Story contributed by the Lymphoma Research Foundation
| New ways to attack an aggressive and incurable type of lymphoma will be studied at UNMC with the help of a $300,000 grant from the Lymphoma Research Foundation (LRF).
Kai Fu, M.D., Ph.D., associate professor of pathology and microbiology, has received the grant — called the 2009 Millennium Pharmaceuticals, Inc./Lymphoma Research Foundation Clinical Investigator Career Development Award — to support his mantle cell lymphoma research. This substantial investment by the Lymphoma Research Foundation is indicative of the group’s high esteem for Dr. Fu’s work, said Tom Rosenquist, Ph.D., vice chancellor for research at UNMC.
“I know that, with his innovative research approach and high level of energy, the investment will pay dividends in new, improved therapy for patients with mantle cell lymphoma,” he said.
Lymphoma — the most common type of blood cancer — is broadly categorized into Hodgkin’s lymphoma (HL) and non-Hodgkin’s lymphoma (NHL). According to the World Health Organization, there are six types of HL and more than 61 types of NHL.
Mantle cell lymphoma is a rare B-cell NHL that is very aggressive. It accounts for 6 percent of all new diagnoses of NHL — or about 3,000 new cases per year in the United States.
It is characterized by over expression of the gene called cyclin D1 due to a chromosomal translocation.
A subset of mantle cell lymphoma also shows higher levels of a group of small RNA molecules, called miR-17~92.
Dr. Fu and his colleagues have found that this higher expression correlates directly with poorer patient survival. These findings indicate that higher miR-17~92 expression induces abnormal activation of a pathway in tumor cells that leads to increased resistance to standard chemotherapy.
This recent award will help Dr. Fu conduct a pre-clinical study to determine whether suppression of miR-17~92 will improve the effect of chemotherapy. His study may lead to a novel approach to treat MCL patients.
“Dr. Fu’s elegant proposal explores a new avenue for understanding MCL and identifying potential therapeutic targets,” said Michael Williams, M.D., director of the University of Virginia’s Hematologic Malignancy Program and chairman of the LRF’s Mantle Cell Consortium, of which Dr. Fu also is a member. “We are delighted that Dr. Fu has chosen MCL as the focus of his Clinical Career Development Project.”
Date Published: Wednesday, August 12, 2009