesus macaque transcriptome from NextGen mRNA sequences
Fifth International Conference on Primate Genomics at Houston TX, April 19th 2012 -
Rhesus macaque genomics
Nebraska Center for Virology, University of Nebraska at Lincoln, April 6, 2012 - Limitations of Automated Annotation Software When Used with Draft Genomic Assemblies
9th Annual Rocky Mountain Bioinformatics Conference, December 9th 2011
Review Article
-
Norgren, R. B. (2012) Using NextGen sequencing to identify the molecular basis for genetic disease: an evolutionary perspective. Methods in Next Generation Sequencing. 1: 1-9.
Research Publications:
- Nonhuman primate genomics
- Zhang, X., Goodsell, J. and Norgren R. B. (2012) Limitations of the rhesus macaque draft genome assembly and annotation. BMC Genomics, 13:206
- Duan, F. Pauley, M. A., Spindel, E. R., Zhang, L. and Norgren R. B. (2010) Large scale analysis of positional effects of single-base mismatches on microarray gene expression data. BioData Mining, 3:2
- Duan, F., Spindel, E.R., Li, Y-H and Norgren, R.B. (2007) Intercenter reliability and validity of the rhesus macaque GeneChip. BMC Genomics, 8:61.
- Ferguson, B., Street, S.L., Wright, H., Pearson, C., Jia, Y., Thompson, S.L., Allibone, P., Dubay, C.J., Spindel, E. and Norgren, R.B. (2007) Single nucleotide polymorphisms (SNPs) distinguish Indian-origin and Chinese-origin rhesus macaques (Macaca mulatta). BMC Genomics, 8:44.
- Norgren, R.B. Expression arrays for macaque monkeys. (2006) Transplantation Reviews, 20: 115-120.
- Spindel, E.R., Pauley, M.A., Jia,Y., Gravett, C.,Thompson, S., Boyle, N., Ojeda, S.R., and Norgren, R.B. (2005) Leveraging human genomic information to identify nonhuman primate sequences for expression array development, BMC Genomics, 6:160.
- Zhang, X., Goodsell, J. and Norgren R. B. (2012) Limitations of the rhesus macaque draft genome assembly and annotation. BMC Genomics, 13:206
- Nonhuman primate genetics
- Meehan, D.T., Zink, M.A., Mahlen, M., Nelson, M., Sanger, W.G., Mitalipov, S.M., Wolf, D.P., Ouellettte, M.M., Norgren, R.B. (2008) Gene targeting in adult rhesus macaque fibroblasts. BMC Biotechnol, 8:31.
- Norgren, R.B. (2006) Genetic modification of somatic cells for producing animal models and re-engineering of cells for transplantation. Reproduction, Fertility and Development, 20: 115-120.
