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A novel hemostatic bandage is being developed at UNMC in collaboration with investigators at the University of Nebraska Lincoln. This bandage consists of a nano-engineered biodegradable scaffold embedded with human recombinant clotting factors (fibrinogen, thrombin, and Factor XIII). Preliminary studies have indicated that this bandage will have the following characteristics: 

1. Efficacy: the bandage can stop hemorrhage from laceration of femoral artery in a large subject.
2. Biocompatibility: the 100% biodegradable bandage can be implanted and left in place, with no ill effects on the subject.
3. Safety: the use of recombinant proteins minimizes risk of blood-borne pathogens.
4. Pliability: the bandage will be soft & pliable, able to conform to irregular surfaces.
5. Utility: bandage will require no special training for use; simply apply & hold pressure.
6. Stability: bandage will be stable at room temperature for at least one year.
7. Economy: production of recombinant clotting factors will be relatively cheap compared to the cost of plasma-derived clotting factors.
8. Scalability: manufacture of all bandage components (including scaffold material and recombinant clotting factors) can be continuously scaled to meet market demands.
9. Compliance: individual components of the bandage are known quantities with no biohazard potential, so FDA approval of device should be uncomplicated.  

In addition, other uses for the human recombinant clotting factors are being developed, including a "fibrin glue" product (for use by surgeons in the operating room), and an intravenous infusion therapy for patients suffering from massive blood loss. All of these products will be extremely useful in both military and civilian settings.  

UNMC has produced a short (1 minute) video which provides a lay description of the hemostatic bandage (also known as the liquid bandage in the video). This video can be watched on YouTube, or it can be viewed directly in your browser. 

View video on YouTube 

Watch video in browser (to save, right-click and choose "save file as")