Section of General Surgery

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    • Matthew Goede, M.D.
    • Mark A. Carlson, M.D.
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(page under construction) 

The University of Nebraska Medical Center has established a consortium in Regenerative Medicine which addresses regeneration and tissue engineering in multiple areas (see link to Brochure below). As part of this consortium, the Carlson lab has been interested in the development of a dermal template for skin replacement therapy. This template consists of a 'smart matrix"—a biodegradable scaffold coated with naturally-occurring proteins of the extracellular matrix, in which are embedded dermal fibroblasts and mesenchymal stem cells. This scaffold is topped with a basal lamina, and then surfaced with keratinocytes. The aim of this project is to first characterize and optimize the engineered skin equivalent in animal models, and then move into clinical testing. This skin replacement therapy would be applicable to both military and civilian patients who have suffered massive skin loss from burns, blast injury, or other trauma. 

2009 UNMC Brochure on Regenerative Medicine [pdf]