TEST NAME: Methylation Analysis (of chromosomes 14 and 15)
INDICATIONS FOR TESTING:
TEST INFORMATION: Human genes are inactivated by methylation of cytosine to 5-methylcytosine. In typically developing individuals, genomic imprinting or differential methylation of alleles due to the parent of origin results in expression or suppression of parental alleles in a characteristic pattern at critical chromosomal regions. Our laboratory utilizes a methylation-specific PCR assay to identify methylation abnormalities of chromosome 14 and 15.
REQUIRED FORMS: Postnatal Test Request Form
OTHER FORMS: Request for Pre-Authorization for Genetic Testing (Postnatal Diagnoses on peripheral blood)
- Blood >3 mo of age: 3-5 ml in an EDTA tube (purple top)
- Blood (newborn minimum requirement): 1 ml in an EDTA tube (purple top)
- Extracted DNA: 5 μg
- Methylation Analysis of chromosome 14: 81402
- Methylation Analysis of chromosome 15: 81331
PRICING: Contact the laboratory billing staff for current costs
TURN-AROUND-TIMES: Results are typically available in 1-2 weeks; 5-7 days for newborn studies.