Rheumatology and Immunology

Lynell W. Klassen, M.D.

Academic Office:Lynell Klassen, M.D.
MSB 5511
985511 Nebraska Medical Center
Omaha, NE  68198-5511

Practice Locations:
University of Nebraska Medical Center
Omaha VA Medical Center

Education:
1967    Tabor College, Hillsboro, Kansas
1968    University of Kansas, Lawrence
1969    B.A. Tabor College
1973    M.D. University of Kansas School of Medicine, Kansas City
1974    Intern, Internal Medicine, Department of Medicine,  University of Iowa Hospitals and Clinics, Iowa City
1975    Resident, Internal Medicine, Department of Medicine, University of Iowa Hospitals and Clinics
1977    Clinical and Research Associate, Arthritis and Rheumatism Branch, NIAMDD, National Institutes of 
            Health, Bethesda, MD
1978    Chief Resident, Department of Medicine, University of  Iowa Hospitals and Clinics

Current Hospital and Academic Appointments:
Henry J. Lehnhoff Professor and Chair, Department of Internal Medicine, UNMC   
 
Biographical Sketch:
Henry J. Lehnhoff Professor of Medicine and Chairman of the Department of Internal Medicine at the University of Nebraska Medical Center (UNMC) since 2005, Dr. Klassen received his M.D. from the University of Kansas School of Medicine and completed his residency at the University of Iowa Hospitals and Clinics.  Following a fellowship at the Arthritis and Rheumatism Branch of the National Institutes of Health, Dr. Klassen returned to the University of Iowa as chief resident, fellow-associate and assistant professor.  He came to UNMC in 1982 and has served as chief of the Division of Rheumatology and Immunology, VA chief of Rheumatology, vice-chair of Medicine and VA Associate Chief of Staff/Research.  At UNMC, he initiated the Experimental Immunology Laboratory, co-directed the Bone Marrow Transplant Program, and founded the HIV Clinic. Dr. Klassen has a long-standing interest in understanding the mechanisms of autoimmune disease. He has been continuously funded, from 1976, by the NIH and/or the VA to perform basic and translational research on cellular and molecular immunology.  He has been the recipient of a ten-year NIH Method to External Research In Time (M.E.R.I.T.) grant awarded for innovative research in the pathophysiology of autoimmune reactions and serves on the NIH NIAAA National Advisory Council.  He has been involved with multiple national educational programs for the American College of Rheumatology and the American College of Physicians and is currently director of the ACP Midwest Internal Medicine Board Review Course.

Research Interests/Current Research:
Pathogenesis of autoimmunity

Selected Publications/Current Publications:
1. Schaffert CS, Duryee MJ, DeVeney Al, Tuma, DJ, Thiele GM and Klassen, LW.  Ethanol Enhances the
    Fibrogenic Response in Precision Cut Liver Slices.  Am. J. Physiology GI&P (In press); 2010.
2. Thiele GM, Duryee MJ, Willis MS, Tuma DJ, Radio SJ, Hunter CD, Schaffert CS and Klassen LW. 
    Autoimmune Hepatitis Induced by Syngeneic Liver Cytosolic Proteins Biotransformed by Alcohol Metabolites.  
    Alcoholism: Clinical and Experimental Research (In press); 2010.
3. Schaffert CS, Duryee MJ, DeVeney Al, Tuma, DJ, Thiele GM and Klassen, LW.  Ethanol Enhances the
    Fibrogenic Response in Precision Cut Liver Slices.  Am. J. Physiol Gastrointest Liver Physiol.  299(3):G661-
    668: 2010
4. Duryee MJ, Anderson DR, Schaffert CS, Tuma DJ, Garvin RP, Klassen LW and Thiele GM. 
    Malondialdehyde/Acetaldehyde Adduct (MAA) is the Dominant Epitope Formed Following the Modification of 
    Proteins with MDA in Atherosclerosis. Free Radical Biology (In Press); 2010
5. Thiele GM, Duryee MJ, Willis MS, Tuma DJ, Radio SJ, Hunter CD, Schaffert CS and Klassen LW. 
    Autoimmune Hepatitis Induced by Syngeneic Liver Cytosolic Proteins Biotransformed by Alcohol Metabolites.
    Alcoholism: Clinical and Experimental Research (In press); 2010.

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