Research overview

Our research is in genomics. Analyzing life process at genome level provides systems information to understand normal physiology and to study diseases. The rapid development of genomics technologies is making revolutionary impact on biology and medicine. Our study is focused on the following topics: 

Transcriptome
Gene expression reflects biological activities of the genome under physiological or pathological conditions. We studied the transcriptome covering the area of annotating the transcribed regions in the human, Drosophila and rice genomes, analyzing normal gene expression in human hematopoiesis system, and abnormal gene expression in leukemia with chromosomal abnormalities, and identifying novel mutations in leukemia. 

Genome structure
Genetic abnormalities include insertion, deletion, amplification and translocation and SNPs. Comprehensive mapping these changes are essential to reveal the genetic basis of diseases. We are using the next-generation DNA sequencing technologies and bioinformatics to analysis of genome structure in inherited diseases and cancer genome. 

Genomics technology development
Genomics study relies heavily on the technologies with high-throughput capacity for information acquisition and the sophisticated computational tools for data analysis. We are developing next-generation DNA sequencing-based technologies for genome structural and transcriptome studies. We are also developing bioinformatics tools for genome data collection, analysis and interpretation.

Lab Members
San Ming Wang, Associate Professor
Yeong C. Kim, Assistant Professor
Bradley Downs, Graduate Student
Fengxia Xiao, Graduate Student

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