Bhavana J. Dave, PhD, FACMG

Bhavana DaveBhavana J. Dave, PhD, FACMG
Human Genetics Laboratory
Munroe-Meyer Institute
985440 Nebraska Medical Center
Omaha, NE 68198-5440

Phone: (402) 559-9914
E-mail: bdave@unmc.edu


Professional Summary:

Bhavana Dave, Ph.D., FACMG, is Professor and Associate Director of the Human Genetics Laboratories at the University of Nebraska Medical Center, Munroe-Meyer Institute. Dr Dave is board certified in Clinical Cytogenetics by the American Board of Medical Genetics and she is a Fellow of American College of Medical Genetics. Dr Dave has been involved in patient care by providing clinical cytogenetic services utilizing cutting edge diagnostic tests including fluorescence in situ hybridization (FISH) and array based comparative genomic hybridization (aCGH). Dr Dave serves as a reviewer and is on the editorial board of Medical Genetics and Cancer Biology related journals.

Dr Dave’s research involves in-depth genetic characterization of lymphomas and leukemias and delineating the basic mechanisms of the genetic abnormalities that allows us to better comprehend the consequences of genetic changes and eventually leads to better disease management. Dr Dave is actively involved in translational research which expands our understanding of genetic diagnosis impacting the prognosis and management of a variety of diseases including cancer, developmental and prenatal disorders.

Education:

FACMG, Fellow of American College of Medical Genetics (Clinical Cytogenetics)
PhD, Maharaja Sayajirao Gujarat University, Baroda, Gujarat, India
BS, MS, Gujarat University, Ahmedabad, India

Courses Taught:

UNMC, PEDS 911 - Human Genetics and Cytogenetics Principles
UNMC, PEDS 912 - Human Cytogenetics Laboratory
Human Cytogenetics – Lectures and Case Reviews in Elective Rotations for Pathology, Pediatrics, and Internal Medicine Residents

Research Interests and Projects:

  • Chromosome 1p36 in angiogenesis and progression of Non Hodgkin Lymphoma
  • Role of TP73 in non Hodgkin Lymphoma progression
  • Lymphoma Defined Cytogenetically for Epidemiologic Study
  • Molecular Signatures to Improve Diagnosis and Outcome Prediction in NHL
  • Genetic Abnormalities in Follicular and Transformed Follicular Lymphoma
  • Genetic Pathways in the Evolution of Follicular Lymphoma
  • Epigenetic effects of Biotin on activation of endogenous retroviral sequences
  • Defining molecular subtypes of lymphoma for relevance to survival, etiology, and diagnosis
  • Case Control study of Pesticides and t(14;18) Lymphoma
  • Molecular Genetics of NHL: add(1)(p36) and add(14)(q32)
  • Genetics of Pediatric Hodgkin’s Disease
  • GENUS™ for automated karyotyping of multiple animal and plant species

Selected Publications: (within the last 5 years)

  • Chang CM, Wang SS, Dave BJ, Jain S, Vasef MA, Weisenburger DD, Cozen W, Davis S, Severson RL, Lynch CF, Rothman N, Cerhan JR, Hartge P, Morton LM. Risk factors for non-Hodgkin lymphoma subtypes defined by histology and t(14;18) in a population-based  case control study. Int J Cancer Oct 2010 Epub ahead of print PMID 20949561.
  • Eudy JE, Pickering DL, Lutz R, Platt K, Olney AH, Dave BJ, Sanger WG. Familial 18q22.3→18q23 Deletion Syndrome. Am J Med Genet A. 2010;152A(4):1046-1048.
  • Nelson M, Perkins SL, Dave BJ, Coccia PF, Bridge JA, Lyden ER, Heerema NA, Lones MA, Cairo MS and Sanger WG. An increased frequency of 13q deletions detected by fluorescence in situ hybridization and its impact on survival in children and adolescents with Burkitt lymphoma: results from the Children’s Cancer Group study CCG-5961. British J Hematol 2010;148(4):600-610.
  • Dave BJ, Olney AH, Zaleski DH, Pickering DL, Becker TA, Chipman H, Sanger WG. Inherited 14q Duplication and 21q Deletion: A Rare Adjacent-2 Segregation in Multiple Family Members. American J Med Genet A 2009;149A(10):2248-2253.
  • Gu K, Fu K, Jain S, Liu Z, Iqbal J, Li M, Sanger WG, Weisenburger DD, Greiner TC, Aoun P, Dave BJ and Chan WC. t(14;18)-negative Follicular Lymphomas Are Associated with a High Frequency of BCL6 Rearrangement at the Alternative Breakpoint Region. Mod Pathol 2009;22(9):1251-1257.

Professional Affiliations:

  • American Association for Cancer Research
  • American Society of Human Genetics
  • American College of Medical Genetics
  • Association of Genetic Technologists
  • Indian Association for Cancer Research
  • Indian Society of Cell Biology

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