Pregnancy Loss Microarray

TEST NAME:   Pregnancy Loss Microarray
Also known as:   POC Array


  • Pregnancy loss at any gestational age

TEST INFORMATION:   This test is performed using an ISCA 180K platform including 120,000 oligonucleotides and 60,000 SNPs.


  • Evaluates hundreds of different genetic conditions, including aneuploidy, with one test
  • Detects large and small deletions and duplications, many of which are undetectable by traditional chromosome analysis
  • Significantly reduces the test failure rate seen with traditional cytogenetic methods because no cell culture is needed
  • Helps to rule out maternal cell contamination


  • Cannot identify all genetic conditions or the cause of all birth defects or pregnancy losses
  • Does not detect changes in the DNA sequence of genes
  • Cannot detect balanced chromosome rearrangements (less likely the cause of a pregnancy loss)
  • Unable to reliably detect all cases of mosaicism


  • A normal result indicates no clinically-significant chromosome anomalies were identified.
  • An abnormal or pathogenic result indicates that a chromosome anomaly was identified that likely provides an explanation for the pregnancy loss.
  • In some cases, the clinical significance of an identified chromosomal anomaly may not be well understood in the context of a pregnancy loss. These anomalies will be reported as variants of uncertain clinical significance.
  • Parental testing may be recommended in order to clarify whether the result is de novo or familial for the purpose of recurrence risk calculation.
  • In some circumstances, a result will be unavailable. These cases include testing on samples without sufficient fetal DNA or when maternal cell contamination cannot be ruled out.


  • In addition to fetal tissue, a maternal blood sample (paternal if a patient's pregnancy was the result of egg donation) is requested to rule out maternal cell contamination, which ensures that the microarray results are representative of the fetus rather than the mother.
  • Pregnancy Loss Microarray does NOT analyze the mother’s chromosomes. If desired, Postnatal Chromosome Analysis on maternal (or paternal) blood must be ordered separately.

REQUIRED FORMS:   Prenatal and Pregnancy Loss Test Request Form

OTHER FORMS:   Request for Pre-Authorization for Genetic Testing (Pregnancy Loss)

Comprehensive results are best achieved when maternal blood (paternal if a patient's pregnancy was the result of egg donation) is analyzed in addition to POC tissue.

  • Fetal tissue: 1 cm3 fetal tissue in tissue culture media or phosphate buffered saline or FFPE block
    • Preferred fetal tissue sample sites include buttocks or thigh. If fetal tissue is not available placental villi can be utilized. Separate villi from maternal blood and deciduas to reduce the chance for maternal cell contamination. Maintain and ship at room temperature.
  • Maternal blood (to rule out maternal cell contamination): 2 ml whole blood in sodium heparin tube (green top)
    • Draw paternal blood when the pregnancy is the result of egg donation.
  • Tissue, paraffin embedded: 3 curls of 25-30 microns thick of confirmed fetal tissue



  • Tissue (Fetal / Placental): 81229, 88233
  • Paraffin / FFPE: 81229

PRICING:   Contact the laboratory billing staff for current costs.

TURN-AROUND-TIME:   Results are typically available in 1 week on fresh fetal/placental tissue; 2 weeks on FFPE tissue.



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Phone:  402-559-5070 
1-800-656-3937 x95070
Fax:  402-559-7248