Cardiology

Cardiology Research Opportunities

Thomas Porter, MD

  1. Clinical trials examining the incremental benefit of real time myocardial perfusion imaging with myocardial contrast echocardiography. This is funded by Bristol Myers Squibb Medical Imaging and is a prospective randomized trial involving 3000 patients.
  2. Utility of quantitative assessments of systolic function by Magnetic Resonance Imaging in detecting early cardiac toxicity in the treatment of Large B-Cell Lymphoma. Dr. Matt Lunning is working with us on this project, but there is great potential for expansion into assessing the protective effects of carvedilol in preventing cardiotoxicity in Breast CA.
  3. Examining Synovial Perfusion and Inflammation in Rheumatoid Arthritis with Intravenous Perfluorocarbon Albumin Microbubbles. (Collaborative Effort with Rheumatology).
  4. Pre-Clinical Trials
    1. Utilization of intravenous targeted microbubbles and diagnostic ultrasound transducers to recanalize acute coronary thromboses. (NIH submission January 23, 2008).
    2. Utilization of intravenous microbubbles and transcranial ultrasound to transiently alter blood brain barrier. Funded NIH STTR grant: Start Date October 1, 2007.

CryoFACTs Trial: CryoCath Freezor CryoAblation Catheter System

  • Principal Investigator: Arthur Easley, MD
  • Granting Agency: CryoCath Technologies, Inc

Detection and Modulation of Vascular Inflammatory Events

  • Principal Investigator: Daniel R. Anderson, MD, PhD
  • Granting Agency: National American Heart Association

OPTIMUM Lead Insulation Material Registry

  • Principal Investigator: Daniel R. Anderson, MD, PhD
  • Granting Agency: St. Jude Medical

DEfibrillators To REduce Risk by MagnetIc ResoNance Imaging Evaluation (DETERMINE)

  • Principal Investigator: Daniel R. Anderson, MD, PhD
  • Granting Agency: St. Jude Medical

Role of Innate Inflammatory mediators in Acute Myocardial Infarction

  • Principal Investigator: Daniel R. Anderson, MD, PhD
  • Granting Agency: None

Role of Intravenous PESDA in Modulating Complement-Mediated Reperfusion Injury; 2) Detection and Monitoring of Vascular Inflammatory Events

  • Principal Investigator: Daniel R. Anderson, MD, PhD
  • Granting Agency: AHA

Placement of Coronary Sinus/Left Ventricular Pacing Leads with Endocardial Solutions, Incorporated Nav-X Guidance Protocol.

  • Principal Investigator: Christopher Erickson, MD
  • Granting Agency: St Jude Medical, Endocardial Solutions

Microbubble Potentiated Ultrasound as a New Method of Declotting Thrombosed Dialysis Grafts and Examination of the Effect of Ultrasound Attenuation on Thrombus Dissolution

  • Principal Investigator: Thomas R. Porter, MD
  • Granting Agency: NuVox Pharma

Sonothrombolysis of Vascular Clots with Targeted Bubbles

  • Principal Investigator: Thomas R. Porter, MD
  • Granting Agency: NuVox Pharma

Targeted Blood Brain Barrier Permeability Changes with Ultrasound and Microbubbles

  • Principal Investigator: Thomas R. Porter, MD
  • Granting Agency: National Institutes of Health

The Definity Real Time Perfusion During Dobutamine stress Echo Database

  • Principal Investigator: Thomas R. Porter, MD
  • Granting Agency: Lantheus Medical Imaging

Regadenoson Real Time Perfusion Study

  • Principal Investigator: Thomas R. Porter, MD
  • Granting Agency: Astellas Pharma Inc

Advancing Academic and Community Practices Through IAIMS

  • Principal Investigator: John R. Windle, MD
  • Granting Agencies: DHHS/NIH/National Library of Med

Sonolysis in Acute Coronary Syndromes

  • Principal Investigator: Feng Xie, MD
  • Granting Agency: NIH

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