UNMC INBRE Mentors-Genetics, Cell Biology & Anatomy

Vimla Band, Ph.D.
Ardith and Anna Von Housen
Professor and Chair
Associate Director of Center for Breast Cancer Research - Eppley Cancer Center
E-mail: vband@unmc.edu

Research Interests:  We have identified several new proteins that are involved in mammary epithelial cell transformation.  We are testing the roles of the those proteins in negative regulation of cell-matrix and cell-cell adhesion.  Mouse models are currently used to examine the role of these novel targets in epithelial cell growth, differentiation, development, and oncogenesis using both in vitro and in vivo (knock-out) approaches.  Furthermore, an important ongoing area of research is to examine the role of these novel proteins in breast and other carcinomas tumor progression by examining their expression and localization in human tumor tissues.

For more information on Dr. V. Band: Web Site

Andrew T. Dudley, PhD
Associate Professor
Holland Regenerative Medicine Program
Dept. of Genetics, Cell Biology and Anatomy
Email:  andrew.dudley@unmc.edu

Research in the Dudley Laboratory is focused on understanding the mechanisms of cartilage degeneration and on the development of tissue engineering and regenerative medicine approaches to treat cartilage and bone defects. To accomplish these goals, we study prenatal and postnatal development of model organisms to elucidate the molecular basis of tissue formation and then we apply this knowledge to the development of three-dimensional in vitro tissue systems to generate models to advance studies of disease mechanisms and cartilage regeneration. Current projects include studies of growth plate architecture and biomechanics, the origin of osteoarthritis, and the generation of full-thickness articular cartilage for transplantation.

For more information on Dr. V. Band: Web Site

Karen A. Gould, Ph.D.
Associate Professor
E-mail: kagould@unmc.edu

Research Interests:  The research in my lab is focused on understanding how genes and hormones impact our risk of developing certain diseases. One project seeks to understand how the hormone estrogen impacts the risk of developing lupus, an autoimmune disease that is ~10 times more common in women than men. We also study how the action of genetic factors that impact lupus risk are influenced by estrogens. A second project focuses on determining the role of genetic factors and estrogens in the risk of colon cancer, which is more common in men than women. This research will not only enhance our understanding of how genes and hormones impact disease risk, but also has the potential to assist in the development of more effective prevention and treatment of these diseases. Toward this goal, my lab is currently investigating the use of targeted drug delivery systems to deliver hormone modulating drugs to treat these diseases.

For more information on Dr. Gould: Web Site 

Chittibabu (Babu) Guda, Ph.D.
Associate Professor
E-mail: babu.guda@unmc.edu

Research Interests: My laboratory nurtures a wide variety of research areas related to bioinformatics. Research topics can be broadly grouped under novel method development, data mining and knowledge discovery, and the application of machine learning tools to solve biological problems. In addition, we have been developing and supporting web servers and software tools for bioinformatic applications.

For more information on Dr. Guda: Web Site

 Shantaram Joshi, Ph.D.
E-mail: ssjoshi@unmc.edu

Research Interests:  Despite advances in treatment, leukemia and lymphoma are often fatal diseases in people.  Our laboratory research is concentrating on find out out in greater detail what changes occur at the molecular level in B-cell cancers of the immune system.  By determining what changes occur, especially in cells that become resistant to chemotherapy, we are trying to help design better therapy for patients.

For more information on Dr. Joshi: Web Site

Runqing Lu, Ph.D.
Associate Professor
E-mail: rlu@unmc.edu

Research Interests:  An active immune system depends on the development of the lymphocytes that secrete antibodies.  This requires a number of proteins, both inside and outside the lymphocytes.  We are looking at how internal transcription factors that control gene expression work together to promote and regulate the formation of active antibody-secreting B-lymphocytes.  This is being accomplished using mutant mice that have lost important proteins in this pathway and looking at how their lymphocytes are affected.

For more information on Dr. Lu: Web Site

San Ming Wang, M.D.
Associate Professor
E-mail: sanming.wang@unmc.edu

Research Interests:  My research is in genomics. The rapid progress of genomics science in recent years has made revolutionary impact on biology and medicine. Analyzing life process at genome level provides systems information to understand the basis of physiology and to study diseases. My research topics include the studies of transcriptome, which reflects biological activities of the genome under physiological or pathological conditions; the studies of genome structural abnormalities, which represent the genetic factors contributing to various diseases; and the development of next-generation DNA sequencing-based technologies and bioinformatics tools, which are required to analyze the high-complex genome. National Human Genome Research Institute and National Cancer Institute of National Institute of Health, the Department of Defense, and multiple private foundations have supported my studies.

For more information on Dr. Wang: Web Site