Human Genetics Laboratory

TEL [12p13]
Hyperdiploidy
BCR/ABL [t(9;22)] / LSI 9q34

MLL [11q23]

p16 [9p21]

Myelodysplastic Syndrome (MDS)
EGR-1 [5q31]
8CEP
7CEP / D7S486 [7q31]
BCR / ABL [t(9;22) / LSI 9q34]
MLL [11q23]

D20S108 [20q12]

Multiple Myeloma (MM)
D13S319 [13q14 / 13q34]
IgH translocation
      IgH/CCND1 [t(11;14)]
      IgH/FGFR [t(4;14)]
      IgH/MAF [t(14;16)]
p53 [17p13.1]

6q23
Hyperdiploidy [CEP 9/11, 15q22]

Acute Myeloid Leukemia (AML)
7CEP
8CEP

AF10 [10p12]

AF10 / PICALM [t(10;11)]
MLL [11q23]
ETO/AML1 [t(8;21)]
PML/RARA [t(15;17)]
CBFB [16q22]

Solid Tumor / LSG
Lymphoma Probes
ALK [(2p23) & variants]
IgH / MYC / 8CEP [t(8;14)]
IgH / CCND1 [t(11;14)]
IgH / BCL2 [t(14;18)]
IgH / MALT [t(14;18)]
IgH [14q32 abnormalities]
BCL6 [3q27]

CMYB [6q23]
CMYC [8q24]

CCND1 [11q13]
ETV6 [12p13]

TCR [14q11]
MALT1 [18q21 / t(11;18)]

BCL2 [18q21]

Gastric MALT Panel

MALT1 [18q21] / CEP18

IgH [14q32]

CEP3

Splenic Marginal Zone Panel

D75486 [7q31] / CEP7

MALT1 [18q21] / CEP18

CEP3

Sarcomas
Ewing - EWS [t(11;22) & variants]

Liposarcoma - LSI CHOP [12q13] / MDM2 [12q15]

FUS [16p11]

Dermatofibrosis Protuberans [t(17;22)]
Synovial - SYT [18q21 / t(X;18)]

Lipoma - HMGA2 [12q14]

Clear Cell - ATF1 / EWS [t(12;22)]

CREB3L2 / FUS [t(7;16)]

Carcinoma

NUT / BDR4 [t15;19) & NUT variants]

Breast Cancer
HER2/neu [17q12]

TOP2A [17q11.2-12]

Rhabdomyosarcoma
FKHR  [13q14]

PAX3 [2q35]

Neurological Cancer Probes
1p36 / 1q25
19q13 / 19p13

EGFR [7p12]

PTEN [10q23]