Cardiology

Brian Lowes. M.D., Ph.D.

William D. Angle Chair of Cardiology
Professor, Internal MedicineBrian Lowes, M.D., Ph.D.
Division of Cardiology

Academic Office:
Department of Internal Medicine
982265 Nebraska Medical Center
Omaha, NE 68198-2265
Phone (402)559-5151
Fax (402)559-8355

Practice Locations:
Durham Outpatient Center
For An Appointment Call (402)559-8888
Toll Free 1-800-97-HEART (1-800-974-3278)

Hospital Appointments:
The Nebraska Medical Center
Children's Hospital and Medical Center
Methodist Hospital

Board Certification:
Internal Medicine
Cardiovascular Medicine  

Education:

Wayne State University School of Medicine (Detroit, Ml)
Doctor of Medicine, 1989

University of Colorado Denver (Denver, CO)
Resident - Internal Medicine, 1992
Fellow - Heart Failure / Transplantation, 1993
Fellow - Cardiovascular Medicine, 1995
Ph.D. Clinical Science, 2011

Research Support:
R24 National Institutes of Health, Heart, Lung and Blood Institute, 2010 - 2015 "Novel Education Clinical Trainees and Education Program". The major goal of this proposal is to develop clinicians and scientist in sub-Saharan Africa

Selected Publications:
1. De Marco T, Wolfe! E, Feldman AM, Lowes BD, Higginbotham MB, Ghali JK, Wagoner L, Kirlin PC, Kennett JD, Goel S, Saxon LA, Boehmer JP, Mann D, Galle E, Ecklund F, Yong P, Bristow MR. Impact of cardiac resynchronization therapy on exercise performance, functional capacity,   and quality of life in systolic heart failure with QRS prolongation: COMPANION trial sub-study. J Card Fail. 2008 Feb;14(1):9-18.
2. Bergman BC, Tsvetkova T, Lowes BD, Wolfe! EE. Myocardial FFA metabolism during rest and atrial pacing in humans. Am J Physiol Endocrinol Metab. 2009 Feb;296(2).
3. Bergman BC, Tsvetkova T, Lowes B, Wolfel, Eugene E. Myocardial FFA metabolism during rest and atrial pacing in humans. American Journal of Physiology - Endocrinology & Metabolism. 296(2):E358-66, 2009 Feb.
4. Ambardekar AV, Lowes B, Cleveland JC, Brieke A, Overdrive pacing suppresses ectopy and minimizes left ventricular assist device suction events. Circulation: Heart Failure. 2(5):516-7, 2009 Sep.
5. Bristow MR, Murphy GA, Krause-Steinrauf H, Anderson JL, Carlquist JF, Thaneemit-Chen S, Krishnan V, Abraham WT, Lowes BD, Port JD, Davis GW, Lazzeroni LC, Robertson AD, Lavori PW, Liggett SB. An alpha2C-adrenergic receptor polymorphism alters the norepinephrine lowering effects and therapeutic response of the beta-blocker bucindolol in chronic heart failure. Circ Heart Fail. 2010 Jan;3(1):21-8.
6. Abraham, W. T., J. M. Aranda, J. P. Boehmer, U. Elkayam, E. M. Gilbert, S. S. Gottlieb, G. Hasenfut3, M. Kukin, B. D. Lowes, J. B. O'Connell, L. Tavazzi, A. M. Feldman, B. Ticho & C. Orlandi (2010) Rationale and Design of the Treatment of Hyponatremia Based on Lixivaptan in NYHA Class III/1V Cardiac Patient Evaluation (THE BALANCE) Study. Clin Trans! Sci, 3, 249-253.
7. Bristow, M. R., G. A. Murphy, H. Krause-Steinrauf, J. L. Anderson, J. F. Carlquist, S. Thaneemit¬Chen, V. Krishnan, W. T. Abraham, B. D. Lowes, J. D. Port, G. W. Davis, L. C. Lazzeroni, A. D. Robertson, P. W. Lavori & S. B. Liggett (2010) An alpha2C-adrenergic receptor polymorphism alters the norepinephrine lowering effects and therapeutic response of the beta-blocker bucindolol in chronic heart failure. Circ Heart Fail, 3,21-8.
8. Ambardekar, A. V., J. S. Walker, L. A. Walker, J. C. Cleveland, B. D. Lowes & P. M. Buttrick (2011) Incomplete Recovery of Myocyte Contractile Function Despite Improvement of Myocardial Architecture With Left Ventricular Assist Device Support. Circ Heart Fail.
9. Abraham, W. T., J. M. Aranda, J. P. Boehmer, U. Elkayam, E. M. Gilbert, S. S. Gottlieb, G. Hasenfuri, M. Kukin, B. D. Lowes, J. B. O'Connell, L. Tavazzi, A. M. Feldman, B. Ticho & C. Orlandi (2010) Rationale and Design of the Treatment of Hyponatremia Based on Lixivaptan in NYHA Class III/IV Cardiac Patient Evaluation (THE BALANCE) Study. Clin Trans! Sci, 3, 249-253.
10. Eckle, T., Hartmann, K., Mittelbronn M., Walker L, Lowes B.D., Buttrick P, Komminsky D., & Eltzschig H. The circadian rhythm protein Per2 mediates a metabolic switch critical for myocardial adaptation to ischemia Nature Medicine, In Press 2012.

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