Pulmonary, Critical Care, Sleep & Allergy


[Publications from the last 3 years]

  1. A. Fernandez-Gonzalez, T. A. Wyatt, Stella Kourembanasand S. Alex Mitsialis. Mutation of evolutionarily conserved adenylate kinase underlies primary ciliary dyskinesia in mice. Am J Resp Cell Mol Biol 40:305-313, 2009.
  2. Oldenburg, P. J., T. A. Wyatt, P. H. Factor, and J. H. Sisson. Alcohol Feeding Blocks Methacholine-induced Airway Responsiveness in Mice. Am J. Physiol. 296:L109-114, 2009.
  3. Bailey, K. L., T. A. Wyatt, D. J. Romberger, and J. H. Sisson. Alcohol functionally upregulates Toll-like receptor 2 in airway epithelial cells. Alcoholism Clin Exp Res 33:495-504, 2009.
  4. Sisson, J. H., J. A. Pavlik, J. Buck, L. R. Levin, and T. A. Wyatt. Alcohol stimulates ciliary motility of isolated airway axonemes through a nitric oxide, cyclase and cyclic nucleotide-dependent kinase mechanism. Alcoholism Clin Exp Res 33:610-616, 2009.
  5. D. S. Allen-Gipson, J. C. Jarrell, J. H. Sisson, and T. A. Wyatt. Ethanol Blocks Adenosine Uptake via Inhibiting the Nucleoside Transport System in Bronchial Epithelial Cells. Alcoholism Clin Exp Res 33:791-798, 2009.
  6. Shao, C. H., S. Parbhu, X. Wehrens, T. A. Wyatt, G. J. Rozanski, K. P. Patel, and K. R. Bidasee. Exercise training during diabetes blunts cardiac ryanodine receptor dysregulation. J Applied Physiol. 106:1280-1292, 2009.
  7. Poole, J.A., T. A. Wyatt, M. E. Elliott, P.J. Oldenburg, J. H. Sisson, W.W. West, and D. J. Romberger. Organic dust exposure-induced adaptation response marked by persistent lung inflammation and pathology. Am J. Physiol. 296:L1085-95, 2009.
  8. Roy, L., C. A. McDonald, C. Jiang, A. J. Zeleznik, T. A. Wyatt, X. Hou, J. S. Davis. Convergence of cAMP/PKA and GSK3β/β-catenin signaling in progesterone synthesis. Endocrinology, 150:5036-5045, 2009.
  9. Bailey, K. L., J. H. Sisson, D. J. Romberger, J. E. Robinson, and T. A. Wyatt. Alcohol upregulates TLR2 through a NO/cGMP dependent pathway. Alcoholism Clin Exp Res, 34:51-56, 2010.
  10. Wyatt, T. A., R. E. Slager, A. J. Heires, J. M. DeVasure, S. G. VonEssen, and D. J. Romberger. Sequential activation of protein kinase C isoforms by swine confinement dust is mediated by tumor necrosis factor alpha. Am J Respir Cell and Mol. Biol. 42:706-715, 2010.
  11. Oldenburg P. J., T. A. Wyatt, and J. H. Sisson. Ethanol attenuates contraction of primary cultured rat airway smooth muscle cells. Am. J. Respir. Mol. Cell Biol. 43:539-545, 2010.
  12. Simet, S., J. H. Sisson, J. Pavlik, J. DeVasure, C. Boyer, X. Liu, S. Kawasaki, S. I. Rennard, and T. A. Wyatt. Long-term cigarette smoke exposure in a mouse model of ciliated epithelial cell function. Am J Respir Cell and Mol. Biol. 43:635-640, 2010.
  13. Arvisais, E., X. Hou, T. A. Wyatt, K. Shirasuna, H. Bollwein, A. Miyamoto, T. Hansen, B. R. Rueda, J. S. Davis. PGF2α represses IGF1 stimulated IRS1/PI3K/AKT signaling in the corpus luteum: role of Erk and p70S6K1. Mol. Endocrine. 24: 632-643, 2010.
  14. McCaskill, M. L., K. K. Kharbanda, D. J. Tuma, J. Reynolds, J. DeVasure, J. H. Sisson, and T. A. Wyatt. Hybrid malondialdehyde and acetaldehyde protein adducts form in the lungs of mice exposed to alcohol and cigarette smoke. Alcoholism: Clin Exp Res. 35(6):1106-13, 2011.
  15. Bailey, K. L., J. E. Robinson, J. H. Sisson, and T. A. Wyatt. Alcohol decreases RhoA activity through a Nitric Oxide (NO)/Cyclic GMP (cGMP)/ Protein Kinase G (PKG) dependent pathway in the airway epithelium. Alcoholism: Clin Exp Res. 35(7):1277-81, 2011.
  16. Poole, J. A., T. A. Wyatt, T. Kielian, P. Oldenburg, A. M. Gleason, A. Bauer, G. Golden, W. W. West, J. H Sisson, and D. J. Romberger. Toll-like receptor 2 (TLR2) Regulates Organic Dust-Induced Airway Inflammation. Am. J. Respir. Mol. Cell Biol. 45(4)711-9, 2011.
  17. Allen-Gipson, D. S., M. R. Blackburn, D. J. Schneider, H. Zhang, D. L. Bluitt, J. C. Jarrell, D. Yanov, J. H. Sisson, and T. A. Wyatt. Adenosine Activation of A2B Receptor(s) is Essential for Potentiating of Epithelial Ciliary Motility and Clearance. Am. J. Physiol. 301(2):L171-80, 2011.
  18. Poole, J. A., T. Kielian, T. A. Wyatt, A. M. Gleason, J. Stone, K. Palm, W. W. West, and D. J. Romberger. Organic Dust Augments Nucleotide-Binding Oligomerization Domain (NOD2) Expression via an NF-κB Pathway to Negatively Regulate Inflammatory Responses. Am. J. Physiology 301(3):L296-306, 2011.
  19. Fiedler, S. E., J. H. Sisson, T. A. Wyatt, J. A. Pavlik, T. M. Gambling, J. L. Carson, Daniel W. Carr. Loss of ASP but not ROPN1 Reduces Mammalian Ciliary Motility. Cell Motility Cytoskeleton 69(1): 22-32, 2012.
  20. Sironen, A., N. Kotaja, H. Mulhern, T. A. Wyatt, J. H. Sisson, J. A. Pavlik, M. Miiluniemi, M. D. Fleming, and L. Lee. Loss of Spef2 function in mice results in spermatogenesis defects and primary ciliary dyskinesia. Biol. of Reproduction 85(4):690-701, 2011.
  21. Simet, S. M., T. A. Wyatt, J. DeVasure, D. Yanov, and J. H. Sisson. Alcohol increases the permeability of tight junctions inBeas-2B and NHBE cells. Alcoholism: Clin Exp Res, 36(3):432-42, 2012.
  22. Wyatt, T. A., K. K. Kharbanda, M. L. McCaskill, D. J. Tuma, D. Yanov, J. DeVasure, and J. H. Sisson. Malondialdehyde-accetaldehyde (MAA) adducted protein inhalation causes lung injury. Alcohol 46:51-59, 2012.
  23. Navarrette, C.R., J. Hanes, E. Nance, J. H. Sisson and T. A. Wyatt. Particulate Matter in Cigarette Smoke Increases Ciliary Axoneme Beating through Mechanical Stimulation. J. Aerosol. Med. Pulm. Drug Deliv. 2012 (PMID: 22280523).
  24. Wyatt, T. A., J. H. Sisson, D. S. Allen-Gipson, M. L. McCaskill and J. A. Poole. Airway Epithelial Exposure to Cigarette Smoke and Alcohol Decreases Cilia Beating in a PKC-e Dependent Manner. Am. J. Pathol. (In Press).