Daniel R. Anderson, M.D., Ph.D
Assistant Professor
Division of Cardiology
Academic office:
Department of Internal Medicine
982265 Nebraska Medical Center
Omaha, NE 68198-2265
Practice Locations:
Omaha, Nebraska
Durham Outpatient Center
For An Appointment Call (402)559-8888
Toll Free 1-800-97-HEART (1-800-974-3278)
Hospital Appointments:
The Nebraska Medical Center
Omaha Veterans Administration Hospital
Board Certification:
Cardiovascular Medicine
Clinical Cardiac Electrophysiology
Education:
University of Nebraska Medical Center (Omaha, NE)
Doctorate of Philosophy, 1996
Doctor of Medicine, 1998
Resident - Internal Medicine, 2002
Fellow - Cardiovascular Disease, 2005
Fellow - Electrophysiology, 2006
Clinical Interests:
Cardiac electrophysiology: Cardiac Electrophysiology is the science of the mechanisms, functions, and performance of the electrical activities of specific regions of the heart. Dr. Anderson's specific clinical interests include understanding the aspects and contributing factors involved in atrial and ventricular arrhythmias, as well as in atherosclerosis and ischemic cardiomyopathy. Such arrhythmias are conditions in which the electrical activity of the heart is irregular, is faster or slower than normal and can be life threatening.
Research Interests:
Molecular and cellular immunology is the foundation of Dr. Anderson's research. Dr. Anderson has a specific focus and interest in innate immunity (preexisting immunity) and how such immune responses contribute to the mechanisms of cardiovascular disease processes. His studies have specifically focused on underlying mechanisms of viral myocarditis, atherosclerotic disease and the impact inflammation has on cardiac rhythm abnormalities. Recent studies have detailed the role of inflammation in arrhythmogenesis and atherosclerosis. Dr. Anderson has also detailed the utility of microbubble technology in the detection and monitoring of vascular inflammation.
Research Support:
American Heart Association - National Scientist Development Grant: 2007-2010
Title: Detection and Modulation of Vascular Inflammatory Events
The major goals of this research study were to evaluate the mechanisms of microbubble binding to injured endothelium, and the ability to non-invasively detect, image and monitor injured, inflamed, and dysfunctional endothelium.
American Heart Association - Grant-in-Aid: 2012 - 2014
Title: Protein Modification: Immune Sensitization, Cytotoxicity and Cardiovascular Disease
The major goal of this research study is to evaluate the innate immunology of vascular injury and specifically the impact of modified proteins in the development, progression, and prediction of atherosclerotic disease.
NIH Loan Repayment Award: 2007-2009
Selected Publications:
1. Anderson DR, Wilson JE, Carthy C, Yang DC, Kandolf R, McManus BM. Direct interactions of coxsackievirus B3 with immune cells in the splenic compartment of mice susceptible or resistant to myocarditis. J Virol 70:4632-4645, 1996.
2. Yang DC, Wilson JE, Anderson DR, Bohunek L, Cordeiro C, Kandolf R, McManus BM. In vitro mutational and inhibitory analysis of the cis-acting translational elements within the 5' untranslated region of coxsackievirus B3: Potential targets for antiviral action of antisense oligomer. Virology 228:63-73, 1997.
3. Anderson DR, Carthy CM, Wilson JE, Yang DC, Devine DV, McManus BM. Complement component 3 (C3) interactions with coxsackievirus B3 capsid proteins: Innate immunity and the rapid formation of splenic antiviral germinal centers. J Virol 71:8841-8845, 1997.
4. Carthy CM, Yang D, Anderson DR, Wilson JE, McManus BM. Myocarditis as systemic disease: New perspectives on pathogenesis. Clin Exp Pharmacol Physiol 24:997-1003, 1997.
5. Carthy CM, Granville DJ, Watson KA, Anderson DR, Wilson JE, Yang D, Hunt DW, McManus BM. Caspase activation and specific cleavage of substrates following coxsackievirus B3 —induced cytopathic effect in HeLa cells. J Virol 72:7669-7675, 1998.
6. Yang D, Cheung P, Sun Y, Yuan J, Zhang H, Carthy CM, Anderson DR, Bohunek L, Wilson JE, McManus BM. A Shine-Dalgarno-like sequence mediates in vitro ribosomal internal entry and subsequent scanning for translation initiation of coxsackievirus B3 RNA. Virology 305:31-43, 2003.
7. Anderson D, Tsutsui J, Xie F, Radio, S, Porter T. The Role of Complement in the Adherence of Microbubbles to Dysfunctional Arterial Endothelium and Atherosclerotic Plaque. Cardiovascular Research 73:597-606, 2007.
9. Duryee MJ, Klassen L, Schaffert C, Tuma DJ, Hunter CD, Garvin RP, Anderson DR, Thiele G. Malondialdehyde-Acetaldehyde adduct (MAA)
is the dominant epitope following MDA modification of proteins in atherosclerosis. Free Radic Biol Med 49:1480-6; 2010.
10.Anderson DR, Duryee MJ, Anchan RK, Garvin RP, Johnston MD, Porter TR, Thiele GM, Klassen LW. Albumin based microbubbles bind to upregulated scavenger receptors. J Biol Chem 285:40645-40653; 2010.
11 Anderson DR, Fletcher D, Scherschel J, Easley A. Pacemaker induced inappropriate ICD shock: An unusual case of ventricular tachycardia induction. Heart Rhythm 8:328-330;2011.
12.Anderson DR, Duryee, MJ, Garvin RP, Boska, MD, Thiele GM, Klassen LW. A Method for the Making and Utility of Gadolinium-labeled Albumin Microbubbles. Magnetic Resonance Imaging 30: 96-103; 2012.
13.Khaleel MS, Dorheim TA, Duryee MJ, Durbin HE, Bussey WD, Garvin RP, Klassen LW, Thiele GM, Anderson DR. High Pressure Distention of the Saphenous Vein During Preparation Results in Increased Markers of Inflammation: A Potential Mechanism for Graft Failure. Ann Thorac Surg 93(2): 552-8; 2012. PMCID in Progress
14.Koepsell S, Anderson DR, Radio S. Parvovirus B19 is a Bystander in Adult Myocarditis. Cardiovascular Pathology. http://dx.doi.org/10.1016/j.carpath.2012.02.002.
15.Thiele GM, Duryee MJ, Dusad A, Lacy JP, Anderson DR, Wang D, O'Dell JR, Mikuls TR, Klassen LW. Citrullinated mouse collagen administered to DBA/IJ mice in the absence of adjuvant initiates arthritis. In press - International lmmunopharmacology. DOI: 10.1016/j.intimp.2012.05.007.
16.Garvin RP, Duryee MJ, Klassen L, Thiele G, Anderson DR. Ultrasound Imaging in an Animal Model of Vascular Inflammation following Balloon Injury. Ultrasound in Medicine and Biology. DOI: 10.1016/j.ultrasmedbio.2012.05.011
17.Anderson DR, Gillberg J, Torrey J, Koneru J. Lightning induced inappropriate ICD shock: An unusual case of electromagnetic interference. PACE. 35:e159-e162;2012.
