Rheumatology and Immunology

Ted Mikuls, M.D.

Ted Mikuls, M.D. Associate Professor, Internal Medicine
Division of Rheumatology

Academic Office:
University of Nebraska Medical Center 
986270 Nebraska Medical Center 
Omaha, NE 68198-6270

Practice Locations:
University of Nebraska Medical Center
Omaha VA Medical Center

Education:
1990    B .S., Ccum laude,  Santa Clara University, Santa Clara, CA
1995    M.D., High honors,  University of Nebraska Medical Center (UNMC), Omaha, NE
1998    Resident, Internal Medicine UNMC, Omaha, NE
1999    Chief Resident, Internal Medicine UNMC, Omaha, NE
2001    M.S.P.H., Epidemiology,  University of Alabama at Birmingham, Birmingham, AL
2001    Fellow in Rheumatology University of Alabama at Birmingham, Birmingham, AL
2002    Participant, NIH (K-30) Clinical University of Alabama at Research Training Program Birmingham,
            Birmingham, AL 

Current Hospital and Academic Appointments:
Associate Member, Eppley Institute, Cancer Prevention and Control Program
Faculty, University of Nebraska Graduate College
Director / Investigator, Nebraska Arthritis Outcomes Research Center (NAORC)
Director, Omaha VA RA/DMARD Clinic
Associate Professor, UNMC and Omaha VAMC, Omaha, NE
 
Biographical Sketch:
Dr. Mikuls currently serves on the U.S. FDA Arthritis Advisory Committee and chairs the American College of Rheumatology (ACR) Clinical Guidelines Subcommittee.   He has served on numerous other committees and national grant review study sections, including those for the VA, Arthritis Foundation, NIH, and the ACR.  He is co-director of the Nebraska Arthritis Outcomes Research Center.  Dr. Mikuls’ research efforts are focused on the epidemiology and health outcomes in rheumatoid arthritis (RA) and gout.  Ongoing projects involve the investigation of genetic and environmental determinants in RA disease expression in addition to exploring the role of complex gene-environment interactions in understudied populations (African Americans and male veterans).  He receives funding from the NIH, Veterans Affairs (VA), and the American College of Rheumatology REF Within Our Reach campaign. 

Research Interests/Current Research:
Outcomes and epidemiology of rheumatoid arthritis
Health outcomes and quality of care in gout

Selected Publications/Current Publications (selected from more than 80):
1. Mikuls TR, Fay BT, Michaud K, Sayles H, Thiele GM, Caplan L, Johnson D, Richards JS, Kerr GS, Cannon 
    GW, Reimold A.  Mortality in U.S. veteran men with rheumatoid arthritis: results from the VARA Registry.  
    Rheumatology (Oxford) 2011; 50: 101-9.0 [Epub ahead of print].
2. Mikuls TR, Sayles H, Yu F, LeVan T, Gould KA, Thiele GM, Conn D, Jonas BL, Callahan LF, Smith E, 
    Brasington R, Moreland LW, Reynolds R, Bridges SL Jr. Associations of cigarette smoking with rheumatoid 
    arthritis in African Americans.  Arthritis Rheum 2010; 62: 3560-8.
3. Curtis JR, Jain A, Askling J, Bridges SL, Carmona L, Dixon W, Finckh A, Hyrich K, Greenberg J, Kremer J, 
    Listing J, Michaud K, Mikuls T, Shadick N, Solomon DH, Wolfe F, Zink A.  A comparison of patient
    characteristics and outcomes in selected European and US rheumatoid arthritis registries. Semin Arthritis
    Rheum 2010; 40:2-14.e1. 
4. Mikuls TR, Sayles H, Yu F, LeVan T, Gould KA, Thiele GM, Conn D, Jonas BL, Callahan LF, Smith E,
    Brasington R, Moreland LW, Reynolds R, Bridges SL Jr. Associations of cigarette smoking with rheumatoid 
    arthritis in African Americans.  Arthritis Rheum 2010 [Epub ahead of print].
5. Quan LD, Purdue PE, Liu XM, Boska MD, Lele SM, Thiele GM, Mikuls TR, Dou H, Goldring SR, Wang D.
    Development of a macromolecular prodrug for the treatment of inflammatory arthritis: mechanisms involved in
    arthrotropism and sustained therapeutic efficacy.  Arthritis Res Ther 2010: R170 [Epub ahead of print].
6. Mikuls TR, Gould KA, Bynote KK, Yu F, LeVan TD, Thiele GM, Michaud KD, O’Dell JR, Reimold AM,
    Hooker R, Caplan L, Johnson DS, Kerr G, Richards JS, Cannon GW, Criswell LA, Noble JA, Bridges SL Jr, 
    Hughes L, Gregersen PK. Anti-citrullinated protein antibody (ACPA) in rheumatoid arthritis: influence of an 
    interaction between HLA-DRB1 shared epitope and a deletion polymorphism in glutathione s-transferase in a
    cross-sectional study.  Arthritis Res Ther 2010;12: R213 [Epub ahead of print].
7. Miriovsky BJ, Michaud K, Thiele GM, O’Dell JR, Cannon GW, Kerr G, Richards JS, Johnson D, Caplan L,
    Reimold A, Hooker R, Mikuls TR.  Anti-CCP antibody and rheumatoid factor concentrations predict greater
    disease activity in men with rheumatoid arthritis.  Ann Rheum Dis 2010; 69: 1292-7.
8. Mikuls TR, Payne JB, Reinhardt RA, Thiele GM, Maziarz E, Cannella AC, Holers VM, Kuhn KA, O’Dell JR. 
    Antibody responses to Porphyromonas gingivalis (P. gingivalis), in subjects with rheumatoid arthritis and 
    periodontitis. Int Immunopharmacol 2009; 9: 38-42.

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