Daniel R. Anderson, M.D., Ph.D
Assistant Professor
Division of Cardiology
Academic office:
Department of Internal Medicine
982265 Nebraska Medical Center
Omaha, NE 68198-2265
Practice Locations:
Omaha, Nebraska
UNMC Durham Outpatient Center
For All Appointments Call (402)559-8888
Toll Free 1-800-97-HEART (1-800-974-3278)
Education:
University of Nebraska Medical Center
Doctorate of Philosophy, 1996
Doctor of Medicine, 1998
Resident - Internal Medicine, 2002
Fellow - Cardiovascular Disease, 2005
Fellow - Electrophysiology, 2006
Clinical Expertise:
Cardiac electrophysiology: Cardiac Electrophysiology is the science of the mechanisms, functions, and performance of the electrical activities of specific regions of the heart. Dr. Anderson's specific clinical interests include understanding the aspects and contributing factors involved in both atrial and ventricular arrhythmias. Such arrhythmias are conditions in which the electrical activity of the heart is irregular or is faster or slower than normal.
Research Expertise:
Molecular and cellular immunology is the foundation of Dr. Anderson's research. Dr. Anderson has a specific focus and interest in innate immunity (preexisting immunity) and how such immune responses contribute to the mechanisms of cardiovascular disease processes. His studies have specifically focused on underlying mechanisms of viral myocarditis and atherosclerotic disease. Recent studies have detailed the role of inflammation in atherosclerosis and the utility of microbubble technology in the detection and monitoring of vascular inflammation.
Research Support:
National Scientist Development Grant: American Heart Association: 2007-2010
"Detection and Modulation of Vascular Inflammatory Events"
The major goals of this project are to evaluate the mechanisms of microbubble binding to injured endothelium, and the ability to non-invasively detect, image and monitor injured, inflamed, and dysfunctional endothelium.
Selected Publications:
- Anderson DR, Wilson JE, Carthy C, Yang DC, Kandolf R, McManus BM. Direct interactions of coxsackievirus B3 with immune cells in the splenic compartment of mice susceptible or resistant to myocarditis. J Virol 70:4632-4645, 1996.
- Yang DC, Wilson JE, Anderson DR, Bohunek L, Cordeiro C, Kandolf R, McManus BM. In vitro mutational and inhibitory analysis of the cis-acting translational elements within the 5' untranslated region of coxsackievirus B3: Potential targets for antiviral action of antisense oligomer. Virology 228:63-73, 1997.
- Anderson DR, Carthy CM, Wilson JE, Yang DC, Devine DV, McManus BM. Complement component 3 (C3) interactions with coxsackievirus B3 capsid proteins: Innate immunity and the rapid formation of splenic antiviral germinal centers. J Virol 71:8841-8845, 1997.
- Carthy CM, Yang D, Anderson DR, Wilson JE, McManus BM. Myocarditis as systemic disease: New perspectives on pathogenesis. Clin Exp Pharmacol Physiol 24:997-1003, 1997.
- Carthy CM, Granville DJ, Watson KA, Anderson DR, Wilson JE, Yang D, Hunt DW, McManus BM. Caspase activation and specific cleavage of substrates following coxsackievirus B3- induced cytopathic effect in HeLa cells. J Virol 72:7669-7675, 1998.
- Yang D, Cheung P, Sun Y, Yuan J, Zhang H, Carthy CM, Anderson DR, Bohunek L, Wilson JE, McManus BM. A Shine-Dalgarno-like sequence mediates in vitro ribosomal internal entry and subsequent scanning for translation initiation of coxsackievirus B3 RNA. Virology 305:31-43, 2003.
- Anderson D, Tsutsui J, Xie F, Radio, S, Porter T. The Role of Complement in the Adherence of Microbubbles to Dysfunctional Arterial Endothelium and Atherosclerotic Plaque. Cardiovascular Research 73:597-606, 2007.
