John G. Sharp, Ph.D.

Professor

John G. Sharp, Ph.D.University of Birmingham (England)
1971

Phone: 402-559-4390
Fax: 402-559-3400
Email: jsharp@unmc.edu

National/International Committees:

  • Chair, NIH/NHLBI Expert Panel. Product Assistance for Cellular Therapy (PACT) Program 2011-2016
  • Ad hoc member, various NCI and other NIH Review Committees
  • Reviewer: Musculoskeletal Transplantation Foundation (MTF) and Oak Ridge Associated Universities and Pennsylvania Department of Health

 UNMC Committees:

  • Chair, Human Embryonic Stem Cell Scientific Review Committee (ESCRO)

Teaching: Dr. Sharp lectures in several service and graduate student courses and the UNMC High School Alliance Program 

Research: Stem cell biology, basic and translational science applications of stem cells. Regulation of self-renewal versus differentiation of stem cells of normal tissues and tumors. Reprogramming and applications of stem cells for therapy. Role of stem cells in aging and interventions to promote healthy aging. 

Keywords: Stem cells: hematopoietic, mesenchymal, endothelial, lung, liver, intestinal, bone, adipose tissue. SP stem cells, cellular therapy, tissue repair, physical activity/exercise, regeneration and aging 

Publications listed in PubMed

Recent Publications:

  1. Sharp JG, Jackson JD. Hematopoietic stem cells and cytokines. “Atlas of Clinical Hematology”, Current Medicine Philadelphia 2nd Ed., J.O. Armitage Ed., Chapter 7, 2007.
  2. Brusnahan SK, McGuire TR, Jackson JD, Lane JT, Garvin KL, O'Kane BJ, Berger AM, Tuljapurkar SR, Kessinger MA, Sharp JG. Human blood and marrow side population stem cell and Stro-1 positive bone marrow stromal cell numbers decline with age, with an increase in quality of surviving stem cells: correlation with cytokines. Mech Ageing Dev. 2010 Nov-Dec;131(11-12):718-22. Epub 2010 Oct 28.
  3. Togo S, Sato T, Sugiura H, Wang X, Basma H, Nelson A, Liu X, Bargar TW, Sharp JG, Rennard SI. Differentiation of embryonic stem cells into fibroblast-like cells in three-dimensional type I collagen gel cultures. In Vitro Cell Dev Biol Anim. 2011 Feb;47(2):114-24. Epub 2010 Nov 25.
  4. Sato T, Liu X, Basma H, Togo S, Sugiura H, Nelson A, Nakanishi M, Kanaji N, Wang X, Kim M, Li Y, Michalski J, Farid M, Sharp JG, Rennard SI. IL-4 induces differentiation of human embryonic stem cells into fibrogenic fibroblast-like cells. J Allergy Clin Immunol. 2011 Jun;127(6):1595-603.e9. Epub 2011 Mar 8.
  5. McGuire TR, Brusnahan SK, Bilek LD, Jackson JD, Kessinger MA, Berger AM, Garvin KL, O'Kane BJ, Tuljapurkar SR, Sharp JG. Inflammation associated with obesity: relationship with blood and bone marrow endothelial cells. Obesity (Silver Spring). 2011 Nov;19(11):2130-6. doi: 10.1038/oby.2011.246. Epub 2011 Sep 8.
  6. Tuljapurkar SR, McGuire TR, Brusnahan SK, Jackson JD, Garvin KL, Kessinger MA, Lane JT, O' Kane BJ, Sharp JG. Changes in human bone marrow fat content associated with changes in hematopoietic stem cell numbers and cytokine levels with aging. J Anat. 2011 Nov;219(5):574-81. doi: 10.1111/j.1469-7580.2011.01423.x. Epub 2011 Sep 16.
  7. Fereydoon Namavar, Alexander Rubinstein, Renat F. Sabirianov, Geoffrey M. Thiele, John G. Sharp, Utsav Pokharel, Roxanna M. Namavar, Hani Haider and Kevin L. Garvin. Engineered nanostructured coatings for enhanced protein adhesion and cell growth. 2011 MRS Fall Meeting proceedings, Cambridge Journals Online
  8. Hegde GV, Nordgren TM, Munger CM, Mittal AK, Bierman PJ, Weisenburger DD, Vose JM, Sharp JG, Joshi SS. Novel therapy for therapy-resistant mantle cell lymphoma: Multipronged approach with targeting of hedgehog signaling. Int J Cancer. 2012 Apr 17. doi: 10.1002/ijc.27602.
  9. Tuljapurkar SR, Jackson JD, Brusnahan SK, O’Kane BJ, Sharp JG. Characterization of a mesenchymal stem cell line that differentiates to bone and provides niches supporting mouse and human hematopoietic stem cells. Stem Cell Discovery, Vol 2, No 1, 5-14 (2012)
  10. Parameswaran S, Balasubramanian S, Babai N, DelDebbio CB, Harms DW, Gurumurthy CB, Rao MS, Sharp JG, Ahmad I. Nucleic acid and non-nucleic acid-based reprogramming of adult limbal progenitors to pluripotency (PLos ONE) (in press 2012)

 

Links

  • Stem cell biology research group

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